Reactome | CASP8(375-384) [cytosol]

CASP8(375-384) [cytosol]

Stable Identifier

R-HSA-933460

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Casp-8 linker region

Icon

Locations in the PathwayBrowser for interactor UniProt:P51572 BCAP31

Expand all

External Reference Information

External Reference

UniProt:Q14790 CASP8

Gene Names

CASP8, MCH5

Chain

propeptide:1-216, chain:217-374, propeptide:375-384, chain:385-479

Reference Genes

BioGPS Gene:841 CASP8

COSMIC (genes):CASP8 CASP8

CTD Gene:841 CASP8

dbSNP Gene:841 CASP8

ENSEMBL:ENSG00000064012 CASP8

ENSEMBL_homo_sapiens_GENE:ENSG00000064012.24 CASP8

HGNC:1509 CASP8

KEGG Gene (Homo sapiens):841 CASP8

Monarch:841 CASP8

NCBI Gene:841 CASP8

OMIM:601763 CASP8

UCSC:Q14790 CASP8

Reference Transcript

Other Identifiers

11728978_x_at

11741554_x_at

11742324_a_at

11749790_a_at

11754153_x_at

11756062_x_at

1553306_at

207686_PM_s_at

207686_s_at

213373_PM_s_at

213373_s_at

2522729

2522730

2522731

2522732

2522733

2522743

2522744

2522745

2522746

2522747

2522750

2522751

2522752

2522753

2522755

2522756

2522758

2522759

2522764

2522766

2522768

2522769

2522770

2522771

3104672

31491_s_at

33774_at

33775_s_at

8047419

841

A_14_P116206

A_14_P138041

A_23_P209389

A_24_P148499

A_24_P157087

GE60202

GO:0001525

GO:0001817

GO:0002376

GO:0003824

GO:0004197

GO:0005123

GO:0005164

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005741

GO:0005829

GO:0005856

GO:0005886

GO:0006508

GO:0006915

GO:0007507

GO:0008233

GO:0008234

GO:0008625

GO:0010803

GO:0012501

GO:0016485

GO:0016787

GO:0022414

GO:0023052

GO:0030027

GO:0030101

GO:0030154

GO:0030163

GO:0030225

GO:0030335

GO:0031264

GO:0031265

GO:0031625

GO:0032025

GO:0032355

GO:0032496

GO:0032731

GO:0032991

GO:0034612

GO:0035877

GO:0036462

GO:0042110

GO:0042113

GO:0042802

GO:0042981

GO:0043065

GO:0043123

GO:0043124

GO:0043226

GO:0043525

GO:0044297

GO:0044877

GO:0045088

GO:0045471

GO:0045651

GO:0045862

GO:0048856

GO:0048870

GO:0051603

GO:0051604

GO:0051716

GO:0060546

GO:0060715

GO:0070269

GO:0071260

GO:0071407

GO:0097110

GO:0097153

GO:0097190

GO:0097191

GO:0097194

GO:0097199

GO:0097202

GO:0097264

GO:0097342

GO:0098542

GO:0140096

HMNXSV003024001

HMNXSV003029851

Hs.19949.2.S2_3p_a_at

Hs2.381231.5.S1_3p_at

ILMN_1673757

ILMN_1787749

ILMN_1809313

ILMN_2377733

PH_hs_0023198

TC02003767.hg

X98172_at

X98176_at

X98178_s_at

g4502582_3p_a_at

Participates

as an output of

Processing of caspases (Homo sapiens)

Other forms of this molecule

CASP8(1-374) [cytosol]

CASP8(217-374) [mitochondrial outer membrane]

CASP8(385-479) [mitochondrial outer membrane]

CASP8(385-479) [cytosol]

CASP8(217-374) [cytosol]

CASP8(1-216) [cytosol]

CASP8(1-479) [cytosol]

Cross References

RefSeq

NP_001073593.1, XP_006712856.1, NP_203519.1, XP_006712853.1, XP_005246943.1, XP_006712852.1, XP_005246949.1, NP_001219.2, NP_001073594.1, XP_005246946.1, XP_005246947.1, XP_005246944.1, XP_005246948.1, NP_203520.1, NP_203522.1, XP_005246945.1

Guide to Pharmacology - Targets

1624

OpenTargets

ENSG00000064012

ZINC - Substances

CASP8_HUMAN

ZINC target

Q14790

PRO

Q14790

PDB

1QTN, 2Y1L, 7LVJ, 5JQE, 4ZBW, 2FUN, 3H11, 5H33, 6PX9, 4PS1, 2C2Z, 3KJN, 5H31, 1I4E, 7DEE, 4PRZ, 5L08, 6AGW, 3KJQ, 4JJ7, 1F9E, 2K7Z, 7LVM, 1QDU

