Reactome | PIN1 [nucleoplasm]

PIN1 [nucleoplasm]

Stable Identifier

R-HSA-936016

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, PIN1_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q13526 PIN1

Gene Names

PIN1

Chain

chain:1-163

Reference Genes

BioGPS Gene:5300 PIN1

COSMIC (genes):PIN1 PIN1

CTD Gene:5300 PIN1

dbSNP Gene:5300 PIN1

ENSEMBL:ENSG00000127445 PIN1

HGNC:8988 PIN1

KEGG:hsa:5300 PIN1

Monarch:5300 PIN1

NCBI Gene:5300 PIN1

OMIM:601052 PIN1

UCSC:Q13526 PIN1

Reference Transcript

RefSeq:NM_006221.3 PIN1

Other Identifiers

11744155_x_at

11751059_x_at

16858026

202927_3p_at

202927_PM_at

202927_at

3820178

3820179

3820180

3820181

3820182

3820183

3820184

3820185

3820186

3820187

3820188

3820189

3820196

3820197

3820198

3820199

3820200

3820201

3820202

3820203

3820204

40421_at

5300

8025506

80754_at

A_23_P67162

A_33_P3210168

GE59199

GO:0000413

GO:0001666

GO:0001932

GO:0001934

GO:0003755

GO:0003774

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005815

GO:0005829

GO:0006355

GO:0007088

GO:0008013

GO:0008092

GO:0010468

GO:0016607

GO:0016853

GO:0016859

GO:0030154

GO:0030182

GO:0030496

GO:0030512

GO:0031434

GO:0031647

GO:0032091

GO:0032092

GO:0032465

GO:0032794

GO:0034330

GO:0035307

GO:0036064

GO:0042177

GO:0043226

GO:0043547

GO:0045944

GO:0048156

GO:0050808

GO:0050815

GO:0050816

GO:0050821

GO:0051219

GO:0060255

GO:0060392

GO:0070373

GO:0080090

GO:0090263

GO:0098772

GO:0098978

GO:0099524

GO:0140096

GO:1900180

GO:1902430

GO:1990757

GO:2000146

HMNXSV003001271

ILMN_1776375

PH_hs_0033354

TC19000165.hg

TC19001974.hg

U49070_at

g5453897_3p_at

g5453897_3p_s_at

g5453897_3p_x_at

p25107

p33690

Participates

as a component of

as an input of

as an output of

PIN1 mediated IRF3 degradation (Homo sapiens)

Other forms of this molecule

PIN1 [cytosol]

Inferred To

PIN1 [nucleoplasm] (Bos taurus)

PIN1 [nucleoplasm] (Canis familiaris)

PIN1 [nucleoplasm] (Gallus gallus)

PIN1 [nucleoplasm] (Sus scrofa)

pinn-1 [nucleoplasm] (Caenorhabditis elegans)

pinA [nucleoplasm] (Dictyostelium discoideum)

dod [nucleoplasm] (Drosophila melanogaster)

Pin1 [nucleoplasm] (Mus musculus)

Pin1 [nucleoplasm] (Rattus norvegicus)

ESS1 [nucleoplasm] (Saccharomyces cerevisiae)

pin1 [nucleoplasm] (Danio rerio)

pin1 [nucleoplasm] (Schizosaccharomyces pombe)

