Reactome | RNF135 [cytosol]

RNF135 [cytosol]

Stable Identifier

R-HSA-936042

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

RING finger protein 135, RN135_HUMAN, REUL, Riplet

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        SARS-CoV-2-host interactions (Homo sapiens)
        
        SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
        
        DDX58 is K63 polyubiquitinated (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        TBK1, IKBKE are autophosphorylated at Ser172 (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2x(TBK1/IKBKE) [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2xIKK related kinases TBK1/IKK epsilon [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)

Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
    - DDX58 is K63 polyubiquitinated (Homo sapiens)
      - 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
      - RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
    - NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 (Homo sapiens)
      - Dimerzation of procaspase-8, procaspase-10 (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:2xCASP8(1-479), CASP10(1-521) [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:CASP8(1-479), CASP10(1-521) [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
      - MAVS interacts with RIPK1 and FADD (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
      - Processing of caspases (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:2xCASP8(1-216), CASP10(1-219) [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:CASP8(1-216), CASP10(1-219) [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:2xCASP8(1-479), CASP10(1-521) [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
      - Recruitment of IKK complex (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:TRAF2/TRAF6:IPS-1:RIP-1/FADD:Casp-8/10 prodomain:IKK complex [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:RIG-I/MDA5:TRAF2/TRAF6:IPS-1:RIP-1/FADD:Casp-8/10 prodomain [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        viral dsRNA:RIG-I/MDA5:TRAF2/TRAF6:IPS-1:RIP-1/FADD:Casp-8/10 prodomain [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
      - Recruitment of caspase-8 and -10 to FADD complex (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:CASP8(1-479), CASP10(1-521) [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
    - Negative regulators of DDX58/IFIH1 signaling (Homo sapiens)
      - Inhibition of DDX58/IFIH1 signaling by ATG5:ATG12:MAVS (Homo sapiens)
        
        dsRNA:DDX58, IFIH1:MAVS:ATG5:ATG12 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
      - Interaction of PCBP2 with MAVS (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:PCBP2 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
      - NLRC5 interacts with DDX58/IFIH1 (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP:NLRC5 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
      - Negative regulation of DDX58/IFIH1 signaling by RNF216 (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
      - OTUD5 deubiquitinates TRAF3 (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
      - Recruitment of ITCH and K48 ubiquitination of MAVS (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:PCBP2 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:PCBP2:ITCH [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP:K48polyUb-MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
    - TRAF3-dependent IRF activation pathway (Homo sapiens)
      - Phosphorylation and release of IRF3/IRF7 (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2x(TBK1/IKBKE) [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2xTBK1,IKBKE:IRF3,IRF7 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2x(TBK1/IKBKE) [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
      - Recruitment of IRF3,IRF7 (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2x(TBK1/IKBKE) [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2xTBK1,IKBKE:IRF3,IRF7 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2x(TBK1/IKBKE) [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
      - Recruitment of TRAF3 to MAVS (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
      - TBK1 or IKBKE forms homodimers (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2xIKK related kinases TBK1/IKK epsilon [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
      - TBK1, IKBKE are autophosphorylated at Ser172 (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2x(TBK1/IKBKE) [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2xIKK related kinases TBK1/IKK epsilon [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
      - TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
    - TRAF6 mediated IRF7 activation (Homo sapiens)
      - Phosphorylation and release of IRF7 (Homo sapiens)
        
        dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK:2xpS172-TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:DDX58/dsRNA:IFIH1:MAVS:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK:TBK1/IKBKE:IRF7 [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK:2xpS172-TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:DDX58/dsRNA:IFIH1:MAVS:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
      - Phosphorylation of TBK1/IKBKE (Homo sapiens)
        
        dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK:2xTBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:DDX58/dsRNA:IFIH1:MAVS:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK:2xpS172-TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:DDX58/dsRNA:IFIH1:MAVS:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
      - Recruitment of IRF7 to TRAF6 (Homo sapiens)
        
        dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK:2xpS172-TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:DDX58/dsRNA:IFIH1:MAVS:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK:TBK1/IKBKE:IRF7 [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK:2xpS172-TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:DDX58/dsRNA:IFIH1:MAVS:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
      - Recruitment of TANK to TRAF6 (Homo sapiens)
        
        dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:DDX58/dsRNA:IFIH1:MAVS:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        dsRNA:DDX58/dsRNA:IFIH1:MAVS:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
      - Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 (Homo sapiens)
        
        dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:DDX58/dsRNA:IFIH1:MAVS:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK:TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:DDX58/dsRNA:IFIH1:MAVS:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
      - Recruitment of TRAF6/TRAF2 to MAVS (Homo sapiens)
        
        dsRNA:DDX58/dsRNA:IFIH1:MAVS:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
      - TBK1, IKBKE form homodimers (Homo sapiens)
        
        dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK:2xTBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:DDX58/dsRNA:IFIH1:MAVS:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK:TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:DDX58/dsRNA:IFIH1:MAVS:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
    - TRAF6 mediated NF-kB activation (Homo sapiens)
      - Activation of IKK by MEKK1 (Homo sapiens)
        
        dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:MEKK1 [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:DDX58/dsRNA:IFIH1:MAVS:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
      - Interaction of MEKK1 with TRAF6 (Homo sapiens)
        
        dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:MEKK1 [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:DDX58/dsRNA:IFIH1:MAVS:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        dsRNA:DDX58/dsRNA:IFIH1:MAVS:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
    - viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS (Homo sapiens)
      - viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
      - viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP:NLRC5 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
      - viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - Ovarian tumor domain proteases (Homo sapiens)
      - OTUD5 deubiquitinates TRAF3 (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8IUD6 RNF135

Gene Names

RNF135, L13

Chain

chain:1-432

Reference Genes

BioGPS Gene:84282 RNF135

COSMIC (genes):RNF135 RNF135

CTD Gene:84282 RNF135

dbSNP Gene:84282 RNF135

ENSEMBL:ENSG00000181481 RNF135

HGNC:21158 RNF135

KEGG:hsa:84282 RNF135

Monarch:84282 RNF135

NCBI Gene:84282 RNF135

OMIM:611358 RNF135

UCSC:Q8IUD6 RNF135

Reference Transcript

Other Identifiers

11735429_x_at

11736287_a_at

16832896

223591_PM_at

223591_at

223592_PM_s_at

223592_s_at

2344801

3716994

3716995

3716996

3716997

3716998

3717001

3717002

3717003

3717004

3717005

3717006

3717007

3717008

3717009

3717010

44536_at

73743_at

8006229

84282

86371_at

A_14_P120660

A_23_P252283

A_24_P39759

GE83378

GO:0000209

GO:0002376

GO:0003824

GO:0004842

GO:0005515

GO:0005737

GO:0005829

GO:0010494

GO:0010994

GO:0016567

GO:0016740

GO:0032446

GO:0032728

GO:0039529

GO:0039552

GO:0042802

GO:0043021

GO:0043226

GO:0045087

GO:0045088

GO:0046872

GO:0051260

GO:0061630

GO:0065003

GO:0070534

GO:0098542

GO:0140096

GO:0140374

GO:1990904

HMNXSV003006661

ILMN_1700660

ILMN_1738883

ILMN_2407529

PH_hs_0028839

TC17000358.hg

g13477234_3p_at

g13477234_3p_s_at

Participates

as a member of

RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)

Cross References

ENSEMBL

ENST00000708426, ENST00000328381, ENST00000324689, ENST00000535306, ENSP00000440470, ENSP00000517221, ENSP00000517220, ENSP00000517222, ENSG00000291712, ENSG00000181481, ENST00000708427, ENST00000708425, ENSP00000328340, ENSP00000323693

OpenTargets

ENSG00000181481

GeneCards

RNF135

HPA

ENSG00000181481-RNF135

PRO

Q8IUD6

Pharos - Targets

Q8IUD6

GlyGen

Q8IUD6

Orphanet

RNF135

PDB

8G7V, 8G7T, 8G7U, 7JL1, 7JL3

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.718	6
UniProt:P40222 TXLNA	1	TXLNA [cytosol] (R-HSA-449124)	0.527	2
UniProt:Q13426 XRCC4	2	XRCC4 [nucleoplasm] (R-HSA-75911) monoSUMO1-K210-XRCC4 [nucleoplasm] (R-HSA-4568892)	0.527	2

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