Reactome | K63polyUb-DDX58 [cytosol]

K63polyUb-DDX58 [cytosol]

Stable Identifier

R-HSA-918191

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

K63polyUb-RIG-I, K63 polyuniquitinated RIG-I, Ub-RIG-I

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Locations in the PathwayBrowser for interactor UniProt:Q8TAT6 NPLOC4

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Literature References

PubMed ID	Title	Journal	Year
17392790	TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity Gack, MU, Shin, YC, Joo, CH, Urano, T, Liang, C, Sun, L, Takeuchi, O, Akira, S, Chen, Z, Inoue, S, Jung, JU	Nature	2007
15208624	The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses Yoneyama, M, Kikuchi, M, Natsukawa, T, Shinobu, N, Imaizumi, T, Miyagishi, M, Taira, K, Fujita, T	Nat Immunol	2004
19484123	REUL is a novel E3 ubiquitin ligase and stimulator of retinoic-acid-inducible gene-I Gao, D, Yang, YK, Wang, RP, Zhou, X, Diao, FC, Li, MD, Zhai, ZH, Jiang, ZF, Chen, DY	PLoS One	2009

External Reference Information

External Reference

UniProt:O95786 RIGI

Gene Names

RIGI, DDX58

Chain

chain:1-925

Reference Genes

BioGPS Gene:23586 RIGI

COSMIC (genes):DDX58 RIGI

CTD Gene:23586 RIGI

dbSNP Gene:23586 RIGI

ENSEMBL:ENSG00000107201 RIGI

HGNC:19102 RIGI

KEGG:hsa:23586 RIGI

Monarch:23586 RIGI

NCBI Gene:23586 RIGI

OMIM:609631 RIGI

UCSC:O95786 RIGI

Reference Transcript

RefSeq:NM_014314.3 RIGI

Participates

as an input of

CYLD mediated deubiquitination of DDX58 (RIG-I) (Homo sapiens)

as a component of

2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)

Other forms of this molecule

DDX58 [cytosol]

K48polyUb-DDX58 [cytosol]

PolyUb-DDX58 [cytosol]

Inferred To

drh-3 [cytosol] (Caenorhabditis elegans)

helF [cytosol] (Dictyostelium discoideum)

rigi [cytosol] (Xenopus tropicalis)

Rigi [cytosol] (Mus musculus)

RIGI [cytosol] (Bos taurus)

RIGI [cytosol] (Sus scrofa)

Rig1 [cytosol] (Rattus norvegicus)

Modified Residues

Name

ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 154

Coordinate

154

Modification

K63polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Name

ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 164

Coordinate

164

Modification

K63polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Name

ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 172

Coordinate

172

Modification

K63polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_055129.2

Guide to Pharmacology - Targets

2920

ENSEMBL

ENSP00000369197, ENST00000379883, ENSG00000107201, ENST00000379868, ENSP00000369213

OpenTargets

ENSG00000107201

HPA

ENSG00000107201-RIGI

GeneCards

RIGI

PRO

O95786

Pharos - Targets

O95786

GlyGen

O95786

Orphanet

RIGI

HMDB Protein

HMDBP11688

PDB

7TNZ, 3ZD6, 7BAH, 8SCZ, 8DVS, 6KYV, 5F98, 8DVR, 3ZD7, 7TO2, 4NQK, 8DVU, 6GPG, 4P4H, 7TNY, 2LWE, 3NCU, 4BPB, 3LRR, 5E3H, 2LWD, 2QFB, 5F9F, 2QFD, 8SD0, 8G7U, 3OG8, 2RMJ, 4AY2, 8G7T, 7TO1, 4ON9, 7TNX, 2YKG, 8G7V, 7BAI, 7JL1, 7TO0, 3LRN, 7MK1, 7JL3, 5F9H

