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SPO11:double stand break [nucleoplasm]
Stable Identifier
R-HSA-912365
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
SPO11 Covalently Attached to Double-strand Break
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Meiosis (Homo sapiens)
Meiotic recombination (Homo sapiens)
MRN:CtIP endonucleolytically cleaves single-strand DNA 3' to SPO11 (Homo sapiens)
SPO11:double stand break [nucleoplasm] (Homo sapiens)
SPO11 hydrolyzes DNA forming double-strand breaks (Homo sapiens)
SPO11:double stand break [nucleoplasm] (Homo sapiens)
Reproduction (Homo sapiens)
Meiosis (Homo sapiens)
Meiotic recombination (Homo sapiens)
MRN:CtIP endonucleolytically cleaves single-strand DNA 3' to SPO11 (Homo sapiens)
SPO11:double stand break [nucleoplasm] (Homo sapiens)
SPO11 hydrolyzes DNA forming double-strand breaks (Homo sapiens)
SPO11:double stand break [nucleoplasm] (Homo sapiens)
General
The gene encoding SPO11 shares sequence similarity to TopoVI, a type II topoisomerase. SPO11 dimers cleave both strands of DNA. Each subunit of the dimer remains covalently attached to the 5' end of one strand of DNA via a phosphodiester linkage to a conserved tyrosine residue of SPO11. In addition to SPO11, work from budding yeast has shown a total of 7 proteins essential for double strand break formation. The mammalian ortholog of Mei4 (S. cerevisiae) as well as a mammalian-specific gene called Mei1 are essential to formation of meiotic double strand breaks.
Participants
components
x 2
DNA double-strand break ends [nucleoplasm]
SPO11 Dimer [nucleoplasm]
(Homo sapiens)
Participates
as an input of
MRN:CtIP endonucleolytically cleaves single-strand DNA 3' to SPO11 (Homo sapiens)
as an output of
SPO11 hydrolyzes DNA forming double-strand breaks (Homo sapiens)
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