pin1 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_006212.1

Guide to Pharmacology - Targets

3171

OpenTargets

ENSG00000127445

ENSEMBL

ENSP00000247970, ENSP00000466962, ENST00000588695, ENST00000247970

ZINC - Substances

PIN1_HUMAN

ZINC target

Q13526

PRO

Q13526

GlyGen

Q13526

PDB

1PIN, 2M8I, 2F21, 2ZQT, 7BDP, 3NTP, 8C3C, 3TC5, 3KAC, 7NJ6, 2ZQV, 2N1O, 3KAF, 3WH0, 7BGW, 2KBU, 2M9E, 3I6C, 2KCF, 6O34, 7AOG, 6SVC, 2RUD, 2XP5, 5B3Z, 3IKG, 2XP9, 2XPB, 3IKD, 2RUR, 5GPH, 3TDB, 4TYO, 7AZ1, 2ZR5, 6VAJ, 7SUQ, 7OQ9, 7NJA, 7NRL, 4TNS, 3KAG, 7SA5, 5B3Y, 5UY9, 3JYJ, 6SVE, 7BG3, 7BFW, 2XP6, 2RUC, 3OOB, 3KCE, 2Q5A, 3KAI, 2M9I, 7NIF, 4U84, 1NMW, 4GWT, 3TCZ, 2M8J, 7AZ2, 2ZQS, 2ZQU, 3ODK, 3KAD, 1I6C, 7OQA, 1ZCN, 3KAH, 2LB3, 7NJ8, 7EFX, 6DUN, 5BMY, 6O33, 7BGR, 5B3W, 4QIB, 2XP3, 7BDY, 7EKV, 2XP7, 1I8H, 6SVH, 4U85, 5VTJ, 2RUQ, 2M9F, 7NIG, 1NMV, 4U86, 8C2G, 7BDT, 7EFJ, 4GWV, 2ZR4, 2ZR6, 7SUR, 3KAB, 7AXN, 2ITK, 7NRK, 5VTK, 7AYF, 7BGQ, 1I8G, 7BGV, 2XP4, 3IK8, 7F0M, 5B3X, 2XP8, 1F8A, 5VTI, 2M9J, 2XPA

