OTUD5 (Deubiquitinating enzyme A (DUBA)) is a negative regulator of type I interferon (IFN-) production. TRAF3, an E3 ubiquitin ligase that preferentially assembles lysine-63-linked polyubiquitin chains, is one of the targets of OTUD5. Expression of DUBA increases the cleavage of K63-linked ubiquitin chains from TRAF3, resulting in its dissociation from the downstream signaling complex that contains TANK-binding kinase 1 (TBK1) (Kayagaki et al. 2007), which leads to blockade of IRF3 and IRF7 phosphorylation.
Dixit, VM, Zhang, Z, Eby, M, Kayagaki, N, Quan, C, Arnott, D, Chaudhari, R, O'Rourke, KM, Cheng, G, Bazan, JF, Chan, S, Pietras, E, Phung, Q
Lys63-specific deubiquitinase activity of OTUD5 [cytosol]
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