Reactome | TANK [cytosol]

TANK [cytosol]

Stable Identifier

R-HSA-933407

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

TRAF family member-associated NF-kappa-B activator, TANK_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q8NFZ5 TNIP2

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External Reference Information

External Reference

UniProt:Q92844 TANK

Gene Names

TANK, ITRAF, TRAF2

Chain

chain:1-425

Reference Genes

COSMIC (genes):TANK TANK

COSMIC (genes):TRAF2 TANK

dbSNP Gene:10010 TANK

ENSEMBL:ENSG00000136560 TANK

Participates

as an input of

as a component of

Other forms of this molecule

K63polyUb-TANK [cytosol]

Inferred To

Tank [cytosol] (Rattus norvegicus)

TANK [cytosol] (Bos taurus)

TANK [cytosol] (Canis familiaris)

TANK [cytosol] (Gallus gallus)

TANK [cytosol] (Mus musculus)

TANK [cytosol] (Sus scrofa)

Interactors (20)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UHD2 TBK1	5	p-S172-TBK1 [cytosol] (R-HSA-168379) TBK1 [cytosol] (R-HSA-166267) K63polyUb-K30,K401-TBK1 [cytosol] (R-HSA-9730430) p-TBK1 [cytosol] (R-HSA-9008705) pS-172,K48polyUb-TBK1 [cytosol] (R-HSA-3249397)	0.931	15
UniProt:Q13114 TRAF3	4	K63polyUb-TRAF3 [cytosol] (R-HSA-936402) TRAF3 [cytosol] (R-HSA-914241) K48polyUb-TRAF3 [cytosol] (R-HSA-936556) TRAF3 R118W [cytosol] (R-HSA-5602321)	0.87	8
UniProt:Q12933 TRAF2	5	TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199)	0.854	10
UniProt:Q14164 IKBKE	5	IKBKE [cytosol] (R-HSA-450225) p-S172-IKBKE [cytosol] (R-HSA-450278) K63polyUb-K30,K401-IKBKE [cytosol] (R-HSA-9730436) p-S172-IKBKE [nucleoplasm] (R-HSA-4755521) monoSUMO1-K231-p-S172-IKBKE [nucleoplasm] (R-HSA-4755535)	0.829	5
UniProt:Q13490 BIRC2	5	BIRC2 [cytosol] (R-HSA-50847) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2(373-618) [cytosol] (R-HSA-202931) BIRC2(1-372) [cytosol] (R-HSA-202913) K63polyUb-BIRC2 [cytosol] (R-HSA-5668512)	0.725	5
UniProt:P53350 PLK1	4	PLK1 [cytosol] (R-HSA-164603) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) p-T210-PLK1 [cytosol] (R-HSA-3000318) PLK1 [nucleoplasm] (R-HSA-156720)	0.674	4
UniProt:Q9Y6K9 IKBKG	12	IKBKG [cytosol] (R-HSA-168108) Ub-285-IKBKG [cytosol] (R-HSA-741397) K63polyUb-IKBKG [cytosol] (R-HSA-202530) IKBKG [nucleoplasm] (R-HSA-4755413) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG D406V [cytosol] (R-HSA-5262943)	0.659	6
UniProt:Q96MT8 CEP63	1	CEP63 [cytosol] (R-HSA-380267)	0.659	4
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.659	5
UniProt:Q92844 TANK	2	K63polyUb-TANK [cytosol] (R-HSA-5362480) TANK [cytosol] (R-HSA-933407)	0.564	3
UniProt:Q05519 SRSF11	1	SRSF11 [nucleoplasm] (R-HSA-72058)	0.556	3
UniProt:Q13625-3 TP53BP2			0.556	3
UniProt:O00463 TRAF5			0.527	2
UniProt:Q8NFZ5 TNIP2	1	TNIP2 [cytosol] (R-HSA-451661)	0.527	3
UniProt:O75936 BBOX1	1	BBOX1 [cytosol] (R-HSA-71104)	0.527	3
UniProt:P17362 PG029			0.524	2
UniProt:Q92574 TSC1	2	TSC1 [cytosol] (R-HSA-5672338) TSC1 [plasma membrane] (R-HSA-165169)	0.508	3
UniProt:P03495 NS1			0.508	2
UniProt:O96018 APBA3	1	APBA3 [cytosol] (R-HSA-6794262)	0.499	2
UniProt:P61956 SUMO2	6	lysyl-G93-SUMOyl-K11-SUMO2 [nucleoplasm] (R-HSA-9761546) UBE2I-G93-SUMO2 [nucleoplasm] (R-HSA-3730625) SUMO2 [nucleoplasm] (R-HSA-2984281) lysyl-G93-SUMO2 [cytosol] (R-HSA-9834803) UBA2-G93-SUMO2 [nucleoplasm] (R-HSA-3730618) SUMO2(1-95) [nucleoplasm] (R-HSA-2990837)	0.499	3

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