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TANK [cytosol]
Stable Identifier
R-HSA-933407
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
TRAF family member-associated NF-kappa-B activator, TANK_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q96MT8%20CEP63
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
TRAF6 mediated IRF7 activation (Homo sapiens)
Recruitment of TANK to TRAF6 (Homo sapiens)
TANK [cytosol] (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
TICAM1-dependent activation of IRF3/IRF7 (Homo sapiens)
TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR3 (Homo sapiens)
TANK [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Homo sapiens)
TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4 (Homo sapiens)
TANK [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q92844 TANK
Gene Names
TANK, ITRAF, TRAF2
Chain
chain:1-425
Reference Genes
BioGPS Gene:10010 TANK
COSMIC (genes):TANK TANK
CTD Gene:10010 TANK
dbSNP Gene:10010 TANK
ENSEMBL:ENSG00000136560 TANK
ENSEMBL_homo_sapiens_GENE:ENSG00000136560.14 TANK
HGNC:11562 TANK
KEGG Gene (Homo sapiens):10010 TANK
Monarch:10010 TANK
NCBI Gene:10010 TANK
OMIM:603893 TANK
UCSC:Q92844 TANK
Reference Transcript
RefSeq:NM_133484.1 TANK
RefSeq:XM_017003097.1 TANK
RefSeq:NM_004180.2 TANK
RefSeq:XM_017003096.1 TANK
RefSeq:NM_001199135.1 TANK
Other Identifiers
10010
11724596_s_at
11752780_a_at
11752781_s_at
11753782_a_at
207616_PM_s_at
207616_s_at
209451_PM_at
209451_at
210458_3p_s_at
210458_PM_s_at
210458_s_at
2512602
2512604
2512621
2512622
2512636
2512637
2512638
2512639
2512649
2512653
2512654
2512659
2512665
2512666
2512667
39742_at
8045933
A_14_P124419
A_23_P154306
A_24_P257108
GE61485
GO:0002376
GO:0003824
GO:0004843
GO:0005515
GO:0005737
GO:0005829
GO:0006974
GO:0007165
GO:0007249
GO:0016787
GO:0023052
GO:0031625
GO:0032481
GO:0032991
GO:0035800
GO:0036211
GO:0043124
GO:0046872
GO:0051607
GO:0060090
GO:0060337
GO:0071347
GO:0071356
GO:0071479
GO:0098542
GO:0098772
GO:0140096
GO:1902554
GO:1903003
GO:2000158
HMNXSV003026850
HMNXSV003041373
HMNXSV003045821
ILMN_1715069
ILMN_1793849
ILMN_2292387
ILMN_2372773
PH_hs_0008774
U59863_at
g13097263_3p_a_at
g13097263_3p_at
g13097263_3p_x_at
g1518017_3p_at
g4759249_3p_a_at
Participates
as an input of
TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR3 (Homo sapiens)
TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4 (Homo sapiens)
Recruitment of TANK to TRAF6 (Homo sapiens)
as a component of
TANK:K63-poly-Ub-TRAF3:TICAM1:viral dsRNA:TLR3 [endosome membrane] (Homo sapiens)
TANK:K63-poly-Ub-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
Other forms of this molecule
K63polyUb-TANK [cytosol]
Inferred To
Tank [cytosol]
(Rattus norvegicus)
TANK [cytosol]
(Bos taurus)
TANK [cytosol]
(Canis familiaris)
TANK [cytosol]
(Gallus gallus)
TANK [cytosol]
(Mus musculus)
TANK [cytosol]
