OTUD5 deubiquitinates TRAF3

Stable Identifier
R-HSA-936381
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Influenza A virus, Human respiratory syncytial virus A, Rotavirus, Hepatitis C Virus, Measles virus
Compartment
mitochondrial outer membrane, cytosol
Synonyms
Negative regulation of RIG-I/MDA5 signaling by DUBA
ReviewStatus
5/5
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OTUD5 deubiquitinates TRAF3
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OTUD5 (Deubiquitinating enzyme A (DUBA)) is a negative regulator of type I interferon (IFN-) production. TRAF3, an E3 ubiquitin ligase that preferentially assembles lysine-63-linked polyubiquitin chains, is one of the targets of OTUD5. Expression of DUBA increases the cleavage of K63-linked ubiquitin chains from TRAF3, resulting in its dissociation from the downstream signaling complex that contains TANK-binding kinase 1 (TBK1) (Kayagaki et al. 2007), which leads to blockade of IRF3 and IRF7 phosphorylation.

Literature References
PubMed ID Title Journal Year
17991829 DUBA: a deubiquitinase that regulates type I interferon production

Dixit, VM, Zhang, Z, Eby, M, Kayagaki, N, Quan, C, Arnott, D, Chaudhari, R, O'Rourke, KM, Cheng, G, Bazan, JF, Chan, S, Pietras, E, Phung, Q

Science 2007
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Catalyst Activity

Lys63-specific deubiquitinase activity of OTUD5 [cytosol]

Physical Entity
OTUD5 [cytosol] (Homo sapiens)
Activity
Lys63-specific deubiquitinase activity (GO:0061578)
Authored
Garapati, P V  (2010-08-02)
Reviewed
Akira, S  (2010-10-30)
Kawai, T  (2010-10-30)
Created
Garapati, P V  (2010-08-23)
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