Formation of p-STAT1 homodimer

Stable Identifier
R-HSA-909718
Type
Reaction
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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Formation of p-STAT1 homodimer
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Under certain conditions type I IFNs, IFNA/B are able to activate genes through a second STAT-based signaling cascade enabling the formation of p-STAT1:p-STAT1 homodimers called IFNA-activated-factor (AAF).

Literature References
PubMed ID Title Journal Year
7510216 Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions

Cowburn, D, Horvath, CM, Huang, LH, Darnell JE, Jr, Qureshi, SA, Shuai, K

Cell 1994
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2 [plasma membrane]

Physical Entity
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
Formation of p-STAT1 homodimer (Bos taurus)
Formation of p-STAT1 homodimer (Canis familiaris)
Formation of p-STAT1 homodimer (Danio rerio)
Formation of p-STAT1 homodimer (Gallus gallus)
Formation of p-STAT1 homodimer (Mus musculus)
Formation of p-STAT1 homodimer (Rattus norvegicus)
Formation of p-STAT1 homodimer (Xenopus tropicalis)
Authored
Garapati, P V  (2010-07-07)
Reviewed
Abdul-Sater, AA  (2010-08-17)
Schindler, C  (2010-08-17)
Created
Garapati, P V  (2010-07-07)
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