Reactome | p-Y-GAB2 [cytosol]

p-Y-GAB2 [cytosol]

Stable Identifier

R-HSA-912529

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

pY-GAB2, GRB2-associated-binding protein 2, GAB2_HUMAN, GAB2

Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - FLT3 Signaling (Homo sapiens)
    - Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Homo sapiens)
      - Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Homo sapiens)
        
        Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Homo sapiens)
        
        Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
        
        p-Y-GAB2 [cytosol] (Homo sapiens)
      - Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Homo sapiens)
        
        Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
        
        p-Y-GAB2 [cytosol] (Homo sapiens)
    - Active FLT3:GRB2:p-Y-GAB2 binds PIK3R1 (Homo sapiens)
      - Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
        
        p-Y-GAB2 [cytosol] (Homo sapiens)
      - Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Homo sapiens)
        
        Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
        
        p-Y-GAB2 [cytosol] (Homo sapiens)
    - Active FLT3:GRB2:p-Y-GAB2 binds PTPN11 (Homo sapiens)
      - Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
        
        p-Y-GAB2 [cytosol] (Homo sapiens)
      - Active FLT3:GRB2:p-Y-GAB2:PTPN11 [plasma membrane] (Homo sapiens)
        
        Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
        
        p-Y-GAB2 [cytosol] (Homo sapiens)
    - GAB2 in Active FLT3:GRB2:GAB2 is phosphorylated (Homo sapiens)
      - Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
        
        p-Y-GAB2 [cytosol] (Homo sapiens)
    - STAT5 Activation (Homo sapiens)
      - Activator phosphorylates STAT5 (Homo sapiens)
        
        Activators of STAT5:STAT5 [cytosol] (Homo sapiens)
        
        Activators of STAT5 [cytosol] (Homo sapiens)
        
        Active FLT3:GRB2:p-Y-GAB2:PTPN11 [plasma membrane] (Homo sapiens)
        
        Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
        
        p-Y-GAB2 [cytosol] (Homo sapiens)
        
        Activators of STAT5:p-STAT5 [cytosol] (Homo sapiens)
        
        Activators of STAT5 [cytosol] (Homo sapiens)
        
        Active FLT3:GRB2:p-Y-GAB2:PTPN11 [plasma membrane] (Homo sapiens)
        
        Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
        
        p-Y-GAB2 [cytosol] (Homo sapiens)
      - Activators bind STAT5 (Homo sapiens)
        
        Activators of STAT5 [cytosol] (Homo sapiens)
        
        Active FLT3:GRB2:p-Y-GAB2:PTPN11 [plasma membrane] (Homo sapiens)
        
        Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
        
        p-Y-GAB2 [cytosol] (Homo sapiens)
        
        Activators of STAT5:STAT5 [cytosol] (Homo sapiens)
        
        Activators of STAT5 [cytosol] (Homo sapiens)
        
        Active FLT3:GRB2:p-Y-GAB2:PTPN11 [plasma membrane] (Homo sapiens)
        
        Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
        
        p-Y-GAB2 [cytosol] (Homo sapiens)
      - p-STAT5 dissociates from activator:STAT5 complex (Homo sapiens)
        
        Activators of STAT5 [cytosol] (Homo sapiens)
        
        Active FLT3:GRB2:p-Y-GAB2:PTPN11 [plasma membrane] (Homo sapiens)
        
        Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
        
        p-Y-GAB2 [cytosol] (Homo sapiens)
        
        Activators of STAT5:p-STAT5 [cytosol] (Homo sapiens)
        
        Activators of STAT5 [cytosol] (Homo sapiens)
        
        Active FLT3:GRB2:p-Y-GAB2:PTPN11 [plasma membrane] (Homo sapiens)
        
        Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
        
        p-Y-GAB2 [cytosol] (Homo sapiens)
  - Signaling by CSF1 (M-CSF) in myeloid cells (Homo sapiens)
    - CSF1R-associated PLCG2 hydrolyzes phosphatidylcholine (Homo sapiens)
      - CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:p-Y-CBL:GRB2:SOS1:p-Y-GAB2:p-Y-GAB3:GRAP2:INPP5D:INPPL1:PI3K:PTPN11:p-Y-SHC1:p-Y-PLCG2 [plasma membrane] (Homo sapiens)
        
