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DHX58 [cytosol]
Stable Identifier
R-HSA-913540
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
LGP2, Probable ATP-dependent RNA helicase DHX58, DHX58_HUMAN
Locations in the PathwayBrowser for interactor UniProt:P56537 IF6
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
viral dsRNA binds DDX58 (Homo sapiens)
DHX58 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96C10 DHX58
Gene Names
DHX58, D11LGP2E, LGP2
Chain
chain:1-678
Reference Genes
BioGPS Gene:79132 DHX58
COSMIC (genes):DHX58 DHX58
CTD Gene:79132 DHX58
dbSNP Gene:79132 DHX58
ENSEMBL:ENSG00000108771 DHX58
HGNC:29517 DHX58
KEGG:hsa:79132 DHX58
Monarch:79132 DHX58
NCBI Gene:79132 DHX58
OMIM:608588 DHX58
UCSC:Q96C10 DHX58
Reference Transcript
RefSeq:NM_024119.2 DHX58
RefSeq:XM_017025060.1 DHX58
RefSeq:XM_017025059.1 DHX58
Other Identifiers
11721897_a_at
11749497_a_at
11750742_a_at
11762013_at
16844999
219364_PM_at
219364_at
3757603
3757604
3757605
3757606
3757607
3757608
3757609
3757611
3757612
3757613
3757614
3757615
3757616
3757617
3757618
3757619
3757620
3757621
3757622
3757623
3757624
3757625
3757626
3757627
3757628
3757629
62214_at
79132
8015511
A_23_P38346
GE87394
GO:0002376
GO:0002753
GO:0003677
GO:0003723
GO:0003724
GO:0003725
GO:0003727
GO:0003824
GO:0004386
GO:0005515
GO:0005524
GO:0005737
GO:0008270
GO:0009615
GO:0009617
GO:0016787
GO:0016887
GO:0032480
GO:0032481
GO:0039534
GO:0039536
GO:0045087
GO:0045088
GO:0045824
GO:0046872
GO:0051607
GO:0098542
GO:0140098
GO:0140374
GO:0140640
GO:0140657
GO:1900245
GO:1900246
HMNXSV003012146
ILMN_1678422
PH_hs_0003649
TC17001523.hg
g13129141_3p_at
This entity regulates
Negatively
viral dsRNA binds DDX58
(Homo sapiens)
Cross References
RefSeq
XP_016880549.1
,
NP_077024.2
,
XP_016880548.1
Guide to Pharmacology - Targets
2922
ENSEMBL
ENST00000251642
,
ENSP00000251642
OpenTargets
ENSG00000108771
HPA
ENSG00000108771-DHX58
PRO
Q96C10
Pharos - Targets
Q96C10
HMDB Protein
HMDBP11705
PDB
2RQA
,
3EQT
,
2W4R
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NUL3 STAU2
0.499
2
UniProt:P56537 IF6
0.499
2
UniProt:O15226 NKRF
0.499
2
UniProt:Q7L2E3 DHX30
0.499
2
UniProt:Q9UKV8 AGO2
2
AGO2 [cytosol]
(R-HSA-209723)
AGO2 [nucleoplasm]
(R-HSA-5578701)
0.499
2
UniProt:Q9UPY3 DICER1
1
DICER1 [cytosol]
(R-HSA-203820)
0.499
2
UniProt:P19525 EIF2AK2
5
EIF2AK2 [cytosol]
(R-HSA-168699)
p-EIF2AK2 [nucleoplasm]
(R-HSA-9836332)
p-EIF2AK2 [cytosol]
(R-HSA-9833834)
ISG15-EIF2AK2 [cytosol]
(R-HSA-9833968)
SUMO-EIF2AK2 [cytosol]
(R-HSA-9834829)
0.499
2
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