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ATR [nucleoplasm]
Stable Identifier
R-HSA-912443
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Serine/threonine-protein kinase ATR, ATR_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
G2/M Checkpoints (Homo sapiens)
Activation of ATR in response to replication stress (Homo sapiens)
Activation of claspin (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
ATR:ATRIP [nucleoplasm] (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
Binding of ATR-ATRIP to the RPA-ssDNA complex (Homo sapiens)
ATR:ATRIP [nucleoplasm] (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
ATR:ATRIP:RPA:ssDNA signaling complex [nucleoplasm] (Homo sapiens)
ATR:ATRIP [nucleoplasm] (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
Recruitment and activation of Chk1 (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
ATR:ATRIP [nucleoplasm] (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
G2/M DNA damage checkpoint (Homo sapiens)
ATR phosphorylates TP53 (Homo sapiens)
ATR:ATRIP [nucleoplasm] (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP [nucleoplasm] (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
Recruitment and activation of Chk1 (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
ATR:ATRIP [nucleoplasm] (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
Meiosis (Homo sapiens)
Meiotic synapsis (Homo sapiens)
ATR Kinase is recruited to unsynapsed regions (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
Synaptonemal Complex:BRCA1:ATR [nucleoplasm] (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
ATR phosphorylates Histone H2A.X at unsynapsed regions (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
Synaptonemal Complex:BRCA1:ATR [nucleoplasm] (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to heat stress (Homo sapiens)
Regulation of HSF1-mediated heat shock response (Homo sapiens)
DBC1 is phosphorylated by ATM/ART (Homo sapiens)
ATM/ATR kinase [nucleoplasm] (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
Homology Directed Repair (Homo sapiens)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
HDR through Homologous Recombination (HRR) (Homo sapiens)
Homologous DNA Pairing and Strand Exchange (Homo sapiens)
Presynaptic phase of homologous DNA pairing and strand exchange (Homo sapiens)
RAD51 binds BRCA2 at resected DNA DSBs (Homo sapiens)
ATR:ATRIP [nucleoplasm] (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] (Homo sapiens)
ATR:ATRIP [nucleoplasm] (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
HDR through Single Strand Annealing (SSA) (Homo sapiens)
Association of RAD51 with RAD52:DNA double-strand break ends (Homo sapiens)
RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] (Homo sapiens)
ATR:ATRIP [nucleoplasm] (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] (Homo sapiens)
ATR:ATRIP [nucleoplasm] (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
Association of RAD52 with the RPA complex at resected DNA DSBs (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] (Homo sapiens)
ATR:ATRIP [nucleoplasm] (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] (Homo sapiens)
ATR:ATRIP [nucleoplasm] (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
ERCC1:XPF cleaves flaps generated by SSA (Homo sapiens)
ATR:ATRIP [nucleoplasm] (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] (Homo sapiens)
ATR:ATRIP [nucleoplasm] (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
RAD52 promotes single strand annealing at resected DNA DSBs (Homo sapiens)
RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] (Homo sapiens)
ATR:ATRIP [nucleoplasm] (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] (Homo sapiens)
