Phosphorylation of STAT1 at Ser727

Stable Identifier
R-HSA-909552
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Kinases like Protein kinase C delta (PKC-delta) and Calcium/calmodulin-dependent protein kinase II (CaMK II ) can phosphorylate STAT1 at serine 727 (S727). This phosphorylation is not required for STAT1 homodimer formation, nuclear translocation and DNA binding. However, it is essential for the full transcriptional activation of STAT1.
Literature References
PubMed ID Title Journal Year
11972023 Requirement of Ca2+ and CaMKII for Stat1 Ser-727 phosphorylation in response to IFN-gamma

Nair, JS, Sun, W, Darnell JE, Jr, Zhang, JJ, DaFonseca, CJ, Tjernberg, A, Chait, BT

Proc Natl Acad Sci U S A 2002
15322115 Protein kinase Cdelta regulates apoptosis via activation of STAT1

Kalkofen, RL, DeVries, TA, Matassa, AA, Reyland, ME

J Biol Chem 2004
Participants
Participates
Catalyst Activity

protein kinase C activity of CaMKII and PKC-delta [cytosol]

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