        GRB2:p-Y-GAB2 [cytosol] (Homo sapiens)
        
        p-Y-GAB2 [cytosol] (Homo sapiens)
    - CSF1R-associated phosphatidylinositol 3-kinase (PI3K) phosphorylates PI(4,5)P2 (Homo sapiens)
      - CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:p-Y-CBL:GRB2:SOS1:p-Y-GAB2:p-Y-GAB3:GRAP2:INPP5D:INPPL1:PI3K:PTPN11:p-Y-SHC1:p-Y-PLCG2 [plasma membrane] (Homo sapiens)
        
        GRB2:p-Y-GAB2 [cytosol] (Homo sapiens)
        
        p-Y-GAB2 [cytosol] (Homo sapiens)
    - PIK3R1:PIK3CA,B,G (PI3K), PLCG2 (PLCgamma2), SHC1 (SHC), PTPN11 (SHP2), GRB2:GAB2, GRB2:GAB3, GRAP2 (MONA), CBL:GRB2, INPP5D (SHIP1), INPPL1 (SHIP2) bind PolyUb,p-8Y-CSF1R and are activated (Homo sapiens)
      - CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:p-Y-CBL:GRB2:SOS1:p-Y-GAB2:p-Y-GAB3:GRAP2:INPP5D:INPPL1:PI3K:PTPN11:p-Y-SHC1:p-Y-PLCG2 [plasma membrane] (Homo sapiens)
        
        GRB2:p-Y-GAB2 [cytosol] (Homo sapiens)
        
        p-Y-GAB2 [cytosol] (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-2 family signaling (Homo sapiens)
      - Interleukin receptor SHC signaling (Homo sapiens)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Homo sapiens)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
        
        GRB2:p-Y-GAB2 [cytosol] (Homo sapiens)
        
        p-Y-GAB2 [cytosol] (Homo sapiens)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
        
        GRB2:p-Y-GAB2 [cytosol] (Homo sapiens)
        
        p-Y-GAB2 [cytosol] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
        
        GRB2:p-Y-GAB2 [cytosol] (Homo sapiens)
        
        p-Y-GAB2 [cytosol] (Homo sapiens)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
        
        GRB2:p-Y-GAB2 [cytosol] (Homo sapiens)
        
        p-Y-GAB2 [cytosol] (Homo sapiens)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
        
        GRB2:p-Y-GAB2 [cytosol] (Homo sapiens)
        
        p-Y-GAB2 [cytosol] (Homo sapiens)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
        
        GRB2:p-Y-GAB2 [cytosol] (Homo sapiens)
        
        p-Y-GAB2 [cytosol] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
        
        GRB2:p-Y-GAB2 [cytosol] (Homo sapiens)
        
        p-Y-GAB2 [cytosol] (Homo sapiens)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
        
        GRB2:p-Y-GAB2 [cytosol] (Homo sapiens)
        
        p-Y-GAB2 [cytosol] (Homo sapiens)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Homo sapiens)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
        
        GRB2:p-Y-GAB2 [cytosol] (Homo sapiens)
        
        p-Y-GAB2 [cytosol] (Homo sapiens)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
        
        GRB2:p-Y-GAB2 [cytosol] (Homo sapiens)
        
        p-Y-GAB2 [cytosol] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
        
        GRB2:p-Y-GAB2 [cytosol] (Homo sapiens)
        
        p-Y-GAB2 [cytosol] (Homo sapiens)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
        
        GRB2:p-Y-GAB2 [cytosol] (Homo sapiens)
        
        p-Y-GAB2 [cytosol] (Homo sapiens)
      - Interleukin-15 signaling (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2 (Homo sapiens)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
        
        p-Y-GAB2 [cytosol] (Homo sapiens)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Homo sapiens)
      - Interleukin receptor SHC signaling (Homo sapiens)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Homo sapiens)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
        
