NTRK2 and CDK5 promote activation of RAC1 by TIAM1

Stable Identifier
R-HSA-9033292
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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NTRK2 and CDK5 promote activation of RAC1 by TIAM1
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TIAM1, activated by binding to CDK5-phosphorylated and BDNF-activated NTRK2 (TRKB), promotes guanine nucleotide exchange on RAC1, which results in formation of the active RAC1:GTP complex (Lai et al. 2012).
Participants
Input
Output
Participates
as an event of
Catalyst Activity

guanyl-nucleotide exchange factor activity of BDNF:p-5Y,S479-NTRK2:p-Y829-TIAM1 [plasma membrane]

Physical Entity
BDNF:p-5Y,S479-NTRK2:p-Y829-TIAM1 [plasma membrane] (Homo sapiens)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
Inferred From
Ntrk2 and Cdk5 promote activation of Rac1 by Tiam1 (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-01-05)
Reviewed
Castrén, E  (2018-02-13)
Antila, H  (2018-02-13)
Created
Orlic-Milacic, M  (2017-12-20)
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