IntEnz

5.2.1.8

HPA

ENSG00000127445-PIN1

Pharos - Targets

Q13526

ZINC - Predictions - Purchasable

PIN1_HUMAN

Interactors (161)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.846	14
UniProt:Q12933 TRAF2	5	TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199)	0.781	7
UniProt:Q99750 MDFI			0.781	7
UniProt:Q15025 TNIP1	1	TNIP1 [cytosol] (R-HSA-5690853)	0.781	7
UniProt:Q9Y3Q8 T22D4			0.781	7
UniProt:Q15742 NAB2	1	NAB2 [nucleoplasm] (R-HSA-9612177)	0.718	6
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.718	6
UniProt:Q96MH2 HEXI2			0.718	6
UniProt:Q6AI12 ANR40			0.718	6
UniProt:O76015 KRT38	1	KRT38 [cytosol] (R-HSA-6809615)	0.718	6
UniProt:Q9UKT9 IKZF3			0.718	8
UniProt:O15409 FOXP2			0.718	6
UniProt:Q96C00 ZBTB9			0.718	6
UniProt:Q8TAP6 CEP76	1	CEP76 [cytosol] (R-HSA-380281)	0.718	6
UniProt:Q9NWS9-2 ZNF446			0.718	6
UniProt:Q52MB2 CC184			0.718	6
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.718	6
UniProt:Q969H4 CNKSR1	1	CNKSR1 [cytosol] (R-HSA-5672629)	0.718	6
UniProt:P60409 KRTAP10-7	1	KRTAP10-7 [cytosol] (R-HSA-6810279)	0.718	6
UniProt:P37198 NUP62	2	NUP62 [nuclear envelope] (R-HSA-157713) NUP62 [cytosol] (R-HSA-9634226)	0.718	6
UniProt:Q9BWW4 SSBP3			0.718	6
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.71	5
UniProt:P85298-4 ARHGAP8			0.672	25
UniProt:P41212 ETV6	14	ETV6(1-384)-p-6Y-FLT3(573-993) fusion [cytosol] (R-HSA-9703308) ETV6(1-154)insGSFILG-p-6Y-FLT3(573-993) fusion [cytosol] (R-HSA-9703302) ETV6(1-336)insGCS-p-6Y-FLT3(573-993) fusion [cytosol] (R-HSA-9703305) ETV6(1-301)-p-6Y-FLT3(574-993) fusion [cytosol] (R-HSA-9703318) ETV6(1-384)-p-3Y-FLT3(659-1620) fusion [cytosol] (R-HSA-9703313) ETV6(1-154)insGSFILG-FLT3(573-993) fusion [cytosol] (R-HSA-9703312) ETV6(1-336)insGCS-FLT3(573-993) fusion [cytosol] (R-HSA-9703320) ETV6(1-384)-FLT3(573-993) fusion [cytosol] (R-HSA-9703307) ETV6(1-301)-FLT3(574-993) fusion [cytosol] (R-HSA-9703315) ETV6(1-384)-FLT3(569-993) fusion [cytosol] (R-HSA-9697944) ETV6(1-384)-PDGFRA(552-1089) fusion [plasma membrane] (R-HSA-9673898) ETV6(1-154)-PDGFRB(527-1106) fusion [plasma membrane] (R-HSA-9673893) p-11Y-ETV6(1-384)-PDGFRA(552-1089) fusion [plasma membrane] (R-HSA-9673905) p-12Y-ETV6(1-154)-PDGFRB(527-1106) fusion [plasma membrane] (R-HSA-9673912)	0.666	4
UniProt:Q93062 RBPMS			0.666	4
UniProt:Q9BWG4 SSBP4			0.666	4
UniProt:P35520 CBS	1	PXLP-K119-CBS [cytosol] (R-HSA-1614563)	0.666	4
UniProt:Q9NYB9 ABI2	2	p-4S-ABI2 [cytosol] (R-HSA-2029003) ABI2 [cytosol] (R-HSA-1671647)	0.666	5
UniProt:Q15233 NONO			0.666	4
UniProt:Q9BT49 THAP7			0.666	5
UniProt:Q8NF64 ZMIZ2			0.666	4
UniProt:Q96AA8 JKIP2			0.666	4
UniProt:Q7Z5J4 RAI1	1	RAI1 [nucleoplasm] (R-HSA-5656531)	0.666	4
UniProt:O00267 SUPT5H	1	p-SUPT5H [nucleoplasm] (R-HSA-3009372)	0.666	4
UniProt:P41279 MAP3K8	3	p-S400,T290-MAP3K8 [cytosol] (R-HSA-5684259) MAP3K8 [cytosol] (R-HSA-389388) p-S400-MAP3K8 [cytosol] (R-HSA-389738)	0.66	8
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.646	4
