Reactome | GalNAc-MUC1(24-1255) [Golgi lumen]

GalNAc-MUC1(24-1255) [Golgi lumen]

Stable Identifier

R-HSA-913642

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi lumen

Synonyms

GalNAc-MUC1, Tn antigen (MUC1), N-acetyl-D-galactosaminyl-mucin-1, MUC1, MUC1_HUMAN

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External Reference Information

External Reference

UniProt:P15941 MUC1

Gene Names

MUC1, PUM

Chain

signal peptide:1-23, chain:24-1255, chain:24-1097, chain:1098-1255

Reference Genes

COSMIC (genes):MUC1 MUC1

dbSNP Gene:4582 MUC1

ENSEMBL:ENSG00000185499 MUC1

Participates

as a member of

Tn antigens [Golgi lumen] (Homo sapiens)

Other forms of this molecule

MUC1(24-1255) [plasma membrane]

Core 8 (MUC1) [Golgi lumen]

Core 2S (MUC1) [Golgi lumen]

Core 5 (MUC1) [Golgi lumen]

Core 4 (MUC1) [Golgi lumen]

Core 3 (MUC1) [Golgi lumen]

Core 7 (MUC1) [Golgi lumen]

extended Core 6 (MUC1) [Golgi lumen]

Core 6 (MUC1) [Golgi lumen]

MUC1(24-1255) [Golgi lumen]

Disialyl T-antigen (MUC1) [Golgi lumen]

Sialyl T-antigen (MUC1) [Golgi lumen]

Sialyl-2,3 T-antigen (MUC1) [Golgi lumen]

T-antigen (MUC1) [Golgi lumen]

Sialyl Tn antigen (MUC1) [Golgi lumen]

Core 2a (MUC1) [Golgi lumen]

Core 2 (MUC1) [Golgi lumen]

GalNAc-MUC1(24-1255) [plasma membrane]

Inferred To

muc1 [Golgi lumen] (Xenopus tropicalis)

Muc1 [Golgi lumen] (Mus musculus)

Muc1 [Golgi lumen] (Rattus norvegicus)

cnp-2 [Golgi lumen] (Caenorhabditis elegans)

MUC1 [Golgi lumen] (Bos taurus)

MUC1 [Golgi lumen] (Canis familiaris)

MUC1 [Golgi lumen] (Sus scrofa)

Modified Residues

Name

O-(N-acetylamino)galactosyl-L-serine at unknown position

PsiMod Name

O-(N-acetylamino)galactosyl-L-serine

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-(N-acetylaminogalactosyl)-L-serine.

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.819	6
UniProt:P12931 SRC	6	MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-SRC [plasma membrane] (R-HSA-8876922) p-Y419-SRC [cytosol] (R-HSA-8964276) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [nucleoplasm] (R-HSA-8937690)	0.748	5
UniProt:P26368 U2AF2	2	U2AF2 [nucleoplasm] (R-HSA-71987) 5OHK15,276-U2AF2 [nucleoplasm] (R-HSA-9630011)	0.471	2
UniProt:P00519 ABL1	6	p-S456-ABL1 [nucleoplasm] (R-HSA-5686576) ABL1 [nucleoplasm] (R-HSA-5686579) p-Y226,Y393-ABL1 [cytosol] (R-HSA-8942610) ABL1 [cytosol] (R-HSA-375987) p-Y226,Y393-ABL1 [nucleoplasm] (R-HSA-8985251) p-Y393-ABL1 [cytosol] (R-HSA-9865161)	0.463	4

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