ATR:ATRIP [nucleoplasm] (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
Processing of DNA double-strand break ends (Homo sapiens)
ATR activation at DNA DSBs (Homo sapiens)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP [nucleoplasm] (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP [nucleoplasm] (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
ATR phosphorylates RPA2 (Homo sapiens)
ATR:ATRIP [nucleoplasm] (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP [nucleoplasm] (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] (Homo sapiens)
ATR:ATRIP [nucleoplasm] (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
Activation of CHEK1 at resected DNA DSBs (Homo sapiens)
ATR:ATRIP [nucleoplasm] (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] (Homo sapiens)
ATR:ATRIP [nucleoplasm] (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] (Homo sapiens)
ATR:ATRIP [nucleoplasm] (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
Binding of ATR:ATRIP to RPA at resected DNA DSBs (Homo sapiens)
ATR:ATRIP [nucleoplasm] (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP [nucleoplasm] (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
CHEK1 is recruited to resected DNA DSBs (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] (Homo sapiens)
ATR:ATRIP [nucleoplasm] (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] (Homo sapiens)
ATR:ATRIP [nucleoplasm] (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
Fanconi Anemia Pathway (Homo sapiens)
ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
ATR:ATRIP [nucleoplasm] (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] (Homo sapiens)
ATR:ATRIP [nucleoplasm] (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
The complex of ATR and ATRIP is recruited to ICL-DNA (Homo sapiens)
ATR:ATRIP [nucleoplasm] (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] (Homo sapiens)
ATR:ATRIP [nucleoplasm] (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Diseases of DNA repair (Homo sapiens)
Diseases of DNA Double-Strand Break Repair (Homo sapiens)
Defective homologous recombination repair (HRR) due to BRCA2 loss of function (Homo sapiens)
Impaired BRCA2 binding to RAD51 (Homo sapiens)
BRCA2 mutants with BRC defects or a defect in the C-terminal RAD51 binding site do not bind RAD51 (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] (Homo sapiens)
ATR:ATRIP [nucleoplasm] (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
ATR phosphorylates TP53 (Homo sapiens)
ATR:ATRIP [nucleoplasm] (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP [nucleoplasm] (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
TP53 Regulates Transcription of DNA Repair Genes (Homo sapiens)
CDK12 stimulates expression of DNA repair genes (Homo sapiens)
BRCA1, ATR, FANCD2, FANCI, ATM, MDC1, CHEK1, RAD51D [nucleoplasm] (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
Reproduction (Homo sapiens)
Meiosis (Homo sapiens)
Meiotic synapsis (Homo sapiens)
ATR Kinase is recruited to unsynapsed regions (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
Synaptonemal Complex:BRCA1:ATR [nucleoplasm] (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
ATR phosphorylates Histone H2A.X at unsynapsed regions (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
Synaptonemal Complex:BRCA1:ATR [nucleoplasm] (Homo sapiens)
ATR [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13535 ATR
Gene Names
ATR, FRP1
Chain
chain:1-2644
Reference Genes
BioGPS Gene:545 ATR
COSMIC (genes):ATR ATR
CTD Gene:545 ATR
dbSNP Gene:545 ATR
ENSEMBL:ENSG00000175054 ATR
ENSEMBL:ENSG00000175054.16 ATR
HGNC:882 ATR
KEGG Gene (Homo sapiens):545 ATR
Monarch:545 ATR
