CBL binds VAV

Stable Identifier
R-HSA-912727
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Cbl and Vav interact in thymocytes and peripheral T cells (Marengere et al. 1997). Cbl phosphorylated at Y700 binds Vav1 in 293T cells, leading to Vav ubiquitinylation and proteolytic degradation.
Literature References
PubMed ID Title Journal Year
9200440 Proto-oncoprotein Vav interacts with c-Cbl in activated thymocytes and peripheral T cells

Penninger, JM, Kozieradzki, I, Marengère, LE, Veillette, A, Mak, TW, Mirtsos, C

J Immunol 1997
12881521 Cbl-mediated ubiquitinylation and negative regulation of Vav

Miura-Shimura, Y, Rottapel, R, Rao, NL, Duan, L, Reddi, AL, Band, H, Druker, BJ, Shimura, H, Tsygankov, A, Band, V

J Biol Chem 2003
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