Reactome | GRB2:GAB2 [cytosol]

GRB2:GAB2 [cytosol]

Stable Identifier

R-HSA-912522

Type

Complex

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by CSF1 (M-CSF) in myeloid cells (Homo sapiens)
    - PIK3R1:PIK3CA,B,D (PI3K), PLCG2 (PLCgamma2), SHC1 (SHC), PTPN11 (SHP2), GRB2:GAB2, GRB2:GAB3, GRAP2 (MONA), CBL:GRB2, INPP5D (SHIP1), INPPL1 (SHIP2) bind PolyUb,p-8Y-CSF1R and are activated (Homo sapiens)
      - GRB2:GAB2 [cytosol] (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-2 family signaling (Homo sapiens)
      - Interleukin receptor SHC signaling (Homo sapiens)
        
        Phosphorylated SHC1 recruits GRB2:GAB2 (Homo sapiens)
        
        GRB2:GAB2 [cytosol] (Homo sapiens)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        GRB2:GAB2 [cytosol] (Homo sapiens)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        GRB2:GAB2 [cytosol] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        GRB2:GAB2 [cytosol] (Homo sapiens)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        GRB2:GAB2 [cytosol] (Homo sapiens)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Homo sapiens)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        GRB2:GAB2 [cytosol] (Homo sapiens)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        GRB2:GAB2 [cytosol] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        GRB2:GAB2 [cytosol] (Homo sapiens)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        GRB2:GAB2 [cytosol] (Homo sapiens)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Homo sapiens)
      - Interleukin receptor SHC signaling (Homo sapiens)
        
        Phosphorylated SHC1 recruits GRB2:GAB2 (Homo sapiens)
        
        GRB2:GAB2 [cytosol] (Homo sapiens)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        GRB2:GAB2 [cytosol] (Homo sapiens)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        GRB2:GAB2 [cytosol] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        GRB2:GAB2 [cytosol] (Homo sapiens)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        GRB2:GAB2 [cytosol] (Homo sapiens)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Homo sapiens)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        GRB2:GAB2 [cytosol] (Homo sapiens)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        GRB2:GAB2 [cytosol] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        GRB2:GAB2 [cytosol] (Homo sapiens)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        GRB2:GAB2 [cytosol] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
19523899	Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2 Harkiolaki, M, Tsirka, T, Lewitzky, M, Simister, PC, Joshi, D, Bird, LE, Jones, EY, O'Reilly, N, Feller, SM	Structure	2009

Participants

components

Participates

as an input of

as a component of

Inferred To

GRB2:GAB2 [cytosol] (Bos taurus)

GRB2:GAB2 [cytosol] (Canis familiaris)

GRB2:GAB2 [cytosol] (Gallus gallus)

GRB2:GAB2 [cytosol] (Mus musculus)

GRB2:GAB2 [cytosol] (Rattus norvegicus)

GRB2:GAB2 [cytosol] (Sus scrofa)