EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K

Stable Identifier
R-HSA-9027275
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Phosphorylated GAB1 in a complex with EPOR binds the p85 subunit of phosphatidylinositol 4,5-bisphosphate 3-kinase (PI3K) (Lecoq-Lafon et al. 1999, Wickrema et al. 1999, Bouscary et al. 2003).

Literature References
PubMed ID Title Journal Year
10455108 Engagement of Gab1 and Gab2 in erythropoietin signaling

Wickrema, A, Uddin, S, Sharma, A, Chen, F, Alsayed, Y, Ahmad, S, Sawyer, ST, Krystal, G, Yi, T, Nishada, K, Hibi, M, Hirano, T, Platanias, LC

J Biol Chem 1999
10194437 Erythropoietin induces the tyrosine phosphorylation of GAB1 and its association with SHC, SHP2, SHIP, and phosphatidylinositol 3-kinase

Lecoq-Lafon, C, Verdier, F, Fichelson, S, Chr├ętien, S, Gisselbrecht, S, Lacombe, C, Mayeux, P

Blood 1999
12506011 Critical role for PI 3-kinase in the control of erythropoietin-induced erythroid progenitor proliferation

Bouscary, D, Pene, F, Claessens, YE, Muller, O, Chr├ętien, S, Fontenay-Roupie, M, Gisselbrecht, S, Mayeux, P, Lacombe, C

Blood 2003
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