        GRB2:p-Y-GAB2 [cytosol] (Homo sapiens)
        
        p-Y-GAB2 [cytosol] (Homo sapiens)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
        
        GRB2:p-Y-GAB2 [cytosol] (Homo sapiens)
        
        p-Y-GAB2 [cytosol] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
        
        GRB2:p-Y-GAB2 [cytosol] (Homo sapiens)
        
        p-Y-GAB2 [cytosol] (Homo sapiens)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
        
        GRB2:p-Y-GAB2 [cytosol] (Homo sapiens)
        
        p-Y-GAB2 [cytosol] (Homo sapiens)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
        
        GRB2:p-Y-GAB2 [cytosol] (Homo sapiens)
        
        p-Y-GAB2 [cytosol] (Homo sapiens)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
        
        GRB2:p-Y-GAB2 [cytosol] (Homo sapiens)
        
        p-Y-GAB2 [cytosol] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
        
        GRB2:p-Y-GAB2 [cytosol] (Homo sapiens)
        
        p-Y-GAB2 [cytosol] (Homo sapiens)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
        
        GRB2:p-Y-GAB2 [cytosol] (Homo sapiens)
        
        p-Y-GAB2 [cytosol] (Homo sapiens)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Homo sapiens)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
        
        GRB2:p-Y-GAB2 [cytosol] (Homo sapiens)
        
        p-Y-GAB2 [cytosol] (Homo sapiens)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
        
        GRB2:p-Y-GAB2 [cytosol] (Homo sapiens)
        
        p-Y-GAB2 [cytosol] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
        
        GRB2:p-Y-GAB2 [cytosol] (Homo sapiens)
        
        p-Y-GAB2 [cytosol] (Homo sapiens)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
        
        GRB2:p-Y-GAB2 [cytosol] (Homo sapiens)
        
        p-Y-GAB2 [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - PIP3 activates AKT signaling (Homo sapiens)
    - Negative regulation of the PI3K/AKT network (Homo sapiens)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
        
        PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Homo sapiens)
        
        Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Homo sapiens)
        
        Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
        
        p-Y-GAB2 [cytosol] (Homo sapiens)
    - PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
      - Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Homo sapiens)
        
        Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Homo sapiens)
        
        Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
        
        p-Y-GAB2 [cytosol] (Homo sapiens)
- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by Insulin receptor (Homo sapiens)
    - Insulin receptor signalling cascade (Homo sapiens)
      - IRS-mediated signalling (Homo sapiens)
        
        PI3K Cascade (Homo sapiens)
        
        PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
        
        PI3K-containing complexes [cytosol] (Homo sapiens)
        
        Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Homo sapiens)
        
        Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
        
        p-Y-GAB2 [cytosol] (Homo sapiens)
  - Signaling by SCF-KIT (Homo sapiens)
    - Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Homo sapiens)
      - PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        p-Y-GAB2 [cytosol] (Homo sapiens)
      - p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        p-Y-GAB2 [cytosol] (Homo sapiens)
    - Phosphorylation of GAB2 by SFKs (Homo sapiens)
      - p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        p-Y-GAB2 [cytosol] (Homo sapiens)
    - Synthesis of PIP3 from PIP2 by PI3K (Homo sapiens)
      - PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        p-Y-GAB2 [cytosol] (Homo sapiens)
  - Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)
    - IGF1R signaling cascade (Homo sapiens)
      - IRS-related events triggered by IGF1R (Homo sapiens)
        
        IRS-mediated signalling (Homo sapiens)
        
        PI3K Cascade (Homo sapiens)
        
        PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
        
        PI3K-containing complexes [cytosol] (Homo sapiens)
        
        Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Homo sapiens)
        
        Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
        
        p-Y-GAB2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UQC2 GAB2

Gene Names

GAB2, KIAA0571

Chain

chain:1-676

Reference Genes

BioGPS Gene:9846 GAB2

COSMIC (genes):GAB2 GAB2

CTD Gene:9846 GAB2

dbSNP Gene:9846 GAB2

ENSEMBL:ENSG00000033327 GAB2

ENSEMBL:ENSG00000033327.13 GAB2

HGNC:14458 GAB2

KEGG Gene (Homo sapiens):9846 GAB2

Monarch:9846 GAB2

NCBI Gene:9846 GAB2

OMIM:606203 GAB2

UCSC:Q9UQC2 GAB2

Reference Transcript

Other Identifiers

11724867_a_at

11737624_a_at

16742647

203853_PM_s_at

203853_s_at

3383228

3383229

3383230

3383231

3383232

3383233

3383234

3383235

3383236

3383237

3383238

3383239

3383243

3383244

3383258

3383259

3383278

3383295

3383296

35253_at

7950671

9846

A_23_P203743

A_24_P98843

GE53283

GO:0002376

GO:0005068

GO:0005515

GO:0005547

GO:0005737

GO:0005829

GO:0005886

GO:0007165

GO:0007169

GO:0008284

GO:0008289

GO:0016020

GO:0016192

GO:0023052

GO:0030154

GO:0030316

GO:0043306

GO:0043325

GO:0048015

GO:0048856

GO:0060090

HMNXSV003056815

ILMN_1665964

ILMN_1728746

ILMN_1815758

PH_hs_0002620

TC11002136.hg

g6912459_3p_a_at

Participates

as a component of

Other forms of this molecule

p-Y643-GAB2 [cytosol]

p-5Y-GAB2 [cytosol]

p-Y452,Y476,Y584-GAB2 [cytosol]

GAB2 [cytosol]

Inferred To

Ghost homologue of p-Y-GAB2 [cytosol] (Xenopus tropicalis)

phospho-Gab2 [cytosol] (Mus musculus)

phospho-Gab2 [cytosol] (Rattus norvegicus)

phospho-GAB2 [cytosol] (Bos taurus)

phospho-GAB2 [cytosol] (Sus scrofa)

phospho-p-Y-GAB2 [cytosol] (Canis familiaris)

phospho-p-Y-GAB2 [cytosol] (Danio rerio)

phospho-p-Y-GAB2 [cytosol] (Gallus gallus)

phospho-dos [cytosol] (Drosophila melanogaster)

Modified Residues

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_536739.1, NP_036428.1, XP_006718816.1

OpenTargets

ENSG00000033327

GeneCards

Q9UQC2

HPA

ENSG00000033327-GAB2

Ensembl

ENST00000361507, ENSP00000343959, ENSG00000033327, ENST00000340149, ENSP00000354952

PRO

Q9UQC2

Pharos - Targets

Q9UQC2

Orphanet

28320

PDB

6ZVE, 6ZVB, 5EXA, 6Y3R, 2W0Z, 6ZVC, 2VWF, 5EWZ, 6Y3S, 6ZVD

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.95	15
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.669	3
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.643	3
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.643	4
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.643	4
UniProt:Q06124 PTPN11	4	p-Y542-PTPN11 [cytosol] (R-HSA-1369081) PTPN11 [nucleoplasm] (R-HSA-8937745) PTPN11 [cytosol] (R-HSA-162563) p-Y542,Y580-PTPN11 [cytosol] (R-HSA-162573)	0.643	4
UniProt:P27986 PIK3R1	16	p-Y-PIK3R1 [cytosol] (R-HSA-9680647) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.564	2
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.558	4
UniProt:Q8WZ73-3 Q8WZ733			0.556	3
UniProt:P11117 PPAL			0.556	3
UniProt:A0A024R8L2 A0A024R8L2			0.556	3
UniProt:P08865 RPSA	2	RPSA [nucleoplasm] (R-HSA-6798722) RPSA [cytosol] (R-HSA-72389)	0.556	3
UniProt:O75791 GRAP2	1	GRAP2 [cytosol] (R-HSA-202367)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:P29353 SHC1	5	SHC1 [cytosol] (R-HSA-74680) p-Y427-SHC1 [cytosol] (R-HSA-74684) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y-SHC1 [cytosol] (R-HSA-162568) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321)	0.544	2
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.527	2
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.527	3

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