Reactome | Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene

Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene

Stable Identifier

R-HSA-9029566

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene

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In transient transfection assays performed in human hepatoma HepG2 cells, NR1H3 (LXR alpha) was found to interact with the nuclear receptor corepressor (NCOR) and nuclear receptor coactivator 1 (NCOA1 or SRC1) to regulate the UGT1A3 gene promoter (Verreault M et al. 2006). In the unliganded state, LXR:RXR heterodimers are bound to DNA response elements in association with co-repressor complexes resulting in repression of target genes (Wagner BL et al. 2003). Ligand binding to LXR induces conformational changes leading to release of co-repressor complexes and recruitment of co-activator complexes and transcription of target genes.

Literature References

PubMed ID	Title	Journal	Year
16871576	The liver X-receptor alpha controls hepatic expression of the human bile acid-glucuronidating UGT1A3 enzyme in human cells and transgenic mice Kaeding, J, Verreault, M, Trottier, J, Caron, P, Staels, B, Tukey, RH, Bonzo, JA, Bélanger, J, Barbier, O, Senekeo-Effenberger, K	Hepatology	2006
22541735	Liver X receptor biology and pharmacology: new pathways, challenges and opportunities Jakobsson, T, Gustafsson, JA, Steffensen, KR, Treuter, E	Trends Pharmacol. Sci.	2012