UniProt:P51617 IRAK1	14	IRAK1 [cytosol] (R-HSA-446639) p-2S,S376,T,T209,T387-IRAK1 [cytosol] (R-HSA-446682) p-2S,S376,T,T209,T387-IRAK1 [plasma membrane] (R-HSA-937011) p-T209,T387-IRAK1 [plasma membrane] (R-HSA-166279) p-T209-IRAK1 [plasma membrane] (R-HSA-937031) IRAK1 [plasma membrane] (R-HSA-937045) p-2S,S376,T,T209,T387-IRAK1 [endosome membrane] (R-HSA-975157) IRAK1 [endosome membrane] (R-HSA-975127) p-T209,T387-IRAK1 [endosome membrane] (R-HSA-975117) p-T209-IRAK1 [endosome membrane] (R-HSA-975189) K63polyUb-hp-IRAK1 [cytosol] (R-HSA-451565) p-S376,T387-IRAK1 [cytosol] (R-HSA-446687) K63polyUb-hp-IRAK1 [endosome membrane] (R-HSA-975112) p-S,T-IRAK1 [cytosol] (R-HSA-3149574)	0.645	10
UniProt:Q63932	3	phospho-p-S,T-MAP2K2 [cytosol] (R-MMU-109848) MAP2K2 [cytosol] (R-MMU-59504) phospho-p-S222,S226-MAP2K2 [cytosol] (R-MMU-169292)	0.628	12
UniProt:Q13342 SP140			0.611	4
IntAct:EBI-10173330 386677			0.601	4
UniProt:Q15131 CDK10			0.591	5
UniProt:Q13950 RUNX2			0.591	7
UniProt:P46531 NOTCH1	20	NOTCH1 L1678P S2 cleavage fragment [extracellular region] (R-HSA-2730745) NOTCH1 I1680N S2 cleavage fragment [extracellular region] (R-HSA-2730744) NOTCH1 I1718T S2 cleavage fragment [extracellular region] (R-HSA-2730757) NOTCH1 A1701P S2 cleavage fragment [plasma membrane] (R-HSA-2730742) NOTCH1 V1676D S2 cleavage fragment [extracellular region] (R-HSA-2730755) NOTCH1 I1680N Transmembrane Fragment [plasma membrane] (R-HSA-2684869) NOTCH1 I1718T Transmembrane Fragment [plasma membrane] (R-HSA-2684881) NOTCH1 I1616T Extracellular Fragment [extracellular region] (R-HSA-2684866) NOTCH1 L1596H Extracellular Fragment [extracellular region] (R-HSA-2684853) NOTCH1 L1678P Transmembrane Fragment [plasma membrane] (R-HSA-1485591) NOTCH1 A1701P Transmembrane Fragment [plasma membrane] (R-HSA-1485585) NOTCH1 I1616N Extracellular Fragment [extracellular region] (R-HSA-2684862) NOTCH1 L1593P Extracellular Fragment [extracellular region] (R-HSA-1485584) NOTCH1 R1598P Extracellular Fragment [extracellular region] (R-HSA-1485592) NOTCH1 V1576E Extracellular Fragment [extracellular region] (R-HSA-2684852) NOTCH1 V1676D Transmembrane Fragment [plasma membrane] (R-HSA-2684874) NOTCH1 F1592S Extracellular Fragment [extracellular region] (R-HSA-2684847) NOTCH1 L1574Q Extracellular Fragment [extracellular region] (R-HSA-2691203) p-NICD1 Q2440* [nucleoplasm] (R-HSA-2902207) p-NICD1 Q2395* [nucleoplasm] (R-HSA-2902205)	0.591	9
UniProt:Q96A49 SYAP1			0.589	2
UniProt:Q9BR01 SULT4A1	1	SULT4A1 [cytosol] (R-HSA-176668)	0.581	4
UniProt:P78563 ADARB1	1	ADARB1 [nucleoplasm] (R-HSA-62915)	0.571	12
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.564	2
UniProt:P31938 Map2k1	5	phospho-p-S,218, S222,T292 MAP2K1 [cytosol] (R-MMU-5674490) phospho-p-T286,T292-MAP2K1 [cytosol] (R-MMU-112374) phospho-p-S218,S222,T286,T292-MAP2K1 [cytosol] (R-MMU-112339) Mek1 [cytosol] (R-MMU-451658) Phospho Mek1 [cytosol] (R-MMU-451693)	0.558	4
UniProt:Q9H165-2 BCL11A			0.556	3
UniProt:Q16254 E2F4	1	E2F4 [nucleoplasm] (R-HSA-68664)	0.556	3
UniProt:Q9BTY2 FUCA2	4	FUCA2 [extracellular region] (R-HSA-6806227) FUCA2 [azurophil granule lumen] (R-HSA-6798772) p-FUCA2 [endoplasmic reticulum lumen] (R-HSA-8957005) FUCA2 [endoplasmic reticulum lumen] (R-HSA-8956727)	0.556	3
UniProt:Q96IF1 AJUBA	3	AJUBA [nucleoplasm] (R-HSA-5687935) p-S-AJUBA [cytosol] (R-HSA-2574841) AJUBA [cytosol] (R-HSA-2564698)	0.556	3
UniProt:Q9H0X6 RN208			0.556	3
UniProt:Q99708-2 RBBP8			0.556	3
