Reactome | p-Y466,Y481-IFNAR1 [plasma membrane]

p-Y466,Y481-IFNAR1 [plasma membrane]

Stable Identifier

R-HSA-909675

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

p-IFNAR1, phospho IFNAR1, p-IFNAR1 (Y466, Y481)

Icon

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
      - RSV-host interactions (Homo sapiens)
        
        Evasion by RSV of host interferon responses (Homo sapiens)
        
        Recruitment of STAT2 to p-IFNAR1 (Homo sapiens)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Homo sapiens)
        
        p-IFNAR1:p-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y466,Y481-IFNAR1 [plasma membrane] (Homo sapiens)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:STAT2 [plasma membrane] (Homo sapiens)
        
        STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y466,Y481-IFNAR1 [plasma membrane] (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        SARS-CoV-2-host interactions (Homo sapiens)
        
        SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
        
        Phosphorylation of STAT1 (Homo sapiens)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2 [plasma membrane] (Homo sapiens)
        
        p-STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y466,Y481-IFNAR1 [plasma membrane] (Homo sapiens)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:p-STAT1 [plasma membrane] (Homo sapiens)
        
        p-STAT2:p-STAT1:p-IFNAR1:p-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y466,Y481-IFNAR1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P17181 IFNAR1

Gene Names

IFNAR1, IFNAR

Chain

signal peptide:1-27, chain:28-557

Reference Genes

BioGPS Gene:3454 IFNAR1

COSMIC (genes):IFNAR1 IFNAR1

CTD Gene:3454 IFNAR1

dbSNP Gene:3454 IFNAR1

ENSEMBL:ENSG00000142166 IFNAR1

HGNC:5432 IFNAR1

KEGG:hsa:3454 IFNAR1

Monarch:3454 IFNAR1

NCBI Gene:3454 IFNAR1

OMIM:107450 IFNAR1

UCSC:P17181 IFNAR1

Reference Transcript

Participates

as a component of

Other forms of this molecule

IFNAR1 [plasma membrane]

Inferred To

phospho-ifngr2.2 [plasma membrane] (Xenopus tropicalis)

phospho-il10rb [plasma membrane] (Xenopus tropicalis)

phospho-ifngr2 [plasma membrane] (Xenopus tropicalis)

phospho-p-Y466,Y481-IFNAR1 [plasma membrane] (Gallus gallus)

phospho-IFNAR1 [plasma membrane] (Bos taurus)

phospho-IFNAR1 [plasma membrane] (Canis familiaris)

phospho-IFNAR1 [plasma membrane] (Sus scrofa)

Homologues of p-Y466,Y481-IFNAR1 [plasma membrane] (Xenopus tropicalis)

phospho-Ifnar1 [plasma membrane] (Mus musculus)

phospho-Ifnar1 [plasma membrane] (Rattus norvegicus)

Modified Residues

Name

O4'-phospho-L-tyrosine at 466

Coordinate

466

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 481

Coordinate

481

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

Guide to Pharmacology - Targets

1723

ENSEMBL

ENST00000652450, ENSP00000514785, ENSP00000515348, ENST00000703556, ENST00000700080, ENST00000703515, ENSP00000515372, ENSP00000270139, ENSP00000498654, ENSG00000142166, ENST00000270139

OpenTargets

ENSG00000142166

GeneCards

IFNAR1

HPA

ENSG00000142166-IFNAR1

ZINC - Substances

INAR1_HUMAN

ZINC target

P17181

PRO

P17181

Pharos - Targets

P17181

ZINC - Predictions - Purchasable

INAR1_HUMAN

PDB

3S98, 3SE3, 4PO6, 3SE4

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P52630 STAT2	4	p-Y690-STAT2 [cytosol] (R-HSA-909683) STAT2 [cytosol] (R-HSA-882029) p-Y690-STAT2 [nucleoplasm] (R-HSA-909673) p-Y-STAT2 [cytosol] (R-HSA-8987235)	0.758	5
UniProt:P29597 TYK2	5	p-Y1054-TYK2 [cytosol] (R-HSA-1112598) p-Y1054,Y1055-TYK2 [cytosol] (R-HSA-909682) TYK2 [cytosol] (R-HSA-877348) p-Y-TYK2 [cytosol] (R-HSA-6784366) p-TYK2 [cytosol] (R-HSA-8950424)	0.564	2
UniProt:P42224 STAT1	8	STAT1 [cytosol] (R-HSA-629622) p-Y701-STAT1 [cytosol] (R-HSA-8951202) p-Y701-STAT1 [nucleoplasm] (R-HSA-8985905) p-Y701-STAT1 [cytosol] (R-HSA-3132766) p-Y701-STAT1 [nucleoplasm] (R-HSA-6788624) p-Y701,S727-STAT1 [cytosol] (R-HSA-9850842) p-STAT1 [cytosol] (R-HSA-8950418) p-STAT1 [nucleoplasm] (R-HSA-8987140)	0.499	2