NTRK2 phosphorylates FRS3

Stable Identifier
R-HSA-9032426
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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NTRK2 phosphorylates FRS3
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Activated NTRK2 (TRKB) receptor phosphorylates FRS3 (also known as FRS2beta or STN2). Downstream of NTRK1 (TRKA)-mediated recruitment and phosphorylation, phosphorylated FRS3 binds to GRB2, SHP2 (PTPN11) and CKS proteins (CKS1, also known as CKS1B, and CKS2). FRS3 binding to GRB2, PTPN11 and CKSs has not been examined in the context of NTRK2 signaling (Dixon et al. 2006).
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Output
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as an event of
Catalyst Activity

protein tyrosine kinase activity of BDNF,NTF4:p-5Y-NTRK2:FRS3 [plasma membrane]

Physical Entity
BDNF,NTF4:p-5Y-NTRK2:FRS3 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Inferred From
Ntrk2 phosphorylates FRS3 (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-01-05)
Reviewed
Castrén, E  (2018-02-13)
Antila, H  (2018-02-13)
Created
Orlic-Milacic, M  (2017-12-13)
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