(Sus scrofa)
Cross References
RefSeq
XP_016858586.1
,
NP_597841.1
,
XP_016858585.1
,
NP_001186064.1
,
NP_004171.2
OpenTargets
ENSG00000136560
HPA
ENSG00000136560-TANK
GeneCards
Q92844
Ensembl
ENSP00000385983
,
ENSG00000136560
,
ENSP00000259075
,
ENST00000392749
,
ENST00000403609
,
ENST00000259075
,
ENSP00000376505
PRO
Q92844
Pharos - Targets
Q92844
PDB
1L0A
,
1KZZ
,
5H10
Interactors (17)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UHD2 TBK1
5
pS-172,K48polyUb-TBK1 [cytosol]
(R-HSA-3249397)
p-TBK1 [cytosol]
(R-HSA-9008705)
K63polyUb-K30,K401-TBK1 [cytosol]
(R-HSA-9730430)
p-S172-TBK1 [cytosol]
(R-HSA-168379)
TBK1 [cytosol]
(R-HSA-166267)
0.924
14
UniProt:Q13114 TRAF3
4
TRAF3 R118W [cytosol]
(R-HSA-5602321)
K48polyUb-TRAF3 [cytosol]
(R-HSA-936556)
TRAF3 [cytosol]
(R-HSA-914241)
K63polyUb-TRAF3 [cytosol]
(R-HSA-936402)
0.829
7
UniProt:Q12933 TRAF2
5
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.809
8
UniProt:Q14164 IKBKE
5
monoSUMO1-K231-p-S172-IKBKE [nucleoplasm]
(R-HSA-4755535)
IKBKE [cytosol]
(R-HSA-450225)
p-S172-IKBKE [cytosol]
(R-HSA-450278)
K63polyUb-K30,K401-IKBKE [cytosol]
(R-HSA-9730436)
p-S172-IKBKE [nucleoplasm]
(R-HSA-4755521)
0.779
4
UniProt:Q96MT8 CEP63
1
CEP63 [cytosol]
(R-HSA-380267)
0.659
4
UniProt:Q13490 BIRC2
5
K63polyUb-BIRC2 [cytosol]
(R-HSA-5668512)
BIRC2(1-372) [cytosol]
(R-HSA-202913)
BIRC2(373-618) [cytosol]
(R-HSA-202931)
K48pUb-BIRC2 [cytosol]
(R-HSA-5675479)
BIRC2 [cytosol]
(R-HSA-50847)
0.643
4
UniProt:P53350 PLK1
4
PLK1 [nucleoplasm]
(R-HSA-156720)
p-T210-PLK1 [cytosol]
(R-HSA-3000318)
p-T210-PLK1 [nucleoplasm]
(R-HSA-3002800)
PLK1 [cytosol]
(R-HSA-164603)
0.57
3
UniProt:Q92844 TANK
2
TANK [cytosol]
(R-HSA-933407)
K63polyUb-TANK [cytosol]
(R-HSA-5362480)
0.564
3
UniProt:Q13625-3 TP53BP2
0.556
3
UniProt:Q05519 SRSF11
1
SRSF11 [nucleoplasm]
(R-HSA-72058)
0.556
3
UniProt:Q13077 TRAF1
3
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.547
2
UniProt:Q9Y6K9 IKBKG
12
IKBKG D406V [cytosol]
(R-HSA-5262943)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG *420Wext*447 [cytosol]
(R-HSA-5262978)
monoSUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG [nucleoplasm]
(R-HSA-4755413)
K63polyUb-IKBKG [cytosol]
(R-HSA-202530)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
IKBKG [cytosol]
(R-HSA-168108)
0.547
5
UniProt:P17362 PG029
0.524
2
UniProt:P03495 NS1
0.508
2
UniProt:Q92574 TSC1
2
TSC1 [plasma membrane]
(R-HSA-165169)
TSC1 [cytosol]
(R-HSA-5672338)
0.508
3
UniProt:O96018 APBA3
1
APBA3 [cytosol]
(R-HSA-6794262)
0.499
2
UniProt:P61956 SUMO2
6
lysyl-G93-SUMO2 [cytosol]
(R-HSA-9834803)
SUMO2(1-95) [nucleoplasm]
(R-HSA-2990837)
SUMO2 [nucleoplasm]
(R-HSA-2984281)
UBA2-G93-SUMO2 [nucleoplasm]
(R-HSA-3730618)
UBE2I-G93-SUMO2 [nucleoplasm]
(R-HSA-3730625)
lysyl-G93-SUMOyl-K11-SUMO2 [nucleoplasm]
(R-HSA-9761546)
0.499
3
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