Reactome | MSH5 [nucleoplasm]

MSH5 [nucleoplasm]

Stable Identifier

R-HSA-912435

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

MutS protein homolog 5, MSH5_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O43196 MSH5

Gene Names

MSH5

Chain

chain:1-834

Reference Genes

BioGPS Gene:4439 O431964

COSMIC (genes):MSH5 MSH5

CTD Gene:4439 O431964

dbSNP Gene:4439 O431964

ENSEMBL:ENSG00000204410 MSH5

HGNC:7328 O431964

KEGG:hsa:4439 O431964

Monarch:4439 O431964

NCBI Gene:4439 O431964

OMIM:603382 O431964

UCSC:O43196 O431964

Reference Transcript

Participates

as an input of

Formation of meiotic holliday junction (Homo sapiens)

as an output of

Resolution of meiotic holliday junction (Homo sapiens)

as a component of

MSH4:MSH5 [nucleoplasm] (Homo sapiens)

Cross References

OpenTargets

ENSG00000204410

ENSEMBL

ENST00000375703, ENSP00000388037, ENSG00000235222, ENSP00000399721, ENSG00000230293, ENSP00000364855, ENSP00000394017, ENST00000441401, ENST00000448617, ENST00000435700, ENSP00000404892, ENST00000416549, ENST00000375750, ENSG00000227314, ENSP00000364892, ENSP00000402659, ENSG00000230961, ENSP00000407047, ENSG00000204410, ENSP00000387609, ENSP00000364908, ENSP00000409181, ENST00000375755, ENSP00000394649, ENSP00000396509, ENSP00000364903, ENST00000456839, ENST00000427735, ENST00000436091, ENST00000420731, ENST00000436192, ENST00000441395, ENST00000457742, ENSP00000406868, ENSP00000400187, ENST00000412070, ENSP00000406269, ENST00000419269, ENST00000375740

GeneCards

MSH5

HPA

ENSG00000204410-MSH5

PRO

O43196

Pharos - Targets

O43196

Orphanet

MSH5

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00519 ABL1	6	p-S456-ABL1 [nucleoplasm] (R-HSA-5686576) ABL1 [nucleoplasm] (R-HSA-5686579) p-Y226,Y393-ABL1 [cytosol] (R-HSA-8942610) p-Y226,Y393-ABL1 [nucleoplasm] (R-HSA-8985251) ABL1 [cytosol] (R-HSA-375987) p-Y393-ABL1 [cytosol] (R-HSA-9865161)	0.819	10
UniProt:O15457 MSH4	1	MSH4 [nucleoplasm] (R-HSA-912455)	0.635	5

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