EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K

Stable Identifier
R-HSA-9027280
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Phosphatidylinositol 4,5-bisphosphate 3-kinase (PI3K) can directly bind phosphotyrosine-479 in the cytosolic domain of EPOR (Kubota et al. 2001, Bouscary et al. 2003, and inferred from mouse homologs).
Literature References
PubMed ID Title Journal Year
12506011 Critical role for PI 3-kinase in the control of erythropoietin-induced erythroid progenitor proliferation

Claessens, YE, Mayeux, P, Fontenay-Roupie, M, Bouscary, D, Pene, F, Lacombe, C, Muller, O, Chrétien, S, Gisselbrecht, S

Blood 2003
11598010 Src transduces erythropoietin-induced differentiation signals through phosphatidylinositol 3-kinase

Kubota, Y, Kitanaka, A, Ishida, T, Kamano, H, Ohnishi, H, Waki, M, Tanaka, T, Okutani, Y

EMBO J. 2001
Participants
Input
Output
Participates
as an event of
Inferred From
Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2 binds Pi3k (Mus musculus)
Authored
May, B  (2017-10-29)
Reviewed
McGraw, KL  (2018-08-14)
Created
May, B  (2017-10-29)
Cite Us!