Reactome | UPF3A [cytosol]

UPF3A [cytosol]

Stable Identifier

R-HSA-927801

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Regulator of nonsense transcripts 3A, REN3A_HUMAN

Locations in the PathwayBrowser

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Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - Signaling by ROBO receptors (Homo sapiens)
      - Regulation of expression of SLITs and ROBOs (Homo sapiens)
        
        Translation of ROBO3.2 mRNA initiates NMD (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        UPF3 [cytosol] (Homo sapiens)
        
        UPF3A [cytosol] (Homo sapiens)
        
        Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        UPF3 [cytosol] (Homo sapiens)
        
        UPF3A [cytosol] (Homo sapiens)
        
        Translation of ROBO3.2 mRNA is negatively regulated by NMD (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        UPF3 [cytosol] (Homo sapiens)
        
        UPF3A [cytosol] (Homo sapiens)
        
        Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        UPF3 [cytosol] (Homo sapiens)
        
        UPF3A [cytosol] (Homo sapiens)

Metabolism of RNA (Homo sapiens)

- Nonsense-Mediated Decay (NMD) (Homo sapiens)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        UPF3 [cytosol] (Homo sapiens)
        
        UPF3A [cytosol] (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        UPF3 [cytosol] (Homo sapiens)
        
        UPF3A [cytosol] (Homo sapiens)
    - SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        UPF3 [cytosol] (Homo sapiens)
        
        UPF3A [cytosol] (Homo sapiens)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        UPF3 [cytosol] (Homo sapiens)
        
        UPF3A [cytosol] (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        UPF3 [cytosol] (Homo sapiens)
        
        UPF3A [cytosol] (Homo sapiens)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        UPF3 [cytosol] (Homo sapiens)
        
        UPF3A [cytosol] (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        UPF3 [cytosol] (Homo sapiens)
        
        UPF3A [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9H1J1 UPF3A

Gene Names

UPF3A, RENT3A, UPF3

Chain

chain:1-476

Reference Genes

BioGPS Gene:65110 UPF3A

COSMIC (genes):UPF3A UPF3A

CTD Gene:65110 UPF3A

dbSNP Gene:65110 UPF3A

ENSEMBL:ENSG00000169062 UPF3A

HGNC:20332 UPF3A

KEGG:hsa:65110 UPF3A

Monarch:65110 UPF3A

NCBI Gene:65110 UPF3A

OMIM:605530 UPF3A

UCSC:Q9H1J1 UPF3A

Reference Transcript

Participates

as a member of

UPF3 [cytosol] (Homo sapiens)

Inferred To

upf3 [cytosol] (Schizosaccharomyces pombe)

UPF3 [cytosol] (Saccharomyces cerevisiae)

Upf3 [cytosol] (Drosophila melanogaster)

UPF3A [cytosol] (Canis familiaris)

UPF3A [cytosol] (Dictyostelium discoideum)

UPF3A [cytosol] (Sus scrofa)

smg-4 [cytosol] (Caenorhabditis elegans)

Upf3a [cytosol] (Mus musculus)

Upf3a [cytosol] (Rattus norvegicus)

upf3a [cytosol] (Danio rerio)

upf3a [cytosol] (Xenopus tropicalis)

Cross References

ENSEMBL

ENSP00000329592, ENSP00000364448, ENST00000375299, ENSG00000169062, ENST00000351487

OpenTargets

ENSG00000169062

GeneCards

UPF3A

HPA

ENSG00000169062-UPF3A

PRO

Q9H1J1

Pharos - Targets

Q9H1J1

GlyGen

Q9H1J1

PDB

7QG6, 2L08

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92900 UPF1	2	UPF1 [cytosol] (R-HSA-927734) p-4S-UPF1 [cytosol] (R-HSA-927856)	0.564	4
UniProt:Q9UBU9 NXF1	2	NXF1 [nucleoplasm] (R-HSA-111690) NXF1 [cytosol] (R-HSA-156481)	0.527	2
UniProt:Q86V81 ALYREF	2	ALYREF [cytosol] (R-HSA-158482) ALYREF [nucleoplasm] (R-HSA-156649)	0.527	2