Reactome | FIS1 [peroxisomal membrane]

FIS1 [peroxisomal membrane]

Stable Identifier

R-HSA-9033123

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

peroxisomal membrane

Synonyms

Mitochondrial fission 1 protein, FIS1_HUMAN

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
18782765	Targeting of hFis1 to peroxisomes is mediated by Pex19p Schrader, M, Delille, HK	J. Biol. Chem.	2008

External Reference Information

External Reference

UniProt:Q9Y3D6 FIS1

Gene Names

FIS1, TTC11, CGI-135

Chain

chain:1-152

Reference Genes

BioGPS Gene:51024 FIS1

COSMIC (genes):FIS1 FIS1

CTD Gene:51024 FIS1

dbSNP Gene:51024 FIS1

ENSEMBL:ENSG00000214253 FIS1

ENSEMBL_homo_sapiens_GENE:ENSG00000214253.9 FIS1

HGNC:21689 FIS1

KEGG Gene (Homo sapiens):51024 FIS1

Monarch:51024 FIS1

NCBI Gene:51024 FIS1

OMIM:609003 FIS1

UCSC:Q9Y3D6 FIS1

Reference Transcript

RefSeq:NM_016068.2 FIS1

Other Identifiers

11723286_a_at

17060909

218034_PM_at

218034_at

3064592

3064593

3064594

3064595

3064596

3064597

3064598

3064601

3064605

3064606

3064607

51024

65961_at

8141717

GE58669

GO:0000266

GO:0000422

GO:0001836

GO:0005515

GO:0005739

GO:0005741

GO:0005777

GO:0005778

GO:0005783

GO:0005829

GO:0006626

GO:0006886

GO:0006914

GO:0006915

GO:0007005

GO:0007031

GO:0007204

GO:0008053

GO:0008289

GO:0010821

GO:0012501

GO:0016020

GO:0016559

GO:0023052

GO:0032471

GO:0032991

GO:0035584

GO:0042802

GO:0043226

GO:0043280

GO:0043653

GO:0048856

GO:0051561

GO:0055065

GO:0055086

GO:0060090

GO:0070584

GO:0090141

GO:0090314

GO:1901135

GO:1903579

GO:2000192

GO:2001244

HMNXSV003037701

ILMN_1658351

PH_hs_0019795

g7705631_3p_s_at

Participates

as a member of

Class I Peroxisomal Membrane Proteins [peroxisomal membrane] (Homo sapiens)

Other forms of this molecule

FIS1 [cytosol]

Inferred To

fis1 [peroxisomal membrane] (Schizosaccharomyces pombe)

fis1 [peroxisomal membrane] (Xenopus tropicalis)

Fis1 [peroxisomal membrane] (Drosophila melanogaster)

Fis1 [peroxisomal membrane] (Mus musculus)

Fis1 [peroxisomal membrane] (Rattus norvegicus)

FIS1 [peroxisomal membrane] (Bos taurus)

FIS1 [peroxisomal membrane] (Canis familiaris)

FIS1 [peroxisomal membrane] (Dictyostelium discoideum)

FIS1 [peroxisomal membrane] (Gallus gallus)

FIS1 [peroxisomal membrane] (Saccharomyces cerevisiae)

FIS1 [peroxisomal membrane] (Sus scrofa)

fis-2 [peroxisomal membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_057152.2

OpenTargets

ENSG00000214253

GeneCards

Q9Y3D6

HPA

ENSG00000214253-FIS1

Ensembl

ENSP00000223136, ENST00000223136, ENSG00000214253

PRO

Q9Y3D6

Pharos - Targets

Q9Y3D6

Orphanet

24540

PDB

1NZN, 7YKA, 1PC2, 7YA9

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P51572 BCAP31	6	BCAP31 [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985503) BCAP31 [endoplasmic reticulum membrane] (R-HSA-9714333) BCAP31(2-245) [endoplasmic reticulum membrane] (R-HSA-201587) BCAP31(165-237) [endoplasmic reticulum membrane] (R-HSA-351909) BCAP31(2-164) [endoplasmic reticulum membrane] (R-HSA-351826) BCAP31(238-246) [cytosol] (R-HSA-351912)	0.599	8
UniProt:Q8N4V1 MMGT1	1	MMGT1 [Golgi membrane] (R-HSA-5216137)	0.556	3
UniProt:O15552 FFAR2	1	FFAR2 [plasma membrane] (R-HSA-443944)	0.556	3
UniProt:Q15125 EBP	1	EBP [endoplasmic reticulum membrane] (R-HSA-195697)	0.556	3
UniProt:Q3KNW5 SLC10A6	1	SLC10A6 [plasma membrane] (R-HSA-433091)	0.556	3
UniProt:O43889 CREB3	7	CREB3(1-256) [nucleoplasm] (R-HSA-8874190) CREB3(1-256) [cytosol] (R-HSA-8874135) CREB3(1-291) [Golgi membrane] (R-HSA-8874181) CREB3(257-291) [Golgi membrane] (R-HSA-8874207) CREB3 [Golgi membrane] (R-HSA-8874123) CREB3(292-371) [Golgi membrane] (R-HSA-8874173) CREB3 [endoplasmic reticulum membrane] (R-HSA-8874165)	0.553	2
UniProt:Q9HC29 NOD2	1	NOD2 [cytosol] (R-HSA-168411)	0.508	2
UniProt:Q14790 CASP8	8	CASP8(1-374) [cytosol] (R-HSA-3465404) CASP8(217-374) [mitochondrial outer membrane] (R-HSA-351869) CASP8(385-479) [mitochondrial outer membrane] (R-HSA-351828) CASP8(385-479) [cytosol] (R-HSA-76158) CASP8(375-384) [cytosol] (R-HSA-933460) CASP8(217-374) [cytosol] (R-HSA-75975) CASP8(1-216) [cytosol] (R-HSA-933456) CASP8(1-479) [cytosol] (R-HSA-57031)	0.499	2

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