Reactome | Estrogen-responsive TFF1 gene expression

Estrogen-responsive TFF1 gene expression

Stable Identifier

R-HSA-9023859

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Estrogen-responsive TFF1 gene expression

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Estrogen-dependent TFF1 expression is promoted by the formation of FOXA1- and GATA3-dependent chromatin loops. (Laganière et al, 2005; Theodorou et al, 2013; reviewed in Zaret and Carroll, 2011).Interaction of ligand-bound ESR1 with the enhancer promotes recruitment of histone acetyltransferases and methyltransferases, which establish transcriptionally active chromatin structures and facilitate recruitment of RNA polymerase II (Métivier et al, 2003; reviewed in Xu et al, 2003, Arnal et al, 2017).

Literature References

PubMed ID	Title	Journal	Year
28539435	Membrane and Nuclear Estrogen Receptor Alpha Actions: From Tissue Specificity to Medical Implications Arnal, JF, Lenfant, F, Métivier, R, Flouriot, G, Henrion, D, Adlanmerini, M, Fontaine, C, Gourdy, P, Chambon, P, Katzenellenbogen, B, Katzenellenbogen, J	Physiol. Rev.	2017
16087863	From the Cover: Location analysis of estrogen receptor alpha target promoters reveals that FOXA1 defines a domain of the estrogen response Laganière, J, Deblois, G, Lefebvre, C, Bataille, AR, Robert, F, Giguère, V	Proc. Natl. Acad. Sci. U.S.A.	2005
22056668	Pioneer transcription factors: establishing competence for gene expression Zaret, KS, Carroll, JS	Genes Dev.	2011
23172872	GATA3 acts upstream of FOXA1 in mediating ESR1 binding by shaping enhancer accessibility Theodorou, V, Stark, R, Menon, S, Carroll, JS	Genome Res.	2013
14675539	Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter Métivier, R, Penot, G, Hübner, MR, Reid, G, Brand, H, Kos, M, Gannon, F	Cell	2003
14631847	Acetylation and methylation in nuclear receptor gene activation Xu, W, Cho, H, Evans, RM	Meth. Enzymol.	2003
16009131	Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1 Carroll, JS, Liu, XS, Brodsky, AS, Li, W, Meyer, CA, Szary, AJ, Eeckhoute, J, Shao, W, Hestermann, EV, Geistlinger, TR, Fox, EA, Silver, PA, Brown, M	Cell	2005