NCBI Gene:545 ATR
OMIM:601215 ATR
UCSC:Q13535 ATR
Reference Transcript
RefSeq:NM_001184.3 ATR
RefSeq:XM_017006643.1 ATR
Other Identifiers
11743838_a_at
16959985
209902_PM_at
209902_at
209903_PM_s_at
209903_s_at
2698845
2698846
2698851
2698852
2698856
2698857
2698858
2698859
2698862
2698865
2698866
2698867
2698868
2698874
2698878
2698879
2698880
2698881
2698882
2698883
2698884
2698888
2698889
2698891
2698892
2698893
2698894
2698895
2698896
2698897
2698900
2698901
2698903
2698904
2698906
2698907
2698908
2698909
2698910
2698911
2698912
2698913
2698914
2698915
2698917
2698919
2698920
2698921
2698922
2698924
2698925
2698927
2698928
2698929
2698930
2698931
2698934
2698935
2698936
2698942
37229_at
545
8091190
A_23_P136058
A_33_P3362498
GE59204
GO:0000077
GO:0000166
GO:0000723
GO:0000781
GO:0003677
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005694
GO:0005794
GO:0006139
GO:0006260
GO:0006281
GO:0006468
GO:0006950
GO:0006974
GO:0008156
GO:0009410
GO:0016301
GO:0016310
GO:0016605
GO:0016740
GO:0018105
GO:0019219
GO:0023052
GO:0031297
GO:0032200
GO:0032212
GO:0032405
GO:0032407
GO:0034644
GO:0036211
GO:0036297
GO:0043226
GO:0043517
GO:0046685
GO:0046777
GO:0048584
GO:0051128
GO:0060255
GO:0065003
GO:0070198
GO:0070310
GO:0071480
GO:0080135
GO:0090399
GO:0097694
GO:0097695
GO:0106310
GO:0140096
GO:1900034
GO:1904884
GO:2000779
HMNXSV003021494
ILMN_1660342
ILMN_1810385
ILMN_2277201
ILMN_2376771
PH_hs_0004476
TC03001854.hg
U49844_at
g1235901_3p_a_at
Participates
as a member of
ATM/ATR kinase [nucleoplasm] (Homo sapiens)
BRCA1, ATR, FANCD2, FANCI, ATM, MDC1, CHEK1, RAD51D [nucleoplasm] (Homo sapiens)
as an input of
ATR Kinase is recruited to unsynapsed regions (Homo sapiens)
as a component of
Synaptonemal Complex:BRCA1:ATR [nucleoplasm] (Homo sapiens)
ATR:ATRIP [nucleoplasm] (Homo sapiens)
Inferred To
atr [nucleoplasm]
(Xenopus tropicalis)
mei-41 [nucleoplasm]
(Drosophila melanogaster)
Atr [nucleoplasm]
(Mus musculus)
Atr [nucleoplasm]
(Rattus norvegicus)
ATR [nucleoplasm]
(Bos taurus)
ATR [nucleoplasm]
(Canis familiaris)
ATR [nucleoplasm]
(Danio rerio)
ATR [nucleoplasm]
(Gallus gallus)
ATR [nucleoplasm]
(Sus scrofa)
atl-1 [nucleoplasm]
(Caenorhabditis elegans)
Cross References
RefSeq
XP_016862132.1
,
NP_001175.2
Guide to Pharmacology - Targets
1935
OpenTargets
ENSG00000175054
ZINC - Substances
ATR_HUMAN
ZINC - Biogenic
ATR_HUMAN
ZINC target
Q13535
PRO
Q13535
PDB
5YZ0
ZINC - Metabolites
ATR_HUMAN
HPA
ENSG00000175054-ATR
GeneCards
Q13535
Ensembl
ENSG00000175054
,
ENSP00000343741
,
ENSP00000499589
,
ENST00000350721
,
ENST00000661310
Pharos - Targets
Q13535
ZINC - Predictions - Purchasable
ATR_HUMAN
Orphanet
15333
HMDB Protein
HMDBP01308
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8WXE1 ATRIP
1
ATRIP [nucleoplasm]
(R-HSA-176231)
0.779
4
UniProt:Q9BW66 CINP
0.612
5
UniProt:Q9Y4R8 TELO2
0.597
4
UniProt:P50750 CDK9
1
CDK9 [nucleoplasm]
(R-HSA-51801)
0.558
3
UniProt:Q99459 CDC5L
1
CDC5L [nucleoplasm]
(R-HSA-5420887)
0.544
3
UniProt:P0DTC7 7a
5
7a [endolysosome membrane]
(R-COV-9755945)
7a [endoplasmic reticulum membrane]
(R-COV-9727308)
7a [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9694750)
7a [endocytic vesicle membrane]
(R-COV-9694645)
7a [virion membrane]
(R-COV-9694648)
0.527
2
UniProt:O43156 TTI1
0.499
2
UniProt:Q9Y6K9 IKBKG
12
IKBKG D406V [cytosol]
(R-HSA-5262943)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG *420Wext*447 [cytosol]
(R-HSA-5262978)
monoSUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG [nucleoplasm]
(R-HSA-4755413)
K63polyUb-IKBKG [cytosol]
(R-HSA-202530)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
IKBKG [cytosol]
(R-HSA-168108)
0.499
2
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