Reactome | EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2

EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2

Stable Identifier

R-HSA-9024993

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Dimeric bifunctional epoxide hydrolase 2 (EPHX2 dimer, soluble epoxide hydrolase, sEH) hydrolyses 13(S),14(S)-epoxy-docosahexaenoic acid (13(S),14(S)-epoxy-DHA) to form 13(R),14(S)-dihydroxy-docosahexaenoic acid, aka maresin 2 (MaR2) (Deng et al. 2014). Like MaR1, MaR2 possesses anti-inflammatory and pro-resolving activities although it is not as potent as MaR1 (Deng et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
25036362	Maresin biosynthesis and identification of maresin 2, a new anti-inflammatory and pro-resolving mediator from human macrophages Wang, CW, Serhan, CN, Cheng, CY, Arnardottir, HH, Li, Y, Deng, B, Dalli, J	PLoS ONE	2014