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UBA7 [cytosol]
Stable Identifier
R-HSA-936550
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
UBE1L, Ubiquitin-like modifier-activating enzyme 7, UBA7_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
E1 mediated ubiquitin activation (Homo sapiens)
E1 bound ubiquitin [cytosol] (Homo sapiens)
Ubiquitin activating E1 enzymes [cytosol] (Homo sapiens)
UBA7 [cytosol] (Homo sapiens)
Ubiquitin activating E1 enzymes [cytosol] (Homo sapiens)
UBA7 [cytosol] (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
Ubiquitin:E2 conjugating enzymes [cytosol] (Homo sapiens)
E2 Ubiquitin-conjugating enzyme [cytosol] (Homo sapiens)
UBA7 [cytosol] (Homo sapiens)
Ubiquitin:E2 conjugating enzymes [cytosol] (Homo sapiens)
E2 Ubiquitin-conjugating enzyme [cytosol] (Homo sapiens)
UBA7 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E2 Ubiquitin-conjugating enzyme [cytosol] (Homo sapiens)
UBA7 [cytosol] (Homo sapiens)
Ubiquitin:E2 conjugating enzymes [cytosol] (Homo sapiens)
E2 Ubiquitin-conjugating enzyme [cytosol] (Homo sapiens)
UBA7 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
Ubiquitin:E2 conjugating enzymes [cytosol] (Homo sapiens)
E2 Ubiquitin-conjugating enzyme [cytosol] (Homo sapiens)
UBA7 [cytosol] (Homo sapiens)
E2 Ubiquitin-conjugating enzyme [cytosol] (Homo sapiens)
UBA7 [cytosol] (Homo sapiens)
Transfer of ubiquitin from E1 to E2 (Homo sapiens)
E1 bound ubiquitin [cytosol] (Homo sapiens)
Ubiquitin activating E1 enzymes [cytosol] (Homo sapiens)
UBA7 [cytosol] (Homo sapiens)
E2 Ubiquitin-conjugating enzyme [cytosol] (Homo sapiens)
UBA7 [cytosol] (Homo sapiens)
Ubiquitin activating E1 enzymes [cytosol] (Homo sapiens)
UBA7 [cytosol] (Homo sapiens)
Ubiquitin:E2 conjugating enzymes [cytosol] (Homo sapiens)
E2 Ubiquitin-conjugating enzyme [cytosol] (Homo sapiens)
UBA7 [cytosol] (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Antiviral mechanism by IFN-stimulated genes (Homo sapiens)
ISG15 antiviral mechanism (Homo sapiens)
Activation of ISG15 by UBA7 E1 ligase (Homo sapiens)
ISG15:UBA7 [cytosol] (Homo sapiens)
UBA7 [cytosol] (Homo sapiens)
UBA7 [cytosol] (Homo sapiens)
Transfer of ISG15 from E1 to E2 (UBCH8) (Homo sapiens)
ISG15:UBA7 [cytosol] (Homo sapiens)
UBA7 [cytosol] (Homo sapiens)
UBA7 [cytosol] (Homo sapiens)
Modulation of host responses by IFN-stimulated genes (Homo sapiens)
ISGylation of DDX58 (RIG-I) (Homo sapiens)
ISG15:UBA7 [cytosol] (Homo sapiens)
UBA7 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
Negative regulators of DDX58/IFIH1 signaling (Homo sapiens)
ISGylation of DDX58 (Homo sapiens)
ISG15:DDX58 conjugate [cytosol] (Homo sapiens)
ISG15:UBEIL/UbcH8:CEB1 [cytosol] (Homo sapiens)
E2 enzymes UbcH8/UBE1L [cytosol] (Homo sapiens)
UBA7 [cytosol] (Homo sapiens)
ISG15:UBEIL/UbcH8:CEB1 [cytosol] (Homo sapiens)
E2 enzymes UbcH8/UBE1L [cytosol] (Homo sapiens)
UBA7 [cytosol] (Homo sapiens)
viral dsRNA binds DDX58 (Homo sapiens)
ISG15:DDX58 conjugate [cytosol] (Homo sapiens)
ISG15:UBEIL/UbcH8:CEB1 [cytosol] (Homo sapiens)
E2 enzymes UbcH8/UBE1L [cytosol] (Homo sapiens)
