Reactome | Cargo Sequestration

Cargo Sequestration

Stable Identifier

R-HSA-917696

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endosome membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

ESCRT-0 recruits ESCRT-I and thereby initiates the MVB pathway. Cargo Sorting ESCRT-I is a heterotetramer consisting of Vps23, Vps28, Vps37 (VPS37A, VPS37B, VPS37C or VPS37D), and Mvb12/Ubap1 (MVB12A, MVB12B or UBAP1). The UEV domain of Vps23 binds ubiquitinated membrane proteins. Vps28 interacts with the GLUE domain of Vps36 in ESCRT-II. Cargo Sorting ESCRT-II is a heterotetramer formed of Vps36, Vps22, and two Vps25 molecules. The GLUE domain of Vps36 binds PI3P, Vps28, and ubiquitinated membrane proteins. Vps25 interacts with Vps20 of ESCRT-III.

Literature References

PubMed ID	Title	Journal	Year
15218037	The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding Ghaffarian, S, Stuchell, MD, Garrus, JE, Sundquist, WI, McKinnon, R, Muller, B, Stray, KM, Krausslich, HG, Morham, SG	J Biol Chem	2004
21757351	UBAP1 is a component of an endosome-specific ESCRT-I complex that is essential for MVB sorting Woodman, P, Rollinson, S, Stefani, F, Doyotte, A, Brownhill, K, Pickering-Brown, S, Zhang, L, Taylor, S, Donovan, J, Bennion, J	Curr. Biol.	2011