ZINC - Investigational

CASP8_HUMAN

GeneCards

Q14790

HPA

ENSG00000064012-CASP8

Ensembl

ENSP00000388306, ENST00000440732, ENSP00000512370, ENST00000413726, ENST00000447616, ENST00000392263, ENSP00000512382, ENSP00000351273, ENST00000432109, ENST00000696087, ENSG00000064012, ENSP00000397528, ENST00000444430, ENST00000673742, ENSP00000264275, ENSP00000412523, ENST00000358485, ENSP00000501268, ENSP00000394434, ENSP00000512369, ENST00000323492, ENSP00000325722, ENST00000264275, ENSP00000376087, ENSP00000396869, ENST00000392258, ENST00000696068, ENST00000696067, ENSP00000376091

Pharos - Targets

Q14790

ZINC - Predictions - Purchasable

CASP8_HUMAN

Orphanet

16839

Interactors (32)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13158 FADD	1	FADD [cytosol] (R-HSA-54639)	0.98	47
UniProt:Q13546 RIPK1	20	K48polyUb-RIPK1 [cytosol] (R-HSA-6783308) PolyUb-RIPK1 [cytosol] (R-HSA-6783197) RIPK1 D324N [cytosol] (R-HSA-9693930) RIPK1 D324Y [cytosol] (R-HSA-9693931) RIPK1 D324V [cytosol] (R-HSA-9693927) RIPK1 D324H [cytosol] (R-HSA-9693922) RIPK1 [plasma membrane] (R-HSA-937073) K48polyUb-K571,K604,K627-RIPK1 [cytosol] (R-HSA-9796639) K63,Met1polyUb-p-S25-RIPK1 [cytosol] (R-HSA-9818793) K63,M1polyUb-RIPK1 [cytosol] (R-HSA-9793681) RIPK1(1-324) [cytosol] (R-HSA-5212664) RIPK1(325-671) [cytosol] (R-HSA-5212671) polyUb-K377,K604,K634-RIPK1 [cytosol] (R-HSA-9818391) K63,M1polyUb, p-T189-RIPK1 [cytosol] (R-HSA-9817377) p-S320-RIPK1 [cytosol] (R-HSA-9815498) p-S357-RIPK1 [cytosol] (R-HSA-9819116) p-S166-RIPK1 [cytosol] (R-HSA-5218872) K63polyUb-RIPK1 [cytosol] (R-HSA-937021) RIPK1 [endosome membrane] (R-HSA-450326) RIPK1 [cytosol] (R-HSA-168651)	0.959	30
UniProt:P25445 FAS	1	FAS [plasma membrane] (R-HSA-66248)	0.92	16
UniProt:P50591 TNFSF10	1	TNFSF10 [extracellular region] (R-HSA-66186)	0.919	20
UniProt:O00220 TNFRSF10A	1	TNFRSF10A [plasma membrane] (R-HSA-5633393)	0.817	11
UniProt:O14763 TNFRSF10B	1	TNFRSF10B [plasma membrane] (R-HSA-65505)	0.749	7
UniProt:P48023 FASLG	1	FASLG(1-281) [extracellular region] (R-HSA-66212)	0.744	5
UniProt:O15519 CFLAR	1	CFLAR(1-376) [cytosol] (R-HSA-51925)	0.744	10
UniProt:Q92851 CASP10	4	CASP10(220-415) [cytosol] (R-HSA-933458) CASP10(1-219) [cytosol] (R-HSA-933454) CASP10(416-521) [cytosol] (R-HSA-933455) CASP10(1-521) [cytosol] (R-HSA-933453)	0.734	6
UniProt:Q15628 TRADD	1	TRADD [cytosol] (R-HSA-66376)	0.725	6
UniProt:Q14790 CASP8	8	CASP8(1-374) [cytosol] (R-HSA-3465404) CASP8(217-374) [mitochondrial outer membrane] (R-HSA-351869) CASP8(385-479) [mitochondrial outer membrane] (R-HSA-351828) CASP8(385-479) [cytosol] (R-HSA-76158) CASP8(375-384) [cytosol] (R-HSA-933460) CASP8(217-374) [cytosol] (R-HSA-75975) CASP8(1-216) [cytosol] (R-HSA-933456) CASP8(1-479) [cytosol] (R-HSA-57031)	0.704	4
