UBP43 binds IFNAR2 and prevents JAK1 interaction

Stable Identifier
R-HSA-912685
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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UBP43 binds IFNAR2 and prevents JAK1 interaction
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UBP43, a type I IFN-inducible cysteine protease acts as a negative regulator of type I IFN signaling. UBP43 binds directly to IFNAR2 and blocks JAK-receptor interaction leading to inhibition of downstream phosphorylation and other signaling events.
Literature References
PubMed ID Title Journal Year
16710296 UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity

Fuchs, SY, Malakhova, OA, Zhang, DE, Luo, JK, Kim, KI, Zou, W, Shuai, K, Kumar, KG

EMBO J 2006
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Orthologous Events
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Authored
Garapati, P V  (2010-07-07)
Reviewed
Abdul-Sater, AA  (2010-08-17)
Schindler, C  (2010-08-17)
Created
Garapati, P V  (2010-07-12)
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