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p-4S-UPF1 [cytosol]
Stable Identifier
R-HSA-927856
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
UPF1 Phosphorylated at Serines 1084, 1089,1107, 1127, Regulator of nonsense transcripts 1, RENT1_HUMAN, UPF1
Locations in the PathwayBrowser for interactor UniProt:P03496%20NS
Expand all
Metabolism of RNA (Homo sapiens)
Nonsense-Mediated Decay (NMD) (Homo sapiens)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Homo sapiens)
p-4S-UPF1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q92900 UPF1
Gene Names
UPF1, KIAA0221, RENT1
Chain
chain:1-1129
Reference Genes
BioGPS Gene:5976 UPF1
COSMIC (genes):UPF1 UPF1
CTD Gene:5976 UPF1
dbSNP Gene:5976 UPF1
ENSEMBL:ENSG00000005007 UPF1
ENSEMBL_homo_sapiens_GENE:ENSG00000005007.14 UPF1
HGNC:9962 UPF1
KEGG Gene (Homo sapiens):5976 UPF1
Monarch:5976 UPF1
NCBI Gene:5976 UPF1
OMIM:601430 UPF1
UCSC:Q92900 UPF1
Reference Transcript
RefSeq:NM_001297549.1 UPF1
RefSeq:NM_002911.3 UPF1
Other Identifiers
11717322_a_at
11754616_a_at
11754617_s_at
16859874
208947_PM_s_at
208947_s_at
211168_PM_s_at
211168_s_at
3825384
3825385
3825386
3825393
3825394
3825395
3825396
3825398
3825400
3825401
3825402
3825404
3825405
3825406
3825408
3825409
3825411
3825412
3825414
3825416
3825417
3825419
3825420
3825421
3825423
3825424
3825426
3825427
3825428
39404_s_at
5976
8027074
A_24_P194154
D86988_at
GE62804
GO:0000166
GO:0000184
GO:0000781
GO:0000785
GO:0000932
GO:0000956
GO:0003677
GO:0003682
GO:0003723
GO:0003724
GO:0003824
GO:0004386
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0006260
GO:0006281
GO:0006406
GO:0006449
GO:0006913
GO:0008270
GO:0010468
GO:0016071
GO:0016787
GO:0016887
GO:0032200
GO:0032201
GO:0032204
GO:0032508
GO:0035145
GO:0036121
GO:0042162
GO:0043226
GO:0044530
GO:0044770
GO:0044877
GO:0046872
GO:0048471
GO:0061014
GO:0061158
GO:0071044
GO:0071222
GO:0071347
GO:0140097
GO:0140098
GO:0140657
GO:1905746
HMNXSV003007509
ILMN_1688011
PH_hs_0024447
TC19000365.hg
U65533_s_at
g1633577_3p_a_at
g1944406_3p_a_at
Participates
as a component of
SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
mRNA Cleaved by SMG6 [cytosol] (Homo sapiens)
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
This entity regulates
Positively
Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex
(Homo sapiens)
Other forms of this molecule
UPF1 [cytosol]
Inferred To
phospho-Upf1 [cytosol]
(Rattus norvegicus)
phospho-p-4S-UPF1 [cytosol]
(Caenorhabditis elegans)
phospho-p-4S-UPF1 [cytosol]
(Danio rerio)
phospho-p-4S-UPF1 [cytosol]
(Dictyostelium discoideum)
phospho-p-4S-UPF1 [cytosol]
(Drosophila melanogaster)
phospho-p-4S-UPF1 [cytosol]
(Gallus gallus)
phospho-p-4S-UPF1 [cytosol]
(Mus musculus)
phospho-p-4S-UPF1 [cytosol]
(Plasmodium falciparum)
phospho-p-4S-UPF1 [cytosol]
(Saccharomyces cerevisiae)
phospho-p-4S-UPF1 [cytosol]
(Schizosaccharomyces pombe)
phospho-upf1 [cytosol]
(Xenopus tropicalis)
phospho-UPF1 [cytosol]
(Bos taurus)
phospho-UPF1 [cytosol]
(Canis familiaris)
phospho-UPF1 [cytosol]
(Sus scrofa)
Modified Residues
Name
O-phospho-L-serine at 1089
Coordinate
