ESCRT Disassembly

Stable Identifier
Reaction [transition]
Homo sapiens
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Disassembly Phase
The AAA-ATPase, Vps4 disassembles ESCRT-III and catalyzes the final step of the MVB pathway. The microtubule interacting and trafficking (MIT) domain of Vps4 interacts directly with the C-terminal region of Vps2 (MIM1) and Vps20 (MIM2). The association of Vta1, which contains two MIT domains, greatly enhances the activity of Vps4. Please note that the recomended names of the Vacuolar protein sorting-associated proteins (Vps) are Charged multivesicular body proteins or CHMPs.

Literature References
PubMed ID Title Journal Year
15075231 ATPase-deficient hVPS4 impairs formation of internal endosomal vesicles and stabilizes bilayered clathrin coats on endosomal vacuoles

Klumperman, J, Sachse, M, Strous, GJ

J Cell Sci 2004
11563910 Mammalian cells express two VPS4 proteins both of which are involved in intracellular protein trafficking

Abts, HF, Schöning-Burkhardt, B, Müller, S, Beyer, A, Scheuring, S, Köhrer, K, Röhricht, RA

J Mol Biol 2001
Catalyst Activity

ATP hydrolysis activity of Vps/Vta1 [cytosol]

Orthologous Events
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