Reactome | p(Y593)-IL3RB:Activated JAK2 [plasma membrane]

p(Y593)-IL3RB:Activated JAK2 [plasma membrane]

Stable Identifier

R-HSA-912306

Type

Complex

Species

Homo sapiens

Compartment

plasma membrane

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-2 family signaling (Homo sapiens)
      - Interleukin receptor SHC signaling (Homo sapiens)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Homo sapiens)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, activated JAK2, phosphorylated Bc [plasma membrane] (Homo sapiens)
        
        IL3RA:IL3:p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Homo sapiens)
        
        p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Homo sapiens)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, activated JAK2, phosphorylated Bc [plasma membrane] (Homo sapiens)
        
        IL3RA:IL3:p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Homo sapiens)
        
        p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Homo sapiens)
        
        Phosphorylated SHC1 recruits GRB2:GAB2 (Homo sapiens)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, activated JAK2, phosphorylated Bc [plasma membrane] (Homo sapiens)
        
        IL3RA:IL3:p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Homo sapiens)
        
        p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Homo sapiens)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Homo sapiens)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, activated JAK2, phosphorylated Bc [plasma membrane] (Homo sapiens)
        
        IL3RA:IL3:p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Homo sapiens)
        
        p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Homo sapiens)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, activated JAK2, phosphorylated Bc [plasma membrane] (Homo sapiens)
        
        IL3RA:IL3:p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Homo sapiens)
        
        p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Homo sapiens)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Homo sapiens)
      - Interleukin receptor SHC signaling (Homo sapiens)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Homo sapiens)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, activated JAK2, phosphorylated Bc [plasma membrane] (Homo sapiens)
        
        IL3RA:IL3:p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Homo sapiens)
        
        p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Homo sapiens)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, activated JAK2, phosphorylated Bc [plasma membrane] (Homo sapiens)
        
        IL3RA:IL3:p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Homo sapiens)
        
        p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Homo sapiens)
        
        Phosphorylated SHC1 recruits GRB2:GAB2 (Homo sapiens)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, activated JAK2, phosphorylated Bc [plasma membrane] (Homo sapiens)
        
        IL3RA:IL3:p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Homo sapiens)
        
        p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Homo sapiens)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Homo sapiens)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, activated JAK2, phosphorylated Bc [plasma membrane] (Homo sapiens)
        
        IL3RA:IL3:p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Homo sapiens)
        
        p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Homo sapiens)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, activated JAK2, phosphorylated Bc [plasma membrane] (Homo sapiens)
        
        IL3RA:IL3:p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Homo sapiens)
        
        p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Homo sapiens)

Participants

components

Participates

as a component of

IL3RA:IL3:p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Homo sapiens)

Inferred To

p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Bos taurus)

p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Canis familiaris)

p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Gallus gallus)

p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Mus musculus)

p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Rattus norvegicus)

Cite Us!