Phosphorylated STAT5 is released

Stable Identifier
R-HSA-919404
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Deletion mutants have demonstrated that STAT dimerization can occur independently of the binding of 2 STAT molecules by a dimeric receptor. Although this does not exclude the possibility that STATs may dimerize while still associated with the receptor complex, dimerization is believe to occur following the release of phosphorylated monomers (e.g. Turkson & Jove 2000).
Literature References
PubMed ID Title Journal Year
9030599 A single STAT recruitment module in a chimeric cytokine receptor complex is sufficient for STAT activation

Heinrich, PC, Janzen, C, Horn, F, Schmitz-Van de Leur, H, Behrmann, I, Graeve, L, Heesel, B, Hermanns, H, Tavernier, J, Gerhartz, C

J Biol Chem 1997
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