UniProt:Q9UKL3 CASP8AP2	2	monoSUMO1-K1813-CASP8AP2 [nucleoplasm] (R-HSA-3927850) CASP8AP2 [nucleoplasm] (R-HSA-3927945)	0.704	5
UniProt:P25445-1 FAS			0.669	3
UniProt:Q13618 CUL3	3	G76-NEDD8-K712-CUL3 [cytosol] (R-HSA-8952516) CUL3 [nucleoplasm] (R-HSA-5635033) CUL3 [cytosol] (R-HSA-975979)	0.602	6
UniProt:P51572 BCAP31	6	BCAP31 [lumenal side of endoplasmic reticulum membrane] (R-HSA-985503) BCAP31 [endoplasmic reticulum membrane] (R-HSA-9714333) BCAP31(2-245) [endoplasmic reticulum membrane] (R-HSA-201587) BCAP31(165-237) [endoplasmic reticulum membrane] (R-HSA-351909) BCAP31(2-164) [endoplasmic reticulum membrane] (R-HSA-351826) BCAP31(238-246) [cytosol] (R-HSA-351912)	0.589	3
UniProt:O15519-1 CFLAR	5	M1polyUb-K351,K353-CFLAR(1-480) [cytosol] (R-HSA-9794015) CFLAR(377-480) [cytosol] (R-HSA-3465483) K63polyUb-CFLAR(1-480) [cytosol] (R-HSA-9818805) CFLAR(1-376) [cytosol] (R-HSA-3465408) CFLAR(1-480) [cytosol] (R-HSA-3371356)	0.564	2
UniProt:Q9Y572 RIPK3	8	p-S199,227, K48pUb-363-RIPK3 [cytosol] (R-HSA-9686933) K33polyUb-K197,302,364-RIPK3 [cytosol] (R-HSA-9794180) OGlcNAc-T467-RIPK3 [cytosol] (R-HSA-9687819) RIPK3(329-518) [cytosol] (R-HSA-9686937) RIPK3(1-328) [cytosol] (R-HSA-9686917) RIPK3 [cytosol] (R-HSA-450328) p-S199,227-RIPK3 [cytosol] (R-HSA-5218873) Ub-K55,363-RIPK3 [cytosol] (R-HSA-9688825)	0.564	2
UniProt:Q96AX1 VPS33A	1	VPS33A [endosome membrane] (R-HSA-2197804)	0.556	3
UniProt:P13051-2 UNG			0.556	3
UniProt:Q06787-7 FMR1			0.556	3
UniProt:P53350 PLK1	4	PLK1 [nucleoplasm] (R-HSA-156720) p-T210-PLK1 [cytosol] (R-HSA-3000318) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) PLK1 [cytosol] (R-HSA-164603)	0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.556	3
UniProt:Q9BY76 ANGPTL4	3	ANGPTL4 [extracellular region] (R-HSA-381271) ANGPTL4 [extracellular region] (R-HSA-6784897) ANGPTL4(164-406) [extracellular region] (R-HSA-9762251)	0.547	2
UniProt:Q13490 BIRC2	5	K63polyUb-BIRC2 [cytosol] (R-HSA-5668512) BIRC2(1-372) [cytosol] (R-HSA-202913) BIRC2(373-618) [cytosol] (R-HSA-202931) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2 [cytosol] (R-HSA-50847)	0.527	2
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.527	3
UniProt:O60936 NOL3			0.524	3
UniProt:P29350 PTPN6	5	PTPN6 [specific granule lumen] (R-HSA-6799641) PTPN6 [extracellular region] (R-HSA-6806315) PTPN6 [tertiary granule lumen] (R-HSA-6800952) PTPN6 [nucleoplasm] (R-HSA-9008911) PTPN6 [cytosol] (R-HSA-197938)	0.524	3
UniProt:Q969K3 RNF34	2	RNF34 [nucleoplasm] (R-HSA-6804442) RNF34 [cytosol] (R-HSA-975998)	0.508	3
UniProt:Q9Y3D6 FIS1	2	FIS1 [peroxisomal membrane] (R-HSA-9033123) FIS1 [cytosol] (R-HSA-9033099)	0.499	2
UniProt:P21580 TNFAIP3	1	TNFAIP3 [cytosol] (R-HSA-688989)	0.499	3
UniProt:Q9UDY8 MALT1	1	MALT1 [cytosol] (R-HSA-202461)	0.499	10

Cite Us!