STAT2 recruited to the IFNAR1 subunit then becomes tyrosine phosphorylated on residue 690 by TYK2 kinase. This phosphotyrosine provides a docking site for recruitment of STAT1 to IFNAR1, which is then tyrosine phosphorylated and activated.
Geiger, TR, Martin, JM
Fish, EN, Leaman, DW, Rani, MR, Ransohoff, RM, Croze, E, Wolfman, A, Leung, S, Han, Y
Horvath, CM, Stark, GR, Darnell JE, Jr, Kerr, IM, Improta, T, Schindler, C
protein tyrosine kinase activity of IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:STAT2 [plasma membrane]
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