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RGS20 [plasma membrane]
Stable Identifier
R-HSA-921136
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Regulator of G-protein signaling 20, RGS20_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Active G alpha (i)–i1/i2/i3 binds RGS proteins (Homo sapiens)
G alpha (i):GTP:RGS [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS20 [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS20 [plasma membrane] (Homo sapiens)
G alpha (i) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)
RGS proteins active for G alpha (i) [plasma membrane] (Homo sapiens)
RGS20 [plasma membrane] (Homo sapiens)
G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Homo sapiens)
G alpha (i):GDP:RGS [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS20 [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS20 [plasma membrane] (Homo sapiens)
G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Homo sapiens)
G alpha (i):GDP:RGS [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS20 [plasma membrane] (Homo sapiens)
G alpha (i):GTP:RGS [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS20 [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS20 [plasma membrane] (Homo sapiens)
G alpha (z) signalling events (Homo sapiens)
Active G alpha (z) binds RGS proteins (Homo sapiens)
G alpha (z):GTP:RGS16,17,20 [plasma membrane] (Homo sapiens)
RGS16,17,20 [plasma membrane] (Homo sapiens)
RGS20 [plasma membrane] (Homo sapiens)
RGS16,17,20 [plasma membrane] (Homo sapiens)
RGS20 [plasma membrane] (Homo sapiens)
G alpha (z) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)
RGS proteins active for G alpha (z) [plasma membrane] (Homo sapiens)
RGS20 [plasma membrane] (Homo sapiens)
G alpha (z) in G alpha (z):RGS complex is inactivated (Homo sapiens)
G alpha (z):GDP:RGS16,17,20 [plasma membrane] (Homo sapiens)
RGS16,17,20 [plasma membrane] (Homo sapiens)
RGS20 [plasma membrane] (Homo sapiens)
G alpha (z):GTP:RGS16,17,20 [plasma membrane] (Homo sapiens)
RGS16,17,20 [plasma membrane] (Homo sapiens)
RGS20 [plasma membrane] (Homo sapiens)
RGS16,17,20 [plasma membrane] (Homo sapiens)
RGS20 [plasma membrane] (Homo sapiens)
G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Homo sapiens)
G alpha (z):GDP:RGS16,17,20 [plasma membrane] (Homo sapiens)
RGS16,17,20 [plasma membrane] (Homo sapiens)
RGS20 [plasma membrane] (Homo sapiens)
RGS16,17,20 [plasma membrane] (Homo sapiens)
RGS20 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O76081 RGS20
Gene Names
RGS20, RGSZ1, ZGAP1
Chain
chain:1-388
Reference Genes
BioGPS Gene:8601 RGS20
COSMIC (genes):RGS20 RGS20
CTD Gene:8601 RGS20
dbSNP Gene:8601 RGS20
ENSEMBL:ENSG00000147509 RGS20
HGNC:14600 RGS20
KEGG:hsa:8601 RGS20
Monarch:8601 RGS20
NCBI Gene:8601 RGS20
OMIM:607193 RGS20
UCSC:O76081 RGS20
Reference Transcript
RefSeq:NM_170587.3 RGS20
RefSeq:NM_001286675.1 RGS20
RefSeq:NM_001286673.1 RGS20
RefSeq:NM_003702.4 RGS20
RefSeq:XM_011517622.2 RGS20
RefSeq:NM_001286674.1 RGS20
Participates
as a member of
RGS16,17,20 [plasma membrane] (Homo sapiens)
RGS proteins active for G alpha (z) [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS proteins active for G alpha (i) [plasma membrane] (Homo sapiens)
Inferred To
Homologues of RGS20 [plasma membrane]
(Dictyostelium discoideum)
Homologues of RGS20 [plasma membrane]
(Saccharomyces cerevisiae)
rgs20 [plasma membrane]
(Xenopus tropicalis)
SST2 [plasma membrane]
(Saccharomyces cerevisiae)
Rgs20 [plasma membrane]
(Mus musculus)
Rgs20 [plasma membrane]
(Rattus norvegicus)
rgs-2 [plasma membrane]
(Caenorhabditis elegans)
Dhit [plasma membrane]
(Drosophila melanogaster)
RGS2 [plasma membrane]
(Saccharomyces cerevisiae)
rgs1 [plasma membrane]
(Schizosaccharomyces pombe)
RGS20 [plasma membrane]
(Bos taurus)
RGS20 [plasma membrane]
(Canis familiaris)
RGS20 [plasma membrane]
(Dictyostelium discoideum)
RGS20 [plasma membrane]
(Gallus gallus)
RGS20 [plasma membrane]
(Sus scrofa)
Cross References
Guide to Pharmacology - Targets
2803
ENSEMBL
ENSP00000297313
,
ENSG00000147509
,
ENSP00000276500
,
ENST00000276500
,
ENST00000344277
,
ENST00000297313
,
ENSP00000344630
OpenTargets
ENSG00000147509
GeneCards
RGS20
HPA
ENSG00000147509-RGS20
PRO
O76081
Pharos - Targets
O76081
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O76003 GLRX3
1
GLRX3 [cytosol]
(R-HSA-5691202)
0.806
7
UniProt:P49639 HOXA1
1
HOXA1 [nucleoplasm]
(R-HSA-5617464)
0.666
5
UniProt:P09022 Hoxa1
1
Hoxa1 [nucleoplasm]
(R-MMU-5617924)
0.57
3
UniProt:P40222 TXLNA
1
TXLNA [cytosol]
(R-HSA-449124)
0.564
2
UniProt:Q9NQS3 NECTIN3
1
PVRL3 [plasma membrane]
(R-HSA-449762)
0.556
3
UniProt:P10809 HSPD1
6
HSPD1(1-26) [mitochondrial matrix]
(R-HSA-8986171)
HSPD1(1-573) [mitochondrial inner membrane]
(R-HSA-1299442)
HSPD1 [mitochondrial inner membrane]
(R-HSA-1299455)
HSPD1(1-573) [mitochondrial intermembrane space]
(R-HSA-1267963)
HSPD1(1-573) [cytosol]
(R-HSA-1267989)
HSPD1 [mitochondrial matrix]
(R-HSA-1299448)
0.556
3
UniProt:P48023 FASLG
1
FASLG(1-281) [extracellular region]
(R-HSA-66212)
0.556
3
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