Reactome | FIS1 [cytosol]

FIS1 [cytosol]

Stable Identifier

R-HSA-9033099

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Mitochondrial fission 1 protein, FIS1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9Y3D6 FIS1

Gene Names

FIS1, TTC11, CGI-135

Chain

chain:1-152

Reference Genes

BioGPS Gene:51024 FIS1

COSMIC (genes):FIS1 FIS1

CTD Gene:51024 FIS1

dbSNP Gene:51024 FIS1

ENSEMBL:ENSG00000214253 FIS1

HGNC:21689 FIS1

KEGG Gene (Homo sapiens):51024 FIS1

Monarch:51024 FIS1

NCBI Gene:51024 FIS1

OMIM:609003 FIS1

UCSC:Q9Y3D6 FIS1

Reference Transcript

RefSeq:NM_016068.2 FIS1

Other Identifiers

0001230364

11723286_a_at

17060909

218034_at

3064592

3064593

3064594

3064595

3064596

3064597

3064598

3064601

3064605

3064606

3064607

51024

65961_at

8141717

GE58669

GO:0000266

GO:0000422

GO:0001836

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005739

GO:0005741

GO:0005777

GO:0005778

GO:0005779

GO:0005783

GO:0005829

GO:0006605

GO:0006626

GO:0006810

GO:0006914

GO:0006915

GO:0006950

GO:0007005

GO:0007165

GO:0007204

GO:0008053

GO:0008150

GO:0008219

GO:0009056

GO:0010821

GO:0014850

GO:0015031

GO:0016020

GO:0016021

GO:0016559

GO:0031307

GO:0031667

GO:0032471

GO:0032991

GO:0035584

GO:0042592

GO:0042802

GO:0043226

GO:0043280

GO:0043525

GO:0043653

GO:0044877

GO:0045046

GO:0048856

GO:0051561

GO:0070584

GO:0071333

GO:0071396

GO:0090141

GO:0090314

GO:0097237

GO:1901653

GO:1902617

GO:1903579

GO:1904579

GO:1905395

GO:1990910

GO:2000192

GO:2001244

HMNXSV003037701

ILMN_1658351

PH_hs_0019795

g7705631_3p_s_at

Participates

as a member of

Class I Peroxisomal Membrane Proteins [cytosol] (Homo sapiens)

Other forms of this molecule

FIS1 [peroxisomal membrane]

Inferred To

fis1 [cytosol] (Danio rerio)

fis1 [cytosol] (Schizosaccharomyces pombe)

fis1 [cytosol] (Xenopus tropicalis)

FIS1 [cytosol] (Canis familiaris)

FIS1 [cytosol] (Dictyostelium discoideum)

FIS1 [cytosol] (Gallus gallus)

FIS1 [cytosol] (Saccharomyces cerevisiae)

FIS1 [cytosol] (Sus scrofa)

Fis1 [cytosol] (Drosophila melanogaster)

Fis1 [cytosol] (Mus musculus)

Fis1 [cytosol] (Rattus norvegicus)

fis-2 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_057152.2

OpenTargets

ENSG00000214253

HPA

ENSG00000214253-FIS1

GeneCards

Q9Y3D6

Ensembl

ENSP00000223136, ENST00000223136, ENSG00000214253

PRO

Q9Y3D6

Pharos - Targets

Q9Y3D6

Orphanet

24540

PDB

1PC2, 1NZN

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P51572 BCAP31	6	BCAP31(165-237) [endoplasmic reticulum membrane] (R-HSA-351909) BCAP31(2-245) [endoplasmic reticulum membrane] (R-HSA-201587) BCAP31(2-164) [endoplasmic reticulum membrane] (R-HSA-351826) BCAP31(238-246) [cytosol] (R-HSA-351912) BCAP31 [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985503) BCAP31 [endoplasmic reticulum membrane] (R-HSA-9714333)	0.599	8
UniProt:Q15125 EBP	1	EBP [endoplasmic reticulum membrane] (R-HSA-195697)	0.556	3
UniProt:Q3KNW5 SLC10A6	1	SLC10A6 [plasma membrane] (R-HSA-433091)	0.556	3
UniProt:Q8N4V1 MMGT1	1	MMGT1 [Golgi membrane] (R-HSA-5216137)	0.556	3
UniProt:O15552 FFAR2	1	FFAR2 [plasma membrane] (R-HSA-443944)	0.556	3
UniProt:O43889 CREB3	7	CREB3(1-256) [cytosol] (R-HSA-8874135) CREB3(1-256) [nucleoplasm] (R-HSA-8874190) CREB3(1-291) [Golgi membrane] (R-HSA-8874181) CREB3(257-291) [Golgi membrane] (R-HSA-8874207) CREB3 [Golgi membrane] (R-HSA-8874123) CREB3(292-395) [Golgi membrane] (R-HSA-8874173) CREB3 [endoplasmic reticulum membrane] (R-HSA-8874165)	0.553	2
UniProt:Q9HC29 NOD2	1	NOD2 [cytosol] (R-HSA-168411)	0.508	2
UniProt:Q14790 CASP8	8	CASP8(1-216) [cytosol] (R-HSA-933456) CASP8(375-384) [cytosol] (R-HSA-933460) CASP8(217-374) [mitochondrial outer membrane] (R-HSA-351869) CASP8(385-479) [mitochondrial outer membrane] (R-HSA-351828) CASP8(1-374) [cytosol] (R-HSA-3465404) CASP8(385-479) [cytosol] (R-HSA-76158) CASP8(217-374) [cytosol] (R-HSA-75975) CASP8(1-479) [cytosol] (R-HSA-57031)	0.499	2

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