Formation of meiotic heteroduplex

Stable Identifier
Reaction [omitted]
Homo sapiens
Meiotic Strand Invasion
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The HOP2(TBPIP):MND1 complex stimulates RAD51 and DMC1 mediated strand exchange by an unknown mechanism. Following double strand break (DSB) formation and strand resection, RAD51 and DMC1 coat single-stranded 3' ends of DNA and catalyze the search for homology and strand invasion into the DNA duplex of the chromosomal homolog (Baumann et al. 1996, Barlow et al. 1997, Benson et al. 1998, Baumann and West 1999, Masson et al. 1999, Sehorn et al. 2004, Murayama et al. 2008). The invading strand displaces the original strand of the chromosomal homolog creating a D-loop structure. Other proteins present in the complex are inferred from cytology (Barlow et al. 1997, Oliver-Bonet et al. 2005, Oliver-Bonet et al. 2007).
Literature References
PubMed ID Title Journal Year
10438626 Heteroduplex formation by human Rad51 protein: effects of DNA end-structure, hRP-A and hRad52.

West, SC, Baumann, P

J Mol Biol 1999
15164066 Human meiotic recombinase Dmc1 promotes ATP-dependent homologous DNA strand exchange

Unger, VM, Bussen, W, Sigurdsson, S, Sehorn, MG, Sung, P

Nature 2004
10562567 The meiosis-specific recombinase hDmc1 forms ring structures and interacts with hRad51

West, SC, Hajibagheri, N, Davies, AA, Masson, JY, Benson, FE, Stasiak, AZ, Stasiak, A, Van Dyck, E

EMBO J 1999
8929543 Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro

West, SC, Benson, FE, Baumann, P

Cell 1996
17981954 Analysis of replication protein A (RPA) in human spermatogenesis

Turek, PJ, Ko, E, Martin, RH, Oliver-Bonet, M, Campillo, M

Mol Hum Reprod 2007
9450758 Synergistic actions of Rad51 and Rad52 in recombination and DNA repair

West, SC, Benson, FE, Baumann, P

Nature 1998
16123081 Temporal progression of recombination in human males

Sun, F, Turek, PJ, Ko, E, Martin, RH, Oliver-Bonet, M

Mol Hum Reprod 2005
9311981 Distribution of the Rad51 recombinase in human and mouse spermatocytes

West, SC, Hultén, MA, Benson, FE, Barlow, AL

EMBO J 1997
18256600 Formation and branch migration of Holliday junctions mediated by eukaryotic recombinases

Iwasaki, H, Kurokawa, Y, Murayama, Y, Mayanagi, K

Nature 2008
Catalyst Activity

DNA strand exchange activity of Meiotic single-stranded DNA complex [nucleoplasm]

This event is regulated
Inferred From
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