Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
CHMP4A [cytosol]
Stable Identifier
R-HSA-917733
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Charged multivesicular body protein 4a, CHM4A_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Autophagy (Homo sapiens)
Macroautophagy (Homo sapiens)
Autophagosome maturation (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP4 [cytosol] (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Nuclear Envelope (NE) Reassembly (Homo sapiens)
Sealing of the nuclear envelope (NE) by ESCRT-III (Homo sapiens)
CHMP7 binds CC2D1B (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B [nuclear envelope] (Homo sapiens)
LEMD2:ESCRT-III:IST1 [nuclear envelope] (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP4 [cytosol] (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
LEMD2:ESCRT-III:IST1 [nuclear envelope] (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP4 [cytosol] (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
CHMP7 binds CHMP4B, which recruits other subunits of the ESCRT-III complex (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
LEMD2:ESCRT-III:IST1 [nuclear envelope] (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP4 [cytosol] (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B [nuclear envelope] (Homo sapiens)
LEMD2:ESCRT-III:IST1 [nuclear envelope] (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP4 [cytosol] (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B:SPAST [nuclear envelope] (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B [nuclear envelope] (Homo sapiens)
LEMD2:ESCRT-III:IST1 [nuclear envelope] (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP4 [cytosol] (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B:SPAST [nuclear envelope] (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B [nuclear envelope] (Homo sapiens)
LEMD2:ESCRT-III:IST1 [nuclear envelope] (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP4 [cytosol] (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B:SPAST [nuclear envelope] (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B [nuclear envelope] (Homo sapiens)
LEMD2:ESCRT-III:IST1 [nuclear envelope] (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP4 [cytosol] (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B:SPAST:VPS4A [nuclear envelope] (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B:SPAST [nuclear envelope] (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B [nuclear envelope] (Homo sapiens)
LEMD2:ESCRT-III:IST1 [nuclear envelope] (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP4 [cytosol] (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B:SPAST:VPS4A [nuclear envelope] (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B:SPAST [nuclear envelope] (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B [nuclear envelope] (Homo sapiens)
LEMD2:ESCRT-III:IST1 [nuclear envelope] (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP4 [cytosol] (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HCMV Infection (Homo sapiens)
HCMV Late Events (Homo sapiens)
HCMV Final Envelopment (Homo sapiens)
ESCRT Regulator Complex [cytosol] (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP4 [cytosol] (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
HCMV Formation of Final Envelopment Complex (Homo sapiens)
ESCRT Regulator Complex [cytosol] (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP4 [cytosol] (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
HIV Infection (Homo sapiens)
HIV Life Cycle (Homo sapiens)
Late Phase of HIV Life Cycle (Homo sapiens)
Budding and maturation of HIV virion (Homo sapiens)
HIV Virion Budding (Homo sapiens)
Virion Budding Complex [plasma membrane] (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP4 [cytosol] (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
Recruitment Of HIV Virion Budding Machinery (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP4 [cytosol] (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
Virion Budding Complex [plasma membrane] (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP4 [cytosol] (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-1 Infection (Homo sapiens)
Translation of Replicase and Assembly of the Replication Transcription Complex (Homo sapiens)
Enhanced autophagosome formation (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP4 [cytosol] (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
Early SARS-CoV-2 Infection Events (Homo sapiens)
Translation of Replicase and Assembly of the Replication Transcription Complex (Homo sapiens)
Enhanced autophagosome formation (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP4 [cytosol] (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Regulated Necrosis (Homo sapiens)
Pyroptosis (Homo sapiens)
GSDMD forms ringâshaped oligomers (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP4 [cytosol] (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Endosomal Sorting Complex Required For Transport (ESCRT) (Homo sapiens)
ESCRT Disassembly (Homo sapiens)
CHMP4 [cytosol] (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
ESCRT-III/Cargo Complex [endosome membrane] (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP4 [cytosol] (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
MVB Vesicle Formation (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP4 [cytosol] (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
ESCRT-III/Cargo Complex [endosome membrane] (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP4 [cytosol] (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9BY43 CHMP4A
Gene Names
CHMP4A, C14orf123, SHAX2, CDA04, HSPC134
Chain
chain:1-222
Reference Genes
COSMIC (genes):CHMP4A CHMP4A
dbSNP Gene:29082 CHMP4A
ENSEMBL:ENSG00000254505 CHMP4A
Participates
as an output of
VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope (Homo sapiens)
as an input of
CHMP7 binds CHMP4B, which recruits other subunits of the ESCRT-III complex (Homo sapiens)
as a member of
CHMP4 [cytosol] (Homo sapiens)
Other forms of this molecule
CHMP4A [endosome membrane]
Inferred To
snf7 [cytosol]
(Schizosaccharomyces pombe)
CHMP4A [cytosol]
(Bos taurus)
CHMP4A [cytosol]
(Canis familiaris)
CHMP4A [cytosol]
(Sus scrofa)
SNF7 [cytosol]
(Saccharomyces cerevisiae)
chmp4 [cytosol]
(Dictyostelium discoideum)
vps-32.1 [cytosol]
(Caenorhabditis elegans)
shrb [cytosol]
(Drosophila melanogaster)
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9BSW7 SYT17
0.8
6
UniProt:Q8WUM4 PDCD6IP
1
PDCD6IP [cytosol]
(R-HSA-917717)
0.683
3
UniProt:O95630 STAMBP
1
STAMBP [cytosol]
(R-HSA-5693063)
0.553
2
UniProt:Q99618 CDCA3
0.527
2
UniProt:Q9UIW0 VAX2
0.527
2
UniProt:Q8N6S5 AR6P6
0.527
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text