Interactors (25)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q7Z434 MAVS	2	MAVS [mitochondrial outer membrane] (R-HSA-913730) K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463)	0.956	19
UniProt:Q14258 TRIM25	2	TRIM25 [nucleoplasm] (R-HSA-5653667) TRIM25 [cytosol] (R-HSA-918186)	0.845	9
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.786	15
UniProt:P0DTD1-PRO_0000449623 REP			0.72	6
UniProt:O75569 PRKRA	2	p-S246,S287-PRKRA [cytosol] (R-HSA-9834791) PRKRA [cytosol] (R-HSA-2399897)	0.688	5
UniProt:O95786 RIGI	4	DDX58 [cytosol] (R-HSA-168917) K63polyUb-DDX58 [cytosol] (R-HSA-918191) K48polyUb-DDX58 [cytosol] (R-HSA-3080568) PolyUb-DDX58 [cytosol] (R-HSA-6782770)	0.656	3
ChEBI:84491 POLY(I			0.656	3
IntAct:EBI-26608251 NC			0.65	9
UniProt:Q8TAT6 NPLOC4	2	NPLOC4 [nucleoplasm] (R-HSA-5654987) NPLOC4 [cytosol] (R-HSA-9755492)	0.619	6
UniProt:Q96EQ8 RNF125	2	RNF125 [cytosol] (R-HSA-918184) K48polyUb-RNF125 [cytosol] (R-HSA-3080560)	0.591	4
UniProt:A0A0B5AC19 NSS			0.59	5
UniProt:Q7Z2W4-2 ZC3HAV1			0.589	4
UniProt:P59596 M	10	M [plasma membrane] (R-COV-9731038) M [Golgi membrane] (R-COV-9683651) N-glycan M [endoplasmic reticulum membrane] (R-COV-9683588) nascent M [endoplasmic reticulum lumen] (R-COV-9683586) N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9684206) M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9684213) M [endocytic vesicle membrane] (R-COV-9686687) N-glycan M [endocytic vesicle membrane] (R-COV-9686698) M [virion membrane] (R-COV-9678151) N-glycan M [virion membrane] (R-COV-9685474)	0.589	4
IntAct:EBI-26977473 3PRNA			0.558	2
UniProt:Q920D5 CASPC			0.557	4
UniProt:Q6UY71 Z			0.544	3
IntAct:EBI-26977583 3’UTR-SENSE			0.544	4
UniProt:Q6IVU5 Z			0.544	3
UniProt:Q6IUF9 Z			0.544	3
UniProt:P04487 RNB			0.524	4
UniProt:Q9NQC7 CYLD	3	CYLD [cytosol] (R-HSA-741420) p-S418-CYLD [cytosol] (R-HSA-5212667) K48polyUb-K338, K530-CYLD [cytosol] (R-HSA-9818664)	0.524	2
UniProt:Q7Z2W4 ZC3HAV1	2	ZC3HAV1(2-624)-BRAF(439-766) fusion [cytosol] (R-HSA-6802506) ZC3HAV1(2-624)-p-BRAF(439-766) fusion [cytosol] (R-HSA-6802557)	0.524	3
UniProt:Q96S55 WRIP1			0.499	2
UniProt:P0DTD2 9b	3	p-S53-9b [cytosol] (R-COV-9758478) 9b [cytosol] (R-COV-9694649) 9b [mitochondrial outer membrane] (R-COV-9709803)	0.463	2
UniProt:P0DTC5 M	10	M [plasma membrane] (R-COV-9755780) N-glycan M [virion membrane] (R-COV-9694385) M [virion membrane] (R-COV-9694320) M [endocytic vesicle membrane] (R-COV-9694563) N-glycan M [endocytic vesicle membrane] (R-COV-9694738) M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694439) N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694446) M [endoplasmic reticulum membrane] (R-COV-9767620) nascent M [endoplasmic reticulum lumen] (R-COV-9694279) N-glycan M [endoplasmic reticulum membrane] (R-COV-9694684)	0.463	3

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