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PEX13:PEX14 [peroxisomal membrane]
Stable Identifier
R-HSA-9033095
Type
Complex
Species
Homo sapiens
Compartment
peroxisomal membrane
Synonyms
Peroxisomal Docking Complex
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Protein ubiquitination (Homo sapiens)
E3 ubiquitin ligases ubiquitinate target proteins (Homo sapiens)
PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Homo sapiens)
PEX2:PEX10:PEX12:PEX5S,L:Ub:UBE2D1,2,3:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX5S,L:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX5S,L:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Homo sapiens)
PEX2:PEX10:PEX12:PEX5S,L:Ub:UBE2D1,2,3:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX5S,L:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
Protein localization (Homo sapiens)
Peroxisomal protein import (Homo sapiens)
Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Homo sapiens)
PEX5L:PEX7:Cargo:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Homo sapiens)
PEX5S,L:Cargo:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX5S,L:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol (Homo sapiens)
PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14:PEX1:PEX6:PEX26:ZFAND6 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX1:PEX6:PEX26:ZFAND6:Ub:PEX5S,L:PEX14:PEX13:PEX2:PEX10:PEX12 dissociates yielding cytosolic Ub:PEX5S,L and membrane PEX14:PEX13:PEX2:PEX10:PEX12 (Homo sapiens)
PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX1:PEX6:PEX26:ZFAND6 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Homo sapiens)
PEX2:PEX10:PEX12:PEX5L:Ub:UBE2D1,2,3:PEX7:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Homo sapiens)
PEX2:PEX10:PEX12:PEX5S,L:Ub:UBE2D1,2,3:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX5S,L:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX5S,L:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Homo sapiens)
PEX2:PEX10:PEX12:PEX5L:Ub:UBE2D1,2,3:PEX7:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Homo sapiens)
PEX2:PEX10:PEX12:PEX5S,L:Ub:UBE2D1,2,3:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX5S,L:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14:PEX1:PEX6:PEX26:ZFAND6 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX1:PEX6:PEX26:ZFAND6 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX5L:PEX7:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Homo sapiens)
PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX5L:PEX7:Cargo:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Homo sapiens)
PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX5S,L:Cargo:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
28765278
The peroxisomal matrix protein translocon is a large cavity-forming protein assembly into which PEX5 protein enters to release its cargo
Barros-Barbosa, A
,
Pedrosa, AG
,
Rodrigues, TA
,
Dias, AF
,
Azevedo, JE
,
Francisco, T
J. Biol. Chem.
2017
Participants
components
PEX13 [peroxisomal membrane]
(Homo sapiens)
PEX14 [peroxisomal membrane]
(Homo sapiens)
Participates
as a component of
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX5S,L:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
Inferred To
PEX13:PEX14 [peroxisomal membrane]
(Bos taurus)
PEX13:PEX14 [peroxisomal membrane]
(Caenorhabditis elegans)
PEX13:PEX14 [peroxisomal membrane]
(Canis familiaris)
PEX13:PEX14 [peroxisomal membrane]
(Dictyostelium discoideum)
PEX13:PEX14 [peroxisomal membrane]
(Drosophila melanogaster)
PEX13:PEX14 [peroxisomal membrane]
(Gallus gallus)
PEX13:PEX14 [peroxisomal membrane]
(Mus musculus)
PEX13:PEX14 [peroxisomal membrane]
(Rattus norvegicus)
PEX13:PEX14 [peroxisomal membrane]
(Saccharomyces cerevisiae)
PEX13:PEX14 [peroxisomal membrane]
(Schizosaccharomyces pombe)
PEX13:PEX14 [peroxisomal membrane]
(Sus scrofa)
PEX13:PEX14 [peroxisomal membrane]
(Xenopus tropicalis)
Cross References
ComplexPortal
CPX-10021
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