The extracellular domain of IFNAR1 is atypical, consisting of a tandem array of four FNIII domains and the first three N-terminal FNIII domains are involved in ligand recognition. IFNAR1 is recruited to the binary complex (IFNA/B:IFNAR2) on the membrane to form the ternary complex (IFNAR2:IFNA/B:IFNAR1). TYK2 kinase is pre-associated with IFNAR1 and JAK1 with IFNAR2. The binding of IFNA/B to IFNA receptors brings these JAK kinase together, allowing cross-phosphorylation and kinase activation.
Jaitin, DA, Schreiber, G, Roisman, LC, Baker, DP
Sempé, P, Gallet, X, Nardeux, PC, Guymarho, J, Eid, P, Tovey, MG, Cajean-Feroldi, C, Escary, JL, Nosal, F, Baychelier, F
Pellegrini, S, Piehler, J, Schreiber, G, Uzé, G
Piehler, J, Gavutis, M, Lata, S, Lamken, P
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