Reactome | SIKE1 [cytosol]

SIKE1 [cytosol]

Stable Identifier

R-HSA-916828

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Suppressor of IKBKE 1, SIKE1_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P30154 PPP2R1B

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        SARS-CoV-2-host interactions (Homo sapiens)
        
        SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
        
        TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 (Homo sapiens)
        
        SIKE1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BRV8 SIKE1

Gene Names

SIKE1, SIKE

Chain

chain:1-207

Reference Genes

BioGPS Gene:80143 SIKE1

COSMIC (genes):SIKE1 SIKE1

CTD Gene:80143 SIKE1

dbSNP Gene:80143 SIKE1

ENSEMBL:ENSG00000052723 SIKE1

HGNC:26119 SIKE1

KEGG:hsa:80143 SIKE1

Monarch:80143 SIKE1

NCBI Gene:80143 SIKE1

OMIM:611656 SIKE1

UCSC:Q9BRV8 SIKE1

Reference Transcript

Other Identifiers

11724011_at

11724012_at

16691302

204666_PM_s_at

204666_s_at

221705_PM_s_at

221705_s_at

228026_PM_at

228026_at

235294_PM_at

235294_at

2429339

2429340

2429341

2429342

2429343

2429344

2429346

2429347

2429348

2429349

2429350

2429351

2429352

33285_i_at

43914_r_at

47655_at

47656_g_at

72036_f_at

72038_r_at

7918847

80143

A_23_P85990

A_24_P937855

A_33_P3211734

A_33_P3383261

GE83072

GE88729

GO:0005515

GO:0005737

GO:0005829

GO:0019901

GO:0030674

GO:0031267

GO:0035331

GO:0060090

GO:0090443

HMNXSV003026754

Hs.222442.0.A1_3p_at

Hs.24808.0.A1_3p_at

ILMN_1653524

PH_hs_0022052

TC01003016.hg

g13376618_3p_at

g13543553_3p_s_at

Participates

as an output of

as a component of

TBK1/IKBKE:SIKE1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_079349.2, NP_001095866.1

OpenTargets

ENSG00000052723

ENSEMBL

ENSP00000358541, ENSP00000060969, ENST00000369528, ENST00000060969

HPA

ENSG00000052723-SIKE1

PRO

Q9BRV8

Pharos - Targets

Q9BRV8

GlyGen

Q9BRV8

PDB

6AKK, 6AKL, 6AKM

Interactors (28)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13033 STRN3			0.827	9
UniProt:Q14BN4 SLMAP			0.774	6
UniProt:P30153 PPP2R1A	2	PPP2R1A [cytosol] (R-HSA-165982) PPP2R1A [nucleoplasm] (R-HSA-165968)	0.745	7
UniProt:O43815 STRN	5	STRN [cytosol] (R-HSA-9037081) STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673902) p-11Y-STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673908) STRN(1-137)-ALK(1058-1620) fusion [cytosol] (R-HSA-9700485) STRN(1-137)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9700467)	0.725	6
UniProt:P67775 PPP2CA	4	PPP2CA [cytosol] (R-HSA-165971) PPP2CA [nucleoplasm] (R-HSA-165978) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) MeL-PPP2CA [nucleoplasm] (R-HSA-8857791)	0.725	5
UniProt:Q9NRL3 STRN4			0.69	5
UniProt:Q9Y3A3 PHOCN			0.69	6
UniProt:Q13033-2 STRN3			0.666	4
UniProt:O75558 STX11			0.666	4
UniProt:Q9ULQ0 STRP2			0.643	4
UniProt:Q9P289 STK26	3	MST4(306-416) [cytosol] (R-HSA-351903) MST4(1-305) [cytosol] (R-HSA-351855) MST4 [cytosol] (R-HSA-351918)	0.643	3
UniProt:O00506 STK25			0.643	3
UniProt:Q5VSL9 STRP1			0.643	5
UniProt:Q9Y6E0 STK24	4	STK24 [cytosol] (R-HSA-351829) STK24(1-313) [cytosol] (R-HSA-351892) STK24(314-443) [cytosol] (R-HSA-351898) STK24(1-313) [nucleoplasm] (R-HSA-351944)	0.643	4
UniProt:Q9NVK5 FGFR1OP2	2	FGFR1OP(1-132)-FGFR1(429-822) fusion [cytosol] (R-HSA-1606443) FGFR1OP(1-132)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1838998)	0.643	5
UniProt:Q9Y228 T3JAM			0.623	4
UniProt:Q96HA8 NTAQ1			0.556	3
UniProt:Q7L2Z9 CENPQ	2	CENPQ [nucleoplasm] (R-HSA-606327) CENPQ [cytosol] (R-HSA-375298)	0.556	3
UniProt:P78358 CTG1B			0.556	3
UniProt:P40222 TXLNA	1	TXLNA [cytosol] (R-HSA-449124)	0.556	3
UniProt:Q8N3L3 TXLNB			0.556	3
UniProt:O43439-4 CBFA2T2			0.556	3
UniProt:Q53FD0-2 ZC2HC1C			0.556	6
UniProt:Q9UIL1-3 SCOC			0.556	3
UniProt:O55106	1	Strn [cytosol] (R-MMU-9037081)	0.536	3
UniProt:P62714 PPP2CB	4	MeL-PPP2CB [nucleoplasm] (R-HSA-8857799) p-Y307-PPP2CB [cytosol] (R-HSA-8857935) PPP2CB [nucleoplasm] (R-HSA-165991) PPP2CB [cytosol] (R-HSA-165987)	0.527	3
UniProt:Q9BUL8 PDC10			0.527	3
UniProt:P30154 PPP2R1B	2	PPP2R1B [nucleoplasm] (R-HSA-166000) PPP2R1B [cytosol] (R-HSA-165980)	0.527	2

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