Translocation of ISGF3 complex to nucleus

Stable Identifier
R-HSA-909721
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
nuclear envelope
ReviewStatus
5/5
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Translocation of ISGF3 complex to nucleus
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The resultant ISGF3 trimeric complex then migrates to the nucleus and binds to interferon-stimulated response elements (ISREs). IRF9 is the DNA binding part of this ISGF3 complex. These ISREs are present in the promoters of a subset of ISGs (interferon stimulated genes), such as promyelocytic leukemia (PML), ISG15 ubiquitin-like modifier (ISG15), interferon-induced protein with tetratricopeptide repeats 2 (ISG54) and interferon alpha-inducible protein 6 (IFI6) to elicit an antiviral response.
Literature References
PubMed ID Title Journal Year
17351669 STAT activation and differential complex formation dictate selectivity of interferon responses

Szweykowska-Kulinska, Z, Wesoly, J, Bluyssen, HA

Acta Biochim Pol 2007
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Authored
Garapati, P V  (2010-07-07)
Reviewed
Abdul-Sater, AA  (2010-08-17)
Schindler, C  (2010-08-17)
Created
Garapati, P V  (2010-07-07)
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