Reactome | K63polyUb-DDX58 [cytosol]

K63polyUb-DDX58 [cytosol]

Stable Identifier

R-HSA-918191

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

K63polyUb-RIG-I, K63 polyuniquitinated RIG-I, Ub-RIG-I

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Locations in the PathwayBrowser for interactor UniProt:Q8TAT6 NPLOC4

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Literature References

PubMed ID	Title	Journal	Year
17392790	TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity Takeuchi, O, Gack, MU, Joo, CH, Inoue, S, Akira, S, Shin, YC, Liang, C, Jung, JU, Sun, L, Urano, T, Chen, Z	Nature	2007
15208624	The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses Taira, K, Shinobu, N, Yoneyama, M, Fujita, T, Miyagishi, M, Kikuchi, M, Imaizumi, T, Natsukawa, T	Nat Immunol	2004
19484123	REUL is a novel E3 ubiquitin ligase and stimulator of retinoic-acid-inducible gene-I Chen, DY, Gao, D, Yang, YK, Jiang, ZF, Diao, FC, Zhou, X, Zhai, ZH, Wang, RP, Li, MD	PLoS One	2009

External Reference Information

External Reference

UniProt:O95786 RIGI

Gene Names

RIGI, DDX58

Chain

chain:1-925

Reference Genes

COSMIC (genes):DDX58 RIGI

dbSNP Gene:23586 RIGI

ENSEMBL:ENSG00000107201 DDX58

Participates

as an input of

CYLD mediated deubiquitination of DDX58 (RIG-I) (Homo sapiens)

as a component of

2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)

Other forms of this molecule

PolyUb-DDX58 [cytosol]

K48polyUb-DDX58 [cytosol]

DDX58 [cytosol]

Inferred To

Homologues of K63polyUb-DDX58 [cytosol] (Saccharomyces cerevisiae)

helF [cytosol] (Dictyostelium discoideum)

rigi [cytosol] (Xenopus tropicalis)

K63polyUb-DDX58 [cytosol] (Bos taurus)

K63polyUb-DDX58 [cytosol] (Caenorhabditis elegans)

K63polyUb-DDX58 [cytosol] (Mus musculus)

K63polyUb-DDX58 [cytosol] (Plasmodium falciparum)

K63polyUb-DDX58 [cytosol] (Rattus norvegicus)

K63polyUb-DDX58 [cytosol] (Saccharomyces cerevisiae)

K63polyUb-DDX58 [cytosol] (Sus scrofa)

Modified Residues

Name

ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 154

Coordinate

154

Modification

K63polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Name

ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 164

Coordinate

164

Modification

K63polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Name

ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 172

Coordinate

172

Modification

K63polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Interactors (25)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q7Z434 MAVS	2	MAVS [mitochondrial outer membrane] (R-HSA-913730) K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463)	0.956	19
UniProt:Q14258 TRIM25	2	TRIM25 [nucleoplasm] (R-HSA-5653667) TRIM25 [cytosol] (R-HSA-918186)	0.845	9
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.786	15
UniProt:P0DTD1-PRO_0000449623 REP			0.72	6
UniProt:O75569 PRKRA	2	PRKRA [cytosol] (R-HSA-2399897) p-S246,S287-PRKRA [cytosol] (R-HSA-9834791)	0.688	5
ChEBI:84491 POLY(I			0.656	3
UniProt:O95786 RIGI	4	PolyUb-DDX58 [cytosol] (R-HSA-6782770) K48polyUb-DDX58 [cytosol] (R-HSA-3080568) K63polyUb-DDX58 [cytosol] (R-HSA-918191) DDX58 [cytosol] (R-HSA-168917)	0.656	3
IntAct:EBI-26608251 NC			0.65	9
UniProt:Q8TAT6 NPLOC4	2	NPLOC4 [nucleoplasm] (R-HSA-5654987) NPLOC4 [cytosol] (R-HSA-9755492)	0.619	6
UniProt:Q96EQ8 RNF125	2	RNF125 [cytosol] (R-HSA-918184) K48polyUb-RNF125 [cytosol] (R-HSA-3080560)	0.591	4
UniProt:A0A0B5AC19 NSS			0.59	5
UniProt:P59596 M	10	M [plasma membrane] (R-COV-9731038) M [Golgi membrane] (R-COV-9683651) N-glycan M [endoplasmic reticulum membrane] (R-COV-9683588) nascent M [endoplasmic reticulum lumen] (R-COV-9683586) N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9684206) M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9684213) M [endocytic vesicle membrane] (R-COV-9686687) N-glycan M [endocytic vesicle membrane] (R-COV-9686698) M [virion membrane] (R-COV-9678151) N-glycan M [virion membrane] (R-COV-9685474)	0.589	4
UniProt:Q7Z2W4-2 ZC3HAV1			0.589	4
IntAct:EBI-26977473 3PRNA			0.558	2
UniProt:Q920D5 CASPC			0.557	4
UniProt:Q6IUF9 Z			0.544	3
UniProt:Q6IVU5 Z			0.544	3
IntAct:EBI-26977583 3’UTR-SENSE			0.544	4
UniProt:Q6UY71 Z			0.544	3
UniProt:Q7Z2W4 ZC3HAV1	2	ZC3HAV1(2-624)-BRAF(439-766) fusion [cytosol] (R-HSA-6802506) ZC3HAV1(2-624)-p-BRAF(439-766) fusion [cytosol] (R-HSA-6802557)	0.524	3
UniProt:P04487 RNB			0.524	4
UniProt:Q9NQC7 CYLD	3	CYLD [cytosol] (R-HSA-741420) p-S418-CYLD [cytosol] (R-HSA-5212667) K48polyUb-K338, K530-CYLD [cytosol] (R-HSA-9818664)	0.524	2
UniProt:Q96S55 WRIP1			0.499	2
UniProt:P0DTD2 9b	3	p-S53-9b [cytosol] (R-COV-9758478) 9b [cytosol] (R-COV-9694649) 9b [mitochondrial outer membrane] (R-COV-9709803)	0.463	2
UniProt:P0DTC5 M	10	M [plasma membrane] (R-COV-9755780) N-glycan M [virion membrane] (R-COV-9694385) M [virion membrane] (R-COV-9694320) M [endocytic vesicle membrane] (R-COV-9694563) N-glycan M [endocytic vesicle membrane] (R-COV-9694738) M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694439) N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694446) M [endoplasmic reticulum membrane] (R-COV-9767620) nascent M [endoplasmic reticulum lumen] (R-COV-9694279) N-glycan M [endoplasmic reticulum membrane] (R-COV-9694684)	0.463	3

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