Reactome | ISG15 [cytosol]

ISG15 [cytosol]

Stable Identifier

R-HSA-936552

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Interferon-induced 17 kDa protein component recommendedName: Ubiquitin cross-reactive protein, UCRP_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:O75369 FLNB

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External Reference Information

External Reference

UniProt:P05161 ISG15

Gene Names

ISG15, G1P2, UCRP

Chain

initiator methionine:, chain:2-157, propeptide:158-165

Reference Genes

BioGPS Gene:9636 ISG15

COSMIC (genes):ISG15 ISG15

CTD Gene:9636 ISG15

dbSNP Gene:9636 ISG15

ENSEMBL:ENSG00000187608 ISG15

HGNC:4053 ISG15

KEGG:hsa:9636 ISG15

Monarch:9636 ISG15

NCBI Gene:9636 ISG15

OMIM:147571 ISG15

UCSC:P05161 ISG15

Reference Transcript

RefSeq:NM_005101.3 ISG15

Other Identifiers

1107_s_at

11716895_s_at

16657594

205483_PM_s_at

205483_s_at

38432_at

4053537

4053538

4053541

4053544

4053545

4053546

4053547

4053548

4053549

7896817

9636

A_23_P819

GE62795

GO:0002376

GO:0005178

GO:0005515

GO:0005576

GO:0005654

GO:0005737

GO:0005829

GO:0007229

GO:0009615

GO:0009617

GO:0019941

GO:0030501

GO:0031386

GO:0031397

GO:0031625

GO:0032020

GO:0032461

GO:0032649

GO:0032728

GO:0032729

GO:0032733

GO:0034340

GO:0042742

GO:0045071

GO:0045087

GO:0045648

GO:0051607

GO:0060339

GO:0070585

GO:0098542

HMNXSV003047646

ILMN_2054019

M13755_at

PH_hs_0028539

TC01000023.hg

g4826773_3p_a_at

Participates

as a component of

as an input of

as an output of

This entity regulates

Negatively

Monoubiquitination of N-myristoyl GAG (P12493) protein (Homo sapiens)

Other forms of this molecule

K168-PCNA-G157-ISG15 [nucleoplasm]

K164-PCNA-G157-ISG15 [nucleoplasm]

ISG15 [nucleoplasm]

Inferred To

ubqJ [cytosol] (Dictyostelium discoideum)

Ghost homologue of ISG15 [cytosol] (Danio rerio)

Ghost homologue of ISG15 [cytosol] (Gallus gallus)

Ghost homologue of ISG15 [cytosol] (Xenopus tropicalis)

ubqN [cytosol] (Dictyostelium discoideum)

Isg15 [cytosol] (Mus musculus)

Isg15 [cytosol] (Rattus norvegicus)

ISG15 [cytosol] (Bos taurus)

ISG15 [cytosol] (Caenorhabditis elegans)

ISG15 [cytosol] (Canis familiaris)

ISG15 [cytosol] (Plasmodium falciparum)

ISG15 [cytosol] (Sus scrofa)

ubqI [cytosol] (Dictyostelium discoideum)

ubq-1 [cytosol] (Caenorhabditis elegans)

ubqH [cytosol] (Dictyostelium discoideum)

ubqG [cytosol] (Dictyostelium discoideum)

ubqA [cytosol] (Dictyostelium discoideum)

Homologues of ISG15 [cytosol] (Caenorhabditis elegans)

Homologues of ISG15 [cytosol] (Dictyostelium discoideum)

Ubi-p63E [cytosol] (Drosophila melanogaster)

ubqF [cytosol] (Dictyostelium discoideum)

Cross References

RefSeq

NP_005092.1

OpenTargets

ENSG00000187608

ENSEMBL

ENST00000649529, ENSP00000496832

HPA

ENSG00000187608-ISG15

PRO

P05161

Pharos - Targets

P05161

GlyGen

P05161

Orphanet

ISG15

PDB

8SEA, 3PHX, 3PSE, 8SE9, 5W8U, 5W8T, 8SV8, 3SDL, 2HJ8, 1Z2M, 5TL6, 6FFA, 8SEB, 3R66, 6BI8, 8OIF, 6XA9, 3RT3, 7S6P, 7RBS

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTD1-PRO_0000449621 REP			0.907	13
UniProt:P41226 UBA7	2	UBA7 [nucleoplasm] (R-HSA-5653762) UBA7 [cytosol] (R-HSA-936550)	0.885	12
UniProt:Q9UMW8 USP18	1	USP18 [cytosol] (R-HSA-912325)	0.873	9
UniProt:Q6TQR6 L			0.743	5
UniProt:P0C6U8-PRO_0000338257			0.719	5
UniProt:K9N7C7-PRO_0000422441 REP			0.655	4
UniProt:P03502 NS1			0.65	4
UniProt:Q9BYX4 IFIH1	3	IFIH1 [cytosol] (R-HSA-913536) K48polyUb-IFIH1 [cytosol] (R-HSA-3080557) PolyUb-IFIH1 [cytosol] (R-HSA-6782812)	0.623	7
UniProt:K0BWD0 K0BWD0			0.618	4
UniProt:P03495 NS1			0.602	4
UniProt:O75369 FLNB	1	FLNB [cytosol] (R-HSA-354163)	0.591	4
UniProt:P05000 IFNW1			0.589	2
UniProt:O75688 PPM1B	3	PPM1B(2-282)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9713479) PPM1B(2-282)-ALK(1058-1620) fusion [cytosol] (R-HSA-9713477) PPM1B [cytosol] (R-HSA-1169375)	0.558	2
UniProt:O60260-5 PRKN			0.556	3
UniProt:P0C6X7-PRO_0000037311 REP			0.544	2
UniProt:P32881 IFNA8	1	IFNA8 [extracellular region] (R-HSA-877336)	0.527	2
UniProt:P01566 IFNA10	1	IFNA10 [extracellular region] (R-HSA-877339)	0.527	2
UniProt:P01563 IFNA2	1	IFNA2 [extracellular region] (R-HSA-877349)	0.527	2
UniProt:P01562 IFNA1	1	IFNA1 [extracellular region] (R-HSA-877340)	0.527	2
UniProt:P01570 IFNA14	1	IFNA14 [extracellular region] (R-HSA-877345)	0.527	2
UniProt:P05014 IFNA4	1	IFNA4 [extracellular region] (R-HSA-877342)	0.527	2
UniProt:P01569 IFNA5	1	IFNA5 [extracellular region] (R-HSA-877338)	0.527	2
UniProt:P01568 IFNA21	1	IFNA21 [extracellular region] (R-HSA-877343)	0.527	2

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