ATR phosphorylates Histone H2A.X at unsynapsed regions

Stable Identifier
R-HSA-912470
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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ATR phosphorylates Histone H2A.X at unsynapsed regions
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The ATR kinase phosphorylates histone H2A.X at serine 139 (Ward and Chen 2001, Garcia-Cruz et al. 2009).

Literature References
PubMed ID Title Journal Year
11673449 Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress

Chen, J, Ward, IM

J Biol Chem 2001
19146767 ATR, BRCA1 and gammaH2AX localize to unsynapsed chromosomes at the pachytene stage in human oocytes

Garcia Caldés, M, Robles, P, Scherthan, H, Garcia-Cruz, R, Roig, I

Reprod Biomed Online 2009
Participants
Input
Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of Synaptonemal Complex:BRCA1:ATR [nucleoplasm]

Physical Entity
Synaptonemal Complex:BRCA1:ATR [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Inferred From
Atr Phosphorylates Histone H2A.X at Unsynapsed Regions (Mus musculus)
Authored
May, B  (2010-07-19)
Reviewed
Bolcun-Filas, E  (2011-02-25)
Lyndaker, A  (2011-02-25)
Holloway, JK  (2011-02-05)
Schimenti, JC  (2011-02-05)
Strong, E  (2011-02-25)
Cohen, PE  (2011-02-05)
Created
May, B  (2010-07-09)
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