UniProt:Q8N5C8 TAB3	3	TAB3 [plasma membrane] (R-HSA-446879) TAB3 [endosome membrane] (R-HSA-450247) TAB3 [cytosol] (R-HSA-450264)	0.556	3
UniProt:Q8NC74 RB8NL			0.556	3
UniProt:Q9BYR5 KRTAP4-2	1	KRTAP4-2 [cytosol] (R-HSA-6809948)	0.556	3
UniProt:Q96MP8-2 KCTD7			0.556	3
UniProt:Q8ND90 PNMA1			0.556	3
UniProt:Q5JR59-3 MTUS2			0.556	3
IntAct:EBI-10171679 386682			0.556	3
UniProt:Q03989 ARI5A			0.556	3
UniProt:Q9NR12 PDLIM7	1	PDLIM7 [cytosol] (R-HSA-8855085)	0.556	3
UniProt:Q6UY14-3 ADAMTSL4			0.556	3
UniProt:Q5TD97 FHL5			0.556	3
UniProt:Q9H0E9-2 BRD8			0.556	3
UniProt:Q13422 IKZF1			0.556	3
UniProt:Q12951-2 FOXI1			0.556	3
UniProt:A6NC98 CC88B			0.556	3
UniProt:Q8NA61-2 CBY2			0.556	3
UniProt:P0C1Z6 TFPT	1	TFPT [nucleoplasm] (R-HSA-5689542)	0.556	3
UniProt:Q14CS0 UBX2B			0.556	3
UniProt:Q9UKD1 GMEB2			0.556	3
UniProt:Q15654 TRIP6			0.556	3
UniProt:O00167-2 EYA2			0.556	3
UniProt:O76011 KRT34	1	KRT34 [cytosol] (R-HSA-6809608)	0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:Q9UPG8 PLAL2			0.556	3
UniProt:Q5JR59 MTUS2			0.556	3
UniProt:O76014 KRT37	1	KRT37 [cytosol] (R-HSA-6809614)	0.556	3
UniProt:O15353 FOXN1			0.556	3
UniProt:Q86V38 Q86V38			0.556	3
UniProt:Q8NF64-3 ZMIZ2			0.556	3
UniProt:Q9H5H4 ZN768			0.556	5
UniProt:O94989 ARHGEF15	1	ARHGEF15 [cytosol] (R-HSA-3550803)	0.556	3
UniProt:Q8NF64-2 ZMIZ2			0.556	3
UniProt:Q9H3D4 TP63	1	TP63 [nucleoplasm] (R-HSA-2997585)	0.556	3
UniProt:A6NEM1 GG6L9			0.556	3
UniProt:B2RXF5 ZBT42			0.556	3
UniProt:Q13422-7 IKZF1			0.556	3
UniProt:Q63HR2 TENS2			0.556	3
UniProt:A1L4H1 SSC5D	1	SSC5D [extracellular region] (R-HSA-8878615)	0.556	3
IntAct:EBI-22384398 CCSB ORF ID			0.556	3
UniProt:Q9NYB9-2 ABI2			0.556	3
IntAct:EBI-10171584 80125			0.556	3
UniProt:Q53EZ4 CEP55			0.556	3
UniProt:Q9UHD9 UBQLN2	1	UBQLN2 [cytosol] (R-HSA-8866007)	0.556	5
UniProt:P26371 KRTAP5-9	1	KRTAP5-9 [cytosol] (R-HSA-6810265)	0.556	3
UniProt:Q96KG9-4 SCYL1			0.556	3
UniProt:Q8TDT2 GP152			0.556	3
IntAct:EBI-22343137 CCSB ORF ID			0.556	3
UniProt:Q8NBZ0 INO80E	1	INO80E [nucleoplasm] (R-HSA-5689552)	0.556	3
UniProt:Q16204 CCDC6			0.556	6
UniProt:Q494R4-2 DRC12			0.556	3
UniProt:Q15233-2 NONO			0.556	3
UniProt:Q96M27 PRRC1			0.556	3
UniProt:P80188 LCN2	2	LCN2 [extracellular region] (R-HSA-5215934) LCN2 [specific granule lumen] (R-HSA-6799614)	0.556	3
UniProt:Q6P9G9 ZN449			0.556	3
UniProt:O43829 ZBT14			0.556	3
UniProt:Q9HC98 NEK6	2	p-S206-NEK6 [cytosol] (R-HSA-2984253) NEK6 [cytosol] (R-HSA-2530596)	0.556	3
IntAct:EBI-16439879 CCSB ORF ID			0.556	3
IntAct:EBI-16436244 CCSB ORF ID			0.556	3
UniProt:P59797 SELV			0.556	3
UniProt:Q8IX15-3 HOMEZ			0.556	3
UniProt:A0A384NQ31 A0A384NQ31			0.556	3
UniProt:Q9HD90 NDF4			0.556	3
UniProt:Q9H3P2 NELFA	1	NELFA [nucleoplasm] (R-HSA-112426)	0.556	3
UniProt:Q3SXR2 CC036			0.556	3
UniProt:Q6ZMS7-2 Q6ZMS72			0.556	3
UniProt:O43281-2 EFS			0.556	3
UniProt:O15209 ZBT22			0.556	3
UniProt:Q8TF50 ZN526			0.556	3
UniProt:Q9NZQ3-3 NCKIPSD			0.556	3
UniProt:Q8N680 ZBTB2			0.556	3
UniProt:P40424 PBX1	1	PBX1 [nucleoplasm] (R-HSA-453045)	0.556	3
UniProt:O75553-5 DAB1			0.556	3
UniProt:P15884 TCF4	1	TCF4 [nucleoplasm] (R-HSA-445672)	0.556	3
UniProt:Q8NFH5 NUP35	2	NUP35 [cytosol] (R-HSA-9634171) NUP35 [nuclear envelope] (R-HSA-157748)	0.556	5
