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14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2
Stable Identifier
R-HSA-913993
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Rap1 signalling (Homo sapiens)
14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Homo sapiens)
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RAP1GAP2 binds 14-3-3 proteins beta and zeta, inhibiting its GAP activity for Rap1. This effect is diminished by Ser-7 phosphorylation of RAP1GAP2 by cGMP- and cAMP-dependent protein kinases (PKG and PKA respectively), which inhibits the binding of 14-3-3 proteins beta and zeta to Rap1GAP2. 14-3-3 binding does not appear to alter the GTPase-activating function of Rap1GAP2 in vitro, but attenuates Rap1GAP2 mediated inhibition of cell adhesion (Hoffmeister et al. 2008).
Literature References
PubMed ID
Title
Journal
Year
18039662
Cyclic nucleotide-dependent protein kinases inhibit binding of 14-3-3 to the GTPase-activating protein Rap1GAP2 in platelets
Neumüller, O
,
Riha, P
,
Schultess, J
,
Danielewski, O
,
Smolenski, AP
,
Hoffmeister, M
J Biol Chem
2008
Participants
Input
14-3-3 beta, zeta [cytosol]
(Homo sapiens)
RAP1GAP2 [cytosol]
(Homo sapiens)
Output
RAP1GAP2:14-3-3beta, zeta [cytosol]
(Homo sapiens)
Participates
as an event of
Rap1 signalling (Homo sapiens)
This event is regulated
Negatively by
Regulator
p-S7-RAP1GAP2 [cytosol]
(Homo sapiens)
Orthologous Events
14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Bos taurus)
14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Caenorhabditis elegans)
14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Canis familiaris)
14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Danio rerio)
14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Drosophila melanogaster)
14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Gallus gallus)
14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Mus musculus)
14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Rattus norvegicus)
14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Sus scrofa)
14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Xenopus tropicalis)
Authored
Akkerman, JW (2009-06-03)
Reviewed
Heemskerk, JW (2010-09-01)
Created
Jupe, S (2010-07-20)
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