PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6

Stable Identifier
R-HSA-9033516
Type
Reaction [binding]
Species
Homo sapiens
Compartment
peroxisomal membrane
ReviewStatus
5/5
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PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6
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PEX1:PEX6:PEX26 (known as the Receptor Export Module) extracts ubiquitinated PEX5L from the peroxisomal membrane Docking and Translocation Module (Tamura et al. 2006, Tamura et al. 2014). PEX1 and PEX6 are soluble proteins that form a hexameric ring bound to PEX26 in the peroxisomal membrane (Matsumoto et al. 2003, Welle et al. 2005). ZFAND6 (AWP1) probably binds to ubiquitinated PEX5 and PEX6 and acts as an export factor (Miyata et al. 2012).
Literature References
PubMed ID Title Journal Year
12717447 The pathogenic peroxin Pex26p recruits the Pex1p-Pex6p AAA ATPase complexes to peroxisomes

Matsumoto, N, Tamura, S, Fujiki, Y

Nat. Cell Biol. 2003
15858711 Alternative splicing suggests extended function of PEX26 in peroxisome biogenesis

Obie, C, Morrell, J, Cajigas, I, Valle, D, Gould, SJ, Weller, S, Steel, G

Am. J. Hum. Genet. 2005
25016021 AAA peroxins and their recruiter Pex26p modulate the interactions of peroxins involved in peroxisomal protein import

Matsumoto, N, Takeba, R, Tamura, S, Fujiki, Y

J. Biol. Chem. 2014
21980954 AWP1/ZFAND6 functions in Pex5 export by interacting with cys-monoubiquitinated Pex5 and Pex6 AAA ATPase

Miyata, N, Noguchi, M, Mukai, S, Okumoto, K, Fujiki, Y

Traffic 2012
16854980 Dynamic and functional assembly of the AAA peroxins, Pex1p and Pex6p, and their membrane receptor Pex26p

Yasutake, S, Matsumoto, N, Tamura, S, Fujiki, Y

J. Biol. Chem. 2006
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Orthologous Events
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Bos taurus)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Gallus gallus)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Mus musculus)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Rattus norvegicus)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Sus scrofa)
Authored
May, B  (2017-12-20)
Reviewed
Van Veldhoven, PP  (2018-02-13)
Fransen, M  (2018-02-13)
Azevedo, JE  (2018-03-12)
Created
May, B  (2017-12-22)
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