UniProt:P60410 KRTAP10-8	1	KRTAP10-8 [cytosol] (R-HSA-6810301)	0.556	3
UniProt:P60411 KRTAP10-9	1	KRTAP10-9 [cytosol] (R-HSA-6810277)	0.556	3
UniProt:A2BDD9 A2BDD9			0.556	3
UniProt:P60371 KRTAP10-6	1	KRTAP10-6 [cytosol] (R-HSA-6810247)	0.556	3
UniProt:P13349 MYF5	1	MYF5 [nucleoplasm] (R-HSA-445158)	0.556	3
UniProt:P15407 FOSL1	1	FOSL1 [nucleoplasm] (R-HSA-9620405)	0.556	3
UniProt:Q8NA61 CBY2			0.556	3
UniProt:O15156 ZBT7B			0.556	3
UniProt:Q99081-3 TCF12			0.556	3
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.556	3
UniProt:Q9BVG8-5 KIFC3			0.556	3
UniProt:P50221 MEOX1			0.556	3
UniProt:P50222 MEOX2			0.556	3
UniProt:Q9H7P9 PLEKHG2	1	PLEKHG2 [cytosol] (R-HSA-195043)	0.556	3
UniProt:P55198 AF17			0.556	3
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.556	5
UniProt:P01100 FOS	2	FOS [nucleoplasm] (R-HSA-450216) p-T325,T331,S362,S374-FOS [nucleoplasm] (R-HSA-450283)	0.556	3
UniProt:Q4VCS5-2 AMOT	1	AMOT-2 [cytosol] (R-HSA-9761473)	0.556	3
UniProt:Q8N9R8 SCAI	1	SCAI [nucleoplasm] (R-HSA-5666012)	0.556	3
UniProt:P08151 GLI1	9	ub-GLI1 [cytosol] (R-HSA-5635833) ub-pS-GLI1 [ciliary base] (R-HSA-5610514) pS-GLI1 [ciliary base] (R-HSA-5610497) GLI1 [cytosol] (R-HSA-445457) p-GLI1 [ciliary tip] (R-HSA-5635040) 2p-GLI1 [nucleoplasm] (R-HSA-5635057) p-GLI1 [nucleoplasm] (R-HSA-5635042) GLI1 [ciliary base] (R-HSA-5610357) GLI1 [ciliary tip] (R-HSA-5610360)	0.556	3
UniProt:P14373 TRIM27	2	TRIM27 [cytosol] (R-HSA-8851002) TRIM27 [nucleoplasm] (R-HSA-2997690)	0.556	3
UniProt:P26367 PAX6	1	PAX6 [nucleoplasm] (R-HSA-3009044)	0.556	3
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.556	3
UniProt:O75553 DAB1	2	DAB1 [cytosol] (R-HSA-8855236) p-Y198,220,232-DAB1 [cytosol] (R-HSA-8855227)	0.556	3
UniProt:Q92570 NR4A3	1	NR4A3 [nucleoplasm] (R-HSA-8938004)	0.556	3
UniProt:P68400 CSNK2A1	2	CSNK2A1 [cytosol] (R-HSA-201713) CSNK2A1 [nucleoplasm] (R-HSA-6805057)	0.544	2
UniProt:Q3UVX5	1	GRM5 [plasma membrane] (R-MMU-420553)	0.544	2
UniProt:Q8WVK2 SNRNP27	1	SNRNP27 [nucleoplasm] (R-HSA-6806778)	0.527	2
UniProt:P04798 CYP1A1	1	CYP1A1 [endoplasmic reticulum membrane] (R-HSA-52623)	0.527	2
UniProt:P48426 PIP4K2A	2	PIP4K2A [cytosol] (R-HSA-1604641) PIP4K2A [nucleoplasm] (R-HSA-6811484)	0.527	2
UniProt:P31424-2 GRM5			0.524	3
UniProt:Q02750 MAP2K1	20	MAP2K1(9-393) [cytosol] (R-HSA-5211353) MAP2K1(2-8) [cytosol] (R-HSA-5211342) MAP2K1 F53S [cytosol] (R-HSA-9652034) MAP2K1 D67N [cytosol] (R-HSA-9652016) p-S218,S222-MAP2K1 [cytosol] (R-HSA-109837) MAP2K1 [cytosol] (R-HSA-59502) p-S218,S222,T286,T292-MAP2K1 [cytosol] (R-HSA-112339) p-T286,T292-MAP2K1 [cytosol] (R-HSA-112374) p-S,218, S222,T292 MAP2K1 [cytosol] (R-HSA-5674490) MAP2K1 F53C [cytosol] (R-HSA-9652028) MAP2K1 P124Q [cytosol] (R-HSA-9652058) MAP2K1 L42_K57del [cytosol] (R-HSA-9652026) MAP2K1 F53Y [cytosol] (R-HSA-9652041) MAP2K1 P124L [cytosol] (R-HSA-9652056) MAP2K1 G128D [cytosol] (R-HSA-9652043) MAP2K1 D67Y [cytosol] (R-HSA-9652019) MAP2K1 F53V [cytosol] (R-HSA-9652038) MAP2K1 K57T [cytosol] (R-HSA-9652052) MAP2K1 K57N [cytosol] (R-HSA-9652050) MAP2K1 F53L [cytosol] (R-HSA-9652031)	0.508	5
UniProt:Q99728-1 BARD1			0.499	4

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