PKA/PKG phosphorylate Rap1GAP2

Stable Identifier
R-HSA-913996
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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PKA/PKG phosphorylate Rap1GAP2
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cGMP and cAMP dependent protein kinases (PKG and PKA respectively) phosphorylate the Rap1 GTPase activating RAP1GAP2 at serine 7 (Schultess et al. 2007). This reduces the binding of inhibitory 14-3-3 proteins to RAP1GAP2.

Literature References
PubMed ID Title Journal Year
15632203 Rap1GAP2 is a new GTPase-activating protein of Rap1 expressed in human platelets

Schultess, J, Danielewski, O, Smolenski, AP

Blood 2005
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Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of PKA catalytic subunits, PKG type I [cytosol]

Physical Entity
PKA catalytic subunits, PKG type I [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
PKA/PKG phosphorylate Rap1GAP2 (Bos taurus)
PKA/PKG phosphorylate Rap1GAP2 (Caenorhabditis elegans)
PKA/PKG phosphorylate Rap1GAP2 (Canis familiaris)
PKA/PKG phosphorylate Rap1GAP2 (Danio rerio)
PKA/PKG phosphorylate Rap1GAP2 (Dictyostelium discoideum)
PKA/PKG phosphorylate Rap1GAP2 (Drosophila melanogaster)
PKA/PKG phosphorylate Rap1GAP2 (Gallus gallus)
PKA/PKG phosphorylate Rap1GAP2 (Mus musculus)
PKA/PKG phosphorylate Rap1GAP2 (Rattus norvegicus)
PKA/PKG phosphorylate Rap1GAP2 (Sus scrofa)
PKA/PKG phosphorylate Rap1GAP2 (Xenopus tropicalis)
Authored
Akkerman, JW  (2009-06-03)
Reviewed
Heemskerk, JW  (2010-09-01)
Created
Jupe, S  (2010-07-20)
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