1089
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1107
Coordinate
1107
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1084
Coordinate
1084
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1127
Coordinate
1127
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001284478.1
,
NP_002902.2
OpenTargets
ENSG00000005007
HPA
ENSG00000005007-UPF1
GeneCards
Q92900
Ensembl
ENSP00000470142
,
ENST00000599848
,
ENSG00000005007
,
ENST00000262803
,
ENSP00000262803
PRO
Q92900
Pharos - Targets
Q92900
PDB
6EJ5
,
2GK7
,
2WJY
,
2XZP
,
6Z3R
,
2GJK
,
2GK6
,
2XZO
,
2IYK
,
2WJV
Interactors (26)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9HAU5 UPF2
1
UPF2 [cytosol]
(R-HSA-927799)
0.953
29
UniProt:Q9BZI7 UPF3B
2
UPF3B [nucleoplasm]
(R-HSA-156776)
UPF3B [cytosol]
(R-HSA-159258)
0.848
10
UniProt:Q9NPI6 DCP1A
1
DCP1A [cytosol]
(R-HSA-430043)
0.783
13
UniProt:Q96Q15 SMG1
1
SMG1 [cytosol]
(R-HSA-927760)
0.758
7
UniProt:O95793 STAU1
0.714
5
UniProt:O15234 CASC3
2
CASC3 [nucleoplasm]
(R-HSA-8849148)
CASC3 [cytosol]
(R-HSA-927807)
0.698
5
UniProt:Q09161 NCBP1
2
NCBP1 [nucleoplasm]
(R-HSA-51469)
NCBP1 [cytosol]
(R-HSA-162459)
0.69
9
UniProt:Q9Y5S9 RBM8A
2
RBM8A [cytosol]
(R-HSA-162462)
RBM8A [nucleoplasm]
(R-HSA-156659)
0.643
3
UniProt:P0DTC9 N
13
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane]
(R-COV-9729325)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus]
(R-COV-9729339)
N [plasma membrane]
(R-COV-9694356)
SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol]
(R-COV-9756489)
N [cytosol]
(R-COV-9694300)
p-S188,206-N [cytosol]
(R-COV-9729324)
p-8S-N [cytosol]
(R-COV-9729335)
p-8S,2T-N [cytosol]
(R-COV-9729277)
p-11S,2T-N [cytosol]
(R-COV-9729264)
p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729308)
ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729275)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9729341)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729340)
0.643
3
UniProt:Q8IU60 DCP2
1
DCP2 [cytosol]
(R-HSA-429937)
0.641
3
UniProt:Q9NPJ4 PNRC2
1
PNRC2 [cytosol]
(R-HSA-8879146)
0.616
9
UniProt:Q9UN81 LORF1
0.576
6
UniProt:Q8IYD1 GSPT2
1
GSPT2 [cytosol]
(R-HSA-143379)
0.576
3
UniProt:Q9H1J1 UPF3A
1
UPF3A [cytosol]
(R-HSA-927801)
0.564
4
UniProt:P52298 NCBP2
2
NCBP2 [nucleoplasm]
(R-HSA-51463)
NCBP2 [cytosol]
(R-HSA-162458)
0.527
3
UniProt:P11940 PABPC1
1
PABPC1 [cytosol]
(R-HSA-156803)
0.527
3
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.527
3
UniProt:P03496 NS
2
NS1 [nucleoplasm]
(R-FLU-169113)
NS1 [cytosol]
(R-FLU-169118)
0.527
2
UniProt:P55265 ADAR
2
ADAR1 [cytosol]
(R-HSA-9835955)
ADAR [nucleoplasm]
(R-HSA-53939)
0.524
3
UniProt:Q96AP0 ACD
1
ACD [nucleoplasm]
(R-HSA-174889)
0.524
3
UniProt:O14746 TERT
1
TERT [nucleoplasm]
(R-HSA-163076)
0.524
3
UniProt:Q92540 SMG7
1
SMG7 [cytosol]
(R-HSA-927838)
0.499
3
UniProt:Q14493 SLBP
2
SLBP [nucleoplasm]
(R-HSA-64547)
SLBP [cytosol]
(R-HSA-141613)
0.499
3
UniProt:Q9BZI7-2 UPF3B
0.488
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
10
UniProt:P06730 EIF4E
1
EIF4E [cytosol]
(R-HSA-72578)
0.462
3
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