UBA7 [cytosol] (Homo sapiens)
ISG15:UBEIL/UbcH8:CEB1 [cytosol] (Homo sapiens)
E2 enzymes UbcH8/UBE1L [cytosol] (Homo sapiens)
UBA7 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P41226 UBA7
Gene Names
UBA7, UBE1L, UBE2
Chain
chain:1-1012
Reference Genes
BioGPS Gene:7318 UBA7
COSMIC (genes):UBA7 UBA7
CTD Gene:7318 UBA7
dbSNP Gene:7318 UBA7
ENSEMBL:ENSG00000182179 UBA7
HGNC:12471 UBA7
KEGG:hsa:7318 UBA7
Monarch:7318 UBA7
NCBI Gene:7318 UBA7
OMIM:191325 UBA7
UCSC:P41226 UBA7
Reference Transcript
RefSeq:NM_003335.2 UBA7
Other Identifiers
11718608_at
1294_PM_at
1294_at
16954217
203281_PM_s_at
203281_s_at
2674763
2674764
2674766
2674767
2674768
2674769
2674770
2674771
2674772
2674773
2674774
2674775
2674776
2674777
2674778
2674779
2674780
2674781
2674782
2674783
2674784
2674785
2674786
2674787
2674788
2674789
2674790
2674791
2674792
2674793
2674794
2674795
2674796
2674797
2674798
2674799
2674801
2674802
2674804
2674805
2674806
2674807
7318
8087485
A_23_P21207
GE57635
GO:0002376
GO:0003824
GO:0004842
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006974
GO:0008641
GO:0016567
GO:0016740
GO:0016874
GO:0019782
GO:0019941
GO:0032020
GO:0032446
GO:0036211
GO:0043226
GO:0045087
GO:0098542
GO:0140096
GO:0140657
HMNXSV003027715
HMNXSV003045232
ILMN_1794612
L13852_at
PH_hs_0028782
TC03001418.hg
g4507766_3p_s_at
Participates
as a member of
E2 enzymes UbcH8/UBE1L [cytosol] (Homo sapiens)
as an input of
Activation of ISG15 by UBA7 E1 ligase (Homo sapiens)
as an output of
Transfer of ISG15 from E1 to E2 (UBCH8) (Homo sapiens)
as a component of
ISG15:UBA7 [cytosol] (Homo sapiens)
as a candidate of
Ubiquitin activating E1 enzymes [cytosol] (Homo sapiens)
E2 Ubiquitin-conjugating enzyme [cytosol] (Homo sapiens)
Other forms of this molecule
UBA7 [nucleoplasm]
Inferred To
uba-1 [cytosol]
(Caenorhabditis elegans)
uba1 [cytosol]
(Danio rerio)
uba1 [cytosol]
(Xenopus tropicalis)
Uba7 [cytosol]
(Mus musculus)
Uba7 [cytosol]
(Rattus norvegicus)
Uba1 [cytosol]
(Drosophila melanogaster)
UBA7 [cytosol]
(Bos taurus)
UBA7 [cytosol]
(Canis familiaris)
UBA7 [cytosol]
(Dictyostelium discoideum)
UBA7 [cytosol]
(Gallus gallus)
UBA7 [cytosol]
(Plasmodium falciparum)
UBA7 [cytosol]
(Saccharomyces cerevisiae)
UBA7 [cytosol]
(Schizosaccharomyces pombe)
UBA7 [cytosol]
(Sus scrofa)
Homologues of UBA7 [cytosol]
(Danio rerio)
Homologues of UBA7 [cytosol]
(Plasmodium falciparum)
uba7 [cytosol]
(Danio rerio)
Cross References
RefSeq
NP_003326.2
ENSEMBL
ENSP00000333266
,
ENST00000333486
OpenTargets
ENSG00000182179
HPA
ENSG00000182179-UBA7
ZINC - Substances
UBA7_HUMAN
ZINC target
P41226
PRO
P41226
Pharos - Targets
P41226
ZINC - Predictions - Purchasable
UBA7_HUMAN
HMDB Protein
HMDBP09311
PDB
8SE9
,
8WWX
,
8SEB
,
8OIF
,
8SEA
,
8SV8
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05161 ISG15
4
ISG15 [cytosol]
(R-HSA-936552)
K168-PCNA-G157-ISG15 [nucleoplasm]
(R-HSA-5653744)
K164-PCNA-G157-ISG15 [nucleoplasm]
(R-HSA-5653745)
ISG15 [nucleoplasm]
(R-HSA-5653665)
0.885
12
UniProt:Q13148 TADBP
0.556
3
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