Reactome | p-Y-VAV1 [cytosol]

p-Y-VAV1 [cytosol]

Stable Identifier

R-HSA-9029087

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Proto-oncogene vav, VAV_HUMAN

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External Reference Information

External Reference

UniProt:P15498 VAV1

Gene Names

VAV1, VAV

Chain

chain:1-845

Reference Genes

BioGPS Gene:7409 VAV1

COSMIC (genes):VAV1 VAV1

CTD Gene:7409 VAV1

dbSNP Gene:7409 VAV1

ENSEMBL:ENSG00000141968 VAV1

HGNC:12657 VAV1

KEGG:hsa:7409 VAV1

Monarch:7409 VAV1

NCBI Gene:7409 VAV1

OMIM:164875 VAV1

UCSC:P15498 VAV1

Reference Transcript

Other Identifiers

11741047_a_at

11763606_a_at

16857490

1919_at

206219_PM_s_at

206219_s_at

34481_at

3818548

3818549

3818552

3818558

3818559

3818560

3818562

3818563

3818564

3818565

3818566

3818567

3818568

3818569

3818570

3818571

3818572

3818573

3818575

3818576

3818577

3818578

3818579

3818580

3818581

3818582

3818584

3818587

3818590

3818591

3818592

3818593

3818594

3818595

7409

8025076

A_14_P134945

A_23_P38959

GE60470

GO:0001784

GO:0002376

GO:0005085

GO:0005515

GO:0005737

GO:0005829

GO:0005886

GO:0005911

GO:0006909

GO:0006955

GO:0007165

GO:0007166

GO:0007186

GO:0007229

GO:0008361

GO:0016192

GO:0016477

GO:0030101

GO:0030154

GO:0030168

GO:0030217

GO:0030593

GO:0031295

GO:0035556

GO:0038095

GO:0038096

GO:0042110

GO:0042267

GO:0043087

GO:0045785

GO:0045954

GO:0046872

GO:0048010

GO:0048870

GO:0051056

GO:0071466

GO:0072593

GO:0098542

GO:0098772

GO:0140031

HMNXSV003050730

ILMN_1717334

PH_hs_0006359

RNA147774|p0878_imsncRNA690

TC19000119.hg

X16316_at

g7108366_3p_a_at

Participates

as a member of

SOS1,p-Y-VAV1 [cytosol] (Homo sapiens)

as a component of

GRB2-1:p-Y-VAV1 [cytosol] (Homo sapiens)

Other forms of this molecule

VAV1 [plasma membrane]

VAV1 [cytosol]

p-Y174-VAV1 [cytosol]

p-Y142,Y160,Y174-VAV1 [plasma membrane]

Modified Residues

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_005419.2, NP_001245136.1

OpenTargets

ENSG00000141968

ENSEMBL

ENSP00000472929, ENSP00000469450, ENST00000596764, ENST00000602142

HPA

ENSG00000141968-VAV1

ZINC - Substances

VAV_HUMAN

ZINC target

P15498

PRO

P15498

Pharos - Targets

P15498

ZINC - Predictions - Purchasable

VAV_HUMAN

HMDB Protein

HMDBP10969

PDB

2MC1, 2LCT, 3BJI, 3KY9, 6NEW, 2ROR, 2CRH, 6NF1, 6NFA

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P78314 3BP2			0.788	8
UniProt:Q13094 LCP2	2	p-Y113,128,145-LCP2 [cytosol] (R-HSA-202175) LCP2 [cytosol] (R-HSA-202306)	0.758	9
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.665	3
UniProt:P00519 ABL1	6	p-S456-ABL1 [nucleoplasm] (R-HSA-5686576) ABL1 [nucleoplasm] (R-HSA-5686579) p-Y226,Y393-ABL1 [cytosol] (R-HSA-8942610) ABL1 [cytosol] (R-HSA-375987) p-Y226,Y393-ABL1 [nucleoplasm] (R-HSA-8985251) p-Y393-ABL1 [cytosol] (R-HSA-9865161)	0.602	5
UniProt:Q8N720 ZNF655	1	ZNF655 [nucleoplasm] (R-HSA-2127575)	0.581	5
UniProt:P63000 RAC1	6	RAC1 [plasma membrane] (R-HSA-351141) RAC1 [cytosol] (R-HSA-442615) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076)	0.558	2
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:P62736 ACTA2	1	ACTA2 [cytosol] (R-HSA-445792)	0.527	2
UniProt:Q15517 CDSN	2	CDSN [cornified envelope] (R-HSA-8847707) CDSN [plasma membrane] (R-HSA-6814395)	0.527	2
UniProt:Q562R1 ACTBL			0.527	2
UniProt:Q8IW75 SPA12			0.527	2
UniProt:Q6P4A8 PLBD1	1	PLBD1 [cytosol] (R-HSA-1524034)	0.527	2
UniProt:Q8NEX9 SDR9C7	1	SDR9C7 [endoplasmic reticulum membrane] (R-HSA-4084690)	0.527	2
UniProt:Q69YQ0 CYTSA			0.527	2
UniProt:Q6UWP8 SBSN	1	SBSN [secretory granule lumen] (R-HSA-9839544)	0.527	2
UniProt:Q07666 KHDRBS1	3	p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm] (R-HSA-8848970) p-Y435,Y440,Y443-KHDRBS1 [cytosol] (R-HSA-8848995) KHDRBS1 [nucleoplasm] (R-HSA-8848941)	0.524	3
UniProt:P08487 PLCG1			0.471	4

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