Reactome | p-S585-CSF2RB [plasma membrane]

p-S585-CSF2RB [plasma membrane]

Stable Identifier

R-HSA-914170

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

p-S585-IL3RB, p(S585)-GM-CSF/IL-3/IL-5 receptor common beta chain, Cytokine receptor common subunit beta, CSF2RB, CD131

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Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Homo sapiens)
      - 14-3-3 zeta binding allows recruitment of PI3K (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Homo sapiens)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, p(S585)-Bc [plasma membrane] (Homo sapiens)
        
        GM-CSF:GM-CSF receptor alpha subunit:p(S585)-Common beta chain:JAK2 [plasma membrane] (Homo sapiens)
        
        p-S585-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        p-S585-CSF2RB [plasma membrane] (Homo sapiens)
        
        High affinity IL-3 receptor complex dimer, inactive JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:pS585-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        p-S585-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        p-S585-CSF2RB [plasma membrane] (Homo sapiens)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, p(S585)-Common beta chain [plasma membrane] (Homo sapiens)
        
        IL5 homodimer:IL5RA:p(S585)-Common beta chain:JAK2 [plasma membrane] (Homo sapiens)
        
        p-S585-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        p-S585-CSF2RB [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Homo sapiens)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, p(S585)-Bc [plasma membrane] (Homo sapiens)
        
        GM-CSF:GM-CSF receptor alpha subunit:p(S585)-Common beta chain:JAK2 [plasma membrane] (Homo sapiens)
        
        p-S585-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        p-S585-CSF2RB [plasma membrane] (Homo sapiens)
        
        High affinity IL-3 receptor complex dimer, inactive JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:pS585-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        p-S585-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        p-S585-CSF2RB [plasma membrane] (Homo sapiens)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, p(S585)-Common beta chain [plasma membrane] (Homo sapiens)
        
        IL5 homodimer:IL5RA:p(S585)-Common beta chain:JAK2 [plasma membrane] (Homo sapiens)
        
        p-S585-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        p-S585-CSF2RB [plasma membrane] (Homo sapiens)
      - IL3RB is phosphorylated on Ser-585 (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Homo sapiens)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, p(S585)-Bc [plasma membrane] (Homo sapiens)
        
        GM-CSF:GM-CSF receptor alpha subunit:p(S585)-Common beta chain:JAK2 [plasma membrane] (Homo sapiens)
        
        p-S585-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        p-S585-CSF2RB [plasma membrane] (Homo sapiens)
        
        High affinity IL-3 receptor complex dimer, inactive JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:pS585-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        p-S585-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        p-S585-CSF2RB [plasma membrane] (Homo sapiens)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, p(S585)-Common beta chain [plasma membrane] (Homo sapiens)
        
        IL5 homodimer:IL5RA:p(S585)-Common beta chain:JAK2 [plasma membrane] (Homo sapiens)
        
        p-S585-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        p-S585-CSF2RB [plasma membrane] (Homo sapiens)
      - p-S585-IL3RB binds 14-3-3 proteins (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Homo sapiens)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, p(S585)-Bc [plasma membrane] (Homo sapiens)
        
        GM-CSF:GM-CSF receptor alpha subunit:p(S585)-Common beta chain:JAK2 [plasma membrane] (Homo sapiens)
        
        p-S585-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        p-S585-CSF2RB [plasma membrane] (Homo sapiens)
        
        High affinity IL-3 receptor complex dimer, inactive JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:pS585-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        p-S585-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        p-S585-CSF2RB [plasma membrane] (Homo sapiens)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, p(S585)-Common beta chain [plasma membrane] (Homo sapiens)
        
        IL5 homodimer:IL5RA:p(S585)-Common beta chain:JAK2 [plasma membrane] (Homo sapiens)
        
        p-S585-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        p-S585-CSF2RB [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Homo sapiens)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, p(S585)-Bc [plasma membrane] (Homo sapiens)
        
        GM-CSF:GM-CSF receptor alpha subunit:p(S585)-Common beta chain:JAK2 [plasma membrane] (Homo sapiens)
        
        p-S585-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        p-S585-CSF2RB [plasma membrane] (Homo sapiens)
        
        High affinity IL-3 receptor complex dimer, inactive JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:pS585-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        p-S585-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        p-S585-CSF2RB [plasma membrane] (Homo sapiens)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, p(S585)-Common beta chain [plasma membrane] (Homo sapiens)
        
        IL5 homodimer:IL5RA:p(S585)-Common beta chain:JAK2 [plasma membrane] (Homo sapiens)
        
        p-S585-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        p-S585-CSF2RB [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P32927 CSF2RB

Gene Names

CSF2RB, IL3RB, IL5RB

Chain

signal peptide:1-16, chain:17-897

Reference Genes

BioGPS Gene:1439 CSF2RB

COSMIC (genes):CSF2RB CSF2RB

CTD Gene:1439 CSF2RB

dbSNP Gene:1439 CSF2RB

ENSEMBL:ENSG00000100368 CSF2RB

ENSEMBL_homo_sapiens_GENE:ENSG00000100368.15 CSF2RB

HGNC:2436 CSF2RB

KEGG Gene (Homo sapiens):1439 CSF2RB

Monarch:1439 CSF2RB

NCBI Gene:1439 CSF2RB

OMIM:138981 CSF2RB

UCSC:P32927 CSF2RB

Reference Transcript

Other Identifiers

1086_at

11722724_a_at

11722725_a_at

11758608_s_at

1439

16929677

205159_PM_at

205159_at

3429537

37493_at

37494_at

3944565

3944566

3944568

3944569

3944571

3944572

3944573

3944574

3944575

3944576

3944577

3944578

3944579

3944580

3944582

3944583

3944584

3944585

3944589

3944590

3944591

3944592

3944593

3944594

3944595

3944596

3944597

3944598

3944599

3944600

3944601

3944602

3944603

3944604

3944605

8072757

A_14_P106200

A_14_P135880

A_23_P120899

A_33_P3341442

GE57996

GE80082

GO:0002376

GO:0004896

GO:0004912

GO:0004914

GO:0005515

GO:0005886

GO:0007165

GO:0007259

GO:0007585

GO:0009897

GO:0015026

GO:0016020

GO:0016064

GO:0019221

GO:0023052

GO:0030526

GO:0032496

GO:0036016

GO:0038023

GO:0038043

GO:0038156

GO:0038157

GO:0060089

GO:0070665

HMNXSV003003586

HMNXSV003033609

Hs.285401.0.S2_3p_at

ILMN_1798475

M59941_at

PH_hs_0014775

TC22000271.hg

Participates

as a component of

p-S585-IL3RB:JAK2 [plasma membrane] (Homo sapiens)

Other forms of this molecule

CSF2RB S271L [plasma membrane]

p-Y593,Y628-CSF2RB [plasma membrane]

CSF2RB [plasma membrane]

p-Y593-CSF2RB [plasma membrane]

CSF2RB R211Efs*54 [plasma membrane]

Inferred To

phospho-Csf2rb [plasma membrane] (Mus musculus)

phospho-Csf2rb [plasma membrane] (Rattus norvegicus)

Homologues of p-S585-CSF2RB [plasma membrane] (Gallus gallus)

Homologues of p-S585-CSF2RB [plasma membrane] (Mus musculus)

phospho-p-S585-CSF2RB [plasma membrane] (Gallus gallus)

phospho-Csf2rb2 [plasma membrane] (Mus musculus)

phospho-CSF2RB [plasma membrane] (Bos taurus)

phospho-CSF2RB [plasma membrane] (Canis familiaris)

phospho-CSF2RB [plasma membrane] (Sus scrofa)

Modified Residues

Name

O-phospho-L-serine at 585

Coordinate

585

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_000386.1, XP_005261397.1

Guide to Pharmacology - Targets

2306

OpenTargets

ENSG00000100368

GeneCards

P32927

HPA

ENSG00000100368-CSF2RB

Ensembl

ENSG00000100368, ENST00000406230, ENSP00000384053, ENSP00000385271, ENST00000403662

PRO

P32927

Pharos - Targets

P32927

Orphanet

15812

HMDB Protein

HMDBP01696

PDB

4NKQ, 1GH7, 5DWU, 2GYS, 2NA9, 1EGJ, 1C8P, 2NA8

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P08700 IL3	1	IL3 [extracellular region] (R-HSA-450059)	0.589	2
UniProt:Q01344 IL5RA	1	IL5RA [plasma membrane] (R-HSA-450072)	0.589	3
UniProt:O60674 JAK2	8	p-Y1007,Y1008-JAK2 [cytosol] (R-HSA-9005327) p-JAK2 [cytosol] (R-HSA-210621) p-Y813-JAK2 [cytosol] (R-HSA-997248) JAK2 V617F [nucleoplasm] (R-HSA-5211269) JAK2 [endosome lumen] (R-HSA-2002372) p-12Y-JAK2 [cytosol] (R-HSA-2586516) p-Y1007-JAK2 [cytosol] (R-HSA-873799) JAK2 [cytosol] (R-HSA-210620)	0.564	4
UniProt:P05556 ITGB1	2	ITGB1 [endosome membrane] (R-HSA-9611157) ITGB1 [plasma membrane] (R-HSA-57596)	0.544	5
UniProt:Q06124 PTPN11	4	p-Y542-PTPN11 [cytosol] (R-HSA-1369081) PTPN11 [nucleoplasm] (R-HSA-8937745) PTPN11 [cytosol] (R-HSA-162563) p-Y542,Y580-PTPN11 [cytosol] (R-HSA-162573)	0.527	2
UniProt:P29353 SHC1	5	p-Y427-SHC1 [cytosol] (R-HSA-74684) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321) SHC1 [cytosol] (R-HSA-74680) p-Y-SHC1 [cytosol] (R-HSA-162568)	0.527	4
UniProt:P04141 CSF2 gene	1	CSF2 [extracellular region] (R-HSA-517562)	0.524	2
UniProt:P05113 IL5	1	IL5 [extracellular region] (R-HSA-447159)	0.524	2
UniProt:P29350 PTPN6	5	PTPN6 [tertiary granule lumen] (R-HSA-6800952) PTPN6 [extracellular region] (R-HSA-6806315) PTPN6 [specific granule lumen] (R-HSA-6799641) PTPN6 [nucleoplasm] (R-HSA-9008911) PTPN6 [cytosol] (R-HSA-197938)	0.471	2
UniProt:P27986 PIK3R1	16	p-Y-PIK3R1 [cytosol] (R-